Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Hynek, Wichterle"'
Autor:
Tulsi Patel, Jennifer Hammelman, Siaresh Aziz, Sumin Jang, Michael Closser, Theodore L. Michaels, Jacob A. Blum, David K. Gifford, Hynek Wichterle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Patel et al. show that gene expression and regulation in motor neurons is dynamic until juvenile age. A core subprogram (~40% of genes) is faithfully recapitulated in cultured motor neurons, with neuronal activity playing only a modulatory role.
Externí odkaz:
https://doaj.org/article/8c6a3121fd1145a590671bdfc9c21b17
Publikováno v:
Nature Methods. 19:812-822
Transcription factor over-expression is a proven method for reprogramming cells to a desired cell type for regenerative medicine and therapeutic discovery. However, a general method for the identification of reprogramming factors to create an arbitra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89819addd442174feb958a2c567bdfa
https://doi.org/10.1038/s41592-022-01522-2
https://doi.org/10.1038/s41592-022-01522-2
Autor:
Disi An, Ryosuke Fujiki, Dylan E Iannitelli, John W Smerdon, Shuvadeep Maity, Matthew F Rose, Alon Gelber, Elizabeth K Wanaselja, Ilona Yagudayeva, Joun Y Lee, Christine Vogel, Hynek Wichterle, Elizabeth C Engle, Esteban Orlando Mazzoni
Publikováno v:
eLife, Vol 8 (2019)
In amyotrophic lateral sclerosis (ALS) spinal motor neurons (SpMN) progressively degenerate while a subset of cranial motor neurons (CrMN) are spared until late stages of the disease. Using a rapid and efficient protocol to differentiate mouse embryo
Externí odkaz:
https://doaj.org/article/0f4bd1185c1e462d992daccca11bd0d2
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 907-916 (2016)
The motor neuron progenitor domain in the ventral spinal cord gives rise to multiple subtypes of motor neurons and glial cells. Here, we examine whether progenitors found in this domain are multipotent and which signals contribute to their cell-type-
Externí odkaz:
https://doaj.org/article/26367d2994024c198cba90098e181501
Autor:
Hai Li, Takaaki Kuwajima, Derek Oakley, Elena Nikulina, Jianwei Hou, Wan Seok Yang, Emily Rhodes Lowry, Nuno Jorge Lamas, Mackenzie Weygandt Amoroso, Gist F. Croft, Raghavendra Hosur, Hynek Wichterle, Said Sebti, Marie T. Filbin, Brent Stockwell, Christopher E. Henderson
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 545-558 (2016)
Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear. We screened 50,400 small molecules for their ability to prom
Externí odkaz:
https://doaj.org/article/95e57b63f0cf462196f27ea438540f9d
Autor:
Han Wee Ong, Yi Liang, William Richardson, Emily R. Lowry, Carrow I. Wells, Xiangrong Chen, Margaux Silvestre, Kelvin Dempster, Josie A. Silvaroli, Jeffery L. Smith, Hynek Wichterle, Navjot S. Pabla, Sila K. Ultanir, Alex N. Bullock, David H. Drewry, Alison D. Axtman
Publikováno v:
bioRxiv
Despite mediating several essential processes in the brain, including during development, cyclin-dependent kinase-like 5 (CDKL5) remains a poorly characterized human protein kinase. Accordingly, its substrates, functions, and regulatory mechanisms ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbfb1603d4bbbd78dfe7ffaa08e876
https://doi.org/10.1101/2023.02.09.527935
https://doi.org/10.1101/2023.02.09.527935
SUMMARYNeurogenesis lasts ~10 times longer in developing humans compared to mice, resulting in >1000-fold more neurons in the human central nervous system. Expansion of human neocortex has been in part attributed to the population of outer radial gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6860b000d7d016ef0991b765a30c52f6
https://doi.org/10.1101/2022.07.05.498885
https://doi.org/10.1101/2022.07.05.498885
Autor:
Laurent Roybon, Nuno J. Lamas, Alejandro Garcia-Diaz, Eun Ju Yang, Rita Sattler, Vernice Jackson-Lewis, Yoon A. Kim, C. Alan Kachel, Jeffrey D. Rothstein, Serge Przedborski, Hynek Wichterle, Christopher E. Henderson
Publikováno v:
Cell Reports, Vol 4, Iss 5, Pp 1035-1048 (2013)
Differentiation of astrocytes from human stem cells has significant potential for analysis of their role in normal brain function and disease, but existing protocols generate only immature astrocytes. Using early neuralization, we generated spinal co
Externí odkaz:
https://doaj.org/article/be71f644a0784f3d84839de4950e4139
Autor:
Jennifer Hammelman, Hynek Wichterle, Tulsi Patel, Rachel Kopunova, David K. Gifford, Yuchun Guo, Esteban O. Mazzoni, Joriene C. de Nooij, Ping Wang, Sumin Jang, Yijun Ruan, Michael Closser
Publikováno v:
Neuron
Summary Proper assembly and function of the nervous system requires the generation of a uniquely diverse population of neurons expressing a cell-type-specific combination of effector genes that collectively define neuronal morphology, connectivity, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0ffb1102351f4191ffce28cdc25f03
https://europepmc.org/articles/PMC8738133/
https://europepmc.org/articles/PMC8738133/
Autor:
Aristotelis Tsirigos, Hynek Wichterle, Effie Apostolou, Boaz E. Aronson, Emily Swanzey, Abhishek Sinha, Rachel A. Glenn, Annabel Azziz, Veevek Shah, Laurianne Scourzic, Jiexi Li, Meelad M. Dawlaty, Matthias Stadtfeld, Inbal Caspi, Thomas Vierbuchen, Bobbie Pelham-Webb, Andreas Kloetgen, Alexander Polyzos
Publikováno v:
Dev Cell
3065.e5
Developmental cell
United States
3065.e5
Developmental cell
United States
Summary Loss of imprinting (LOI) results in severe developmental defects, but the mechanisms preventing LOI remain incompletely understood. Here, we dissect the functional components of the imprinting control region of the essential Dlk1-Dio3 locus (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812a52a1951b91516b84f961b573f74d
https://europepmc.org/articles/PMC8628258/
https://europepmc.org/articles/PMC8628258/