Výsledky vyhledávání - "Hymavathi Veeravarapu"

Structure-based drug design, synthesis and screening of MmaA1 inhibitors as novel anti-TB agents

Autor: Hymavathi Veeravarapu, Rajender Vadija, Uma Vuruputuri, Murali Krishna Kumar Muthyala, Vasavi Malkhed, Kiran Kumar Mustyala, Ramesh Malikanti

Publikováno v: Molecular Diversity. 25:351-366

Tuberculosis is one of the leading causes of death across the world. The treatment regimens for tuberculosis are well established, but still the control of the disease faces many challenges such as lengthy treatment protocols, drug resistance and tox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0686f9ebd7b20375280b770d65260d6
https://doi.org/10.1007/s11030-020-10107-0

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Design, synthesis, antimycobacterial activity and molecular docking studies of novel 3- (N-substituted glycinamido) benzoic acid analogues as anti tubercular agents

Autor: Sony Priya Kurati, Mohan Tirumalasetty, Umarani Wunnava, Hymavathi Veeravarapu, Murali Krishna Kumar Muthyala

Publikováno v: Bioorganicmedicinal chemistry letters. 30(23)

We have recently identified mycolic acid methyl transferase (MmaA1) enzyme inhibitors as potential antitubercular agents using in silico modelling techniques. In continuation of that study, we synthesised a series of novel 3-(N-substituted glycinamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8e3168e334d9fd3b2b075cd208a960e
https://pubmed.ncbi.nlm.nih.gov/33039564

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Identification of small molecular inhibitors for efflux protein Rv2688c of Mycobacterium tuberculosis

Autor: Rajender Vadija, Ramasree Dulapalli, Vasavi Malkhed, Hymavathi Veeravarapu, Uma Vuruputuri, Kiran Kumar Mustyala, Ramesh Malikanti

Publikováno v: Biotechnology and Applied Biochemistry. 65:608-621

Mycobacterium tuberculosis (Mtb) is the pathogen, which causes tuberculosis. The development of multidrug-resistant and extensively drug-resistant strains in Mtb is due to an efflux mechanism of antibiotics in the bacteria. The efflux pump proteins i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0c6216f7ba7d5311dd7677c5195090a
https://doi.org/10.1002/bab.1647

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Identification of small molecular ligands as potent inhibitors of fatty acid metabolism in Mycobacterium tuberculosis

Autor: Kiran Kumar Mustyala, Ramesh Malikanti, Uma Vuruputuri, Vasavi Malkhed, Hymavathi Veeravarapu, Rajender Vadija

Publikováno v: Journal of Molecular Structure. 1150:227-241

Tuberculosis (Tb) is one of the major health challenges for the global scientific community. The 3-hydroxy butyryl-CoA dehydrogenase (Fad B2) protein belongs to 3-hydroxyl acetyl-CoA dehydrogenase family, which plays a key role in the fatty acid meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9713303db1f8a137858fe278a396191
https://doi.org/10.1016/j.molstruc.2017.08.090

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