Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hyo-Shin Kwak"'
Autor:
Ki Dong Koo, Sang Won Seo, Jae-Ung Choi, Bettina Platt, Dongchul Lim, Deog-Young Choi, Hyo-Shin Kwak, Heuisul Park, Kyeongsik Min
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2900-2904
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.15 μ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf61e1fe152d19a37acc6b6aeac64aac
https://doi.org/10.1016/j.bmcl.2008.03.081
https://doi.org/10.1016/j.bmcl.2008.03.081
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1905-1908
Homolasonolide A and 10-desmethyllasonolide A are biologically less active than lasonolide A. The ethyl ester analogue of lasonolide A exhibited higher activity than the parent compound in some biological test.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339b275781d72a87ae9450f1ccc36c62
https://doi.org/10.1016/j.bmcl.2004.01.088
https://doi.org/10.1016/j.bmcl.2004.01.088
Autor:
Jung Min Joo, Eun Lee, ShinWu Jeong, Ji Hyun Park, Chang Yong Hong, Hyo Shin Kwak, Cheolkyu Jung, Jin Hyun Park, Ho Young Song, Kiwan Jeon, Jung Won Kang, Dae-Shik Kim
Publikováno v:
The Journal of Organic Chemistry. 68:8080-8087
The proposed structure of lasonolide A was synthesized employing radical cyclization reactions of beta-alkoxyacrylates for preparation of the tetrahydropyranyl units A and B, but the spectroscopic data did not match those of the natural product. Both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c247a26dcfb3ca253e93851b77cb3b6b
https://doi.org/10.1021/jo034930n
https://doi.org/10.1021/jo034930n
Autor:
Sun Young Koo, Heui Sul Park, Joonghoon Park, Hyo-Shin Kwak, Hyoung Jin Kim, Dong Wook Kim, Ji-Hoon Park, Hyeon Joo Yim, Eok Park, Myoung-Sub Song, Dong Ook Seo, Soon Ha Kim, Bong-Hyun Ahn
Publikováno v:
Toxicology and applied pharmacology. 263(1)
Oxidative stress is one of the causes of cardiomyopathy. In the present study, NecroXs, novel class of mitochondrial ROS/RNS scavengers, were evaluated for cardioprotection in in vitro and in vivo model, and the putative mechanism of the cardioprotec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d09c50cf3d8fdf1f1d0ee502bab7e9
https://pubmed.ncbi.nlm.nih.gov/22659508
https://pubmed.ncbi.nlm.nih.gov/22659508
Autor:
Young Leem Oh, Heui Sul Park, Chul Woong Chung, Hyoung Jin Kim, Soon Ha Kim, Sun Young Koo, Dong Ook Seo, Oeuk Park, Hyo-Shin Kwak, Doo Hoe Park, Jong Heon Won, Bong-Hyun Ahn, Hyeon Joo Yim
Publikováno v:
Archives of pharmacal research. 33(11)
Mitochondrial reactive oxygen species and reactive nitrogen species are proven to be major sources of oxidative stress in the cell; they play a prominent role in a wide range of human disorders resulting from nonapoptotic cell death. The aim of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3333edb49f63a0d7f36d359f156067
https://pubmed.ncbi.nlm.nih.gov/21116785
https://pubmed.ncbi.nlm.nih.gov/21116785
Publikováno v:
ChemInform. 35
Chiral secondary alcohols may be prepared from primary alcohols via asymmetric C-H insertion reactions of alpha'-alkoxy-alpha-diazoketones catalyzed by rhodium(II)(2R,3R)-3-phenylcholestane-2-carboxylate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a218519da3d5352243ebeac8aa725568
https://doi.org/10.1002/chin.200433085
https://doi.org/10.1002/chin.200433085
Autor:
Ho Young Song, Jung Min Joo, Jung Won Kang, Dae-Shik Kim, Cheol-Kyu Jung, Hyo Shin Kwak, John E., Jin Hyun Park, John E., Eun Lee, Chang Yong Hong, John E., ShinWu Jeong, John E., Kiwan Jeon, John E., Ji Hyun Park, John E.
Publikováno v:
Journal of Organic Chemistry; 10/17/2003, Vol. 68 Issue 21, p8080-8087, 8p, 27 Diagrams, 1 Chart
Publikováno v:
Chemical Communications; Mar2004, Vol. 2004 Issue 7, p816-817, 2p