Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hylke de Jonge"'
Autor:
Henriette de Loor, Thomas Vanhove, Dirk Kuypers, Hylke de Jonge, Pieter Annaert, Ulf Diczfalusy
Publikováno v:
British Journal of Clinical Pharmacology. 82:1539-1549
Aims We compared the CYP3A4 metrics weight-corrected midazolam apparent oral clearance (MDZ Cl/F/W) and plasma 4β-hydroxycholesterol/cholesterol (4β-OHC/C) as they relate to tacrolimus (TAC) Cl/F/W in renal transplant recipients. Methods For a coho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24bf9bb4ac4f5abdc6b2cf20da0704f7
https://doi.org/10.1111/bcp.13083
https://doi.org/10.1111/bcp.13083
Autor:
Anton Pohanka, Pieter Annaert, Dirk Kuypers, Jan de Hoon, Thomas Vanhove, Hylke de Jonge, Marlies Oorts, Henriette de Loor
CYP3A5 genotype is a major determinant of tacrolimus clearance, and has been shown to affect systemic tacrolimus metabolite/parent ratios in healthy volunteers, which may have implications for efficacy and toxicity. In a cohort of 50 renal transplant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b80f0f3319b6fb426acd687b56bda95
https://lirias.kuleuven.be/handle/123456789/627987
https://lirias.kuleuven.be/handle/123456789/627987
Publikováno v:
British Journal of Clinical Pharmacology. 80:548-559
Aims The long-term disposition of tacrolimus following kidney transplantation is characterized by a gradual decrease in dose requirements and increase in dose-corrected exposure. This phenomenon has been attributed to a progressive decline in cytochr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1250270274c4693321ff84c05255892b
https://doi.org/10.1111/bcp.12703
https://doi.org/10.1111/bcp.12703
Autor:
Jan Verhaegen, Eline Macken, Daniël Van Caesbroeck, Dirk Kuypers, Dana Van Kerkhoven, Eric Van Wijngaerden, Hylke de Jonge
Publikováno v:
Transplantation Direct
Rhodococcus equi is an unusual cause of infection in humans, but has emerged as an opportunistic pathogen among immunocompromised patients. Primary pulmonary involvement is the most common clinical presentation, although the spectrum of disease is br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d579422308fbe62777a4915974a365d
https://doi.org/10.1097/txd.0000000000000519
https://doi.org/10.1097/txd.0000000000000519
Publikováno v:
Pharmacogenetics and Genomics. 24:597-606
In a cohort of 298 de-novo renal recipients treated with a standard tacrolimus loading dose of 0.2 mg/kg, the combined effects of the CYP3A5*1, POR*28, and CYP3A4*22 genotypes on early tacrolimus exposure (C0), dose requirements, and achievement of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f665720227b8a203dc441fe26f8e2fb8
https://doi.org/10.1097/fpc.0000000000000095
https://doi.org/10.1097/fpc.0000000000000095
Publikováno v:
Pharmacogenomics. 12:1281-1291
Aim: Recently a SNP of the gene encoding P450 oxidoreductase (POR*28; rs1057868C>T) has been associated with increased in vivo CYP3A activity using midazolam as a drug probe. Because tacrolimus is metabolized by CYP3A isoenzymes, this SNP might affec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08624227e6988ffbd12a8e0c8fc29db9
https://doi.org/10.2217/pgs.11.77
https://doi.org/10.2217/pgs.11.77
Publikováno v:
Biomedical Chromatography. 25:1091-1098
A highly sensitive liquid chromatography–tandem mass spectrometry method for the simultaneous quantification of midazolam and its major metabolites 1′-hydroxymidazolam and 4-hydroxymidazolam in human plasma was developed and validated. Stable iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73aa637bf0d604fe3acf325887d88d3e
https://doi.org/10.1002/bmc.1576
https://doi.org/10.1002/bmc.1576
Publikováno v:
Diagnostic Microbiology and Infectious Disease. 68:177-180
Dematiaceous molds are increasingly recognized as important human pathogens. We report 2 cases of cutaneous phaeohyphomycosis in renal allograft recipients, caused by Alternaria alternata and Curvularia spp., respectively, which demonstrate the diver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5af112d26a34aaad5c9bdf119706fd
https://doi.org/10.1016/j.diagmicrobio.2010.06.002
https://doi.org/10.1016/j.diagmicrobio.2010.06.002
Publikováno v:
Transplantation. 90:523-529
Background. Recently, a once-daily prolonged release formulation of tacrolimus (TacOD) has been approved for the prevention of renal allograft rejection. Studies reported equivalent area under the concentration-time curve 0-24 and predose trough (C 0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91a9b17902cc1a71cfd253e49b1da88
https://doi.org/10.1097/tp.0b013e3181e9feda
https://doi.org/10.1097/tp.0b013e3181e9feda
Autor:
Pieter Evenepoel, Bert Bammens, Björn Meijers, Maarten Naesens, Dirk Kuypers, Yves Vanrenterghem, Kathleen Claes, Hylke de Jonge
Publikováno v:
Clinical Journal of the American Society of Nephrology. 3:1829-1836
Background and objectives: In the first months after successful kidney transplantation, hypophosphatemia and renal phosphorus wasting are common and related to inappropriately high parathyroid hormone (PTH) and fibroblast growth factor-23 (FGF-23) le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d22485b0b9dde063ab00cbb5c5e13da
https://doi.org/10.2215/cjn.01310308
https://doi.org/10.2215/cjn.01310308