Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease

Autor: Theodore S. Kapellos, Kevin Baßler, Wataru Fujii, Christina Nalkurthi, Anna C. Schaar, Lorenzo Bonaguro, Tal Pecht, Izabela Galvao, Shobhit Agrawal, Adem Saglam, Erica Dudkin, Amit Frishberg, Elena de Domenico, Arik Horne, Chantal Donovan, Richard Y. Kim, David Gallego-Ortega, Tessa E. Gillett, Meshal Ansari, Jonas Schulte-Schrepping, Nina Offermann, Ignazio Antignano, Burcu Sivri, Wenying Lu, Mathew S. Eapen, Martina van Uelft, Collins Osei-Sarpong, Maarten van den Berge, Hylke C. Donker, Harry J.M. Groen, Sukhwinder S. Sohal, Johanna Klein, Tina Schreiber, Andreas Feißt, Ali Önder Yildirim, Herbert B. Schiller, Martijn C. Nawijn, Matthias Becker, Kristian Händler, Marc Beyer, Melania Capasso, Thomas Ulas, Jan Hasenauer, Carmen Pizarro, Fabian J. Theis, Philip M. Hansbro, Dirk Skowasch, Joachim L. Schultze

Publikováno v: Cell Reports, Vol 42, Iss 6, Pp 112525- (2023)

Summary: Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (C

Externí odkaz: https://doaj.org/article/de07677bc6c241f3a6d5cd66f2c12fd0

Multi-source data approach for personalized outcome prediction in lung cancer screening: update from the NELSON trial

Autor: Grigory Sidorenkov, Ralph Stadhouders, Colin Jacobs, Firdaus A.A. Mohamed Hoesein, Hester A. Gietema, Kristiaan Nackaerts, Zaigham Saghir, Marjolein A. Heuvelmans, Hylke C. Donker, Joachim G. Aerts, Roel Vermeulen, Andre Uitterlinden, Virissa Lenters, Jeroen van Rooij, Cornelia Schaefer-Prokop, Harry J.M. Groen, Pim A. de Jong, Robin Cornelissen, Mathias Prokop, Geertruida H. de Bock, Rozemarijn Vliegenthart

Publikováno v: European Journal of Epidemiology, 38(4), 445-454. SPRINGER
European Journal of Epidemiology, 38, 445-454
European Journal of Epidemiology, 38, 4, pp. 445-454
European Journal of Epidemiology, 38(4), 445-454. Springer, Cham
European Journal of Epidemiology, 38(4), 445-454. Springer Netherlands

Trials show that low-dose computed tomography (CT) lung cancer screening in long-term (ex-)smokers reduces lung cancer mortality. However, many individuals were exposed to unnecessary diagnostic procedures. This project aims to improve the efficiency

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3386224ab7ddbbc755bc21953ce6212
https://research.rug.nl/en/publications/68658692-2e2d-4cc5-a168-d70f4c3567c2

Decoding circulating tumor DNA to identify durable benefit from immunotherapy in lung cancer

Autor: Hylke C. Donker, Ed Schuuring, Ellen Heitzer, Harry J.M. Groen

Publikováno v: Lung Cancer, 170, 52-57. ELSEVIER IRELAND LTD

Objectives: Predicting the outcome of immunotherapy-treated non-small cell lung cancer (NSCLC) patients is challenging. Measuring circulating tumor DNA (ctDNA) in plasma is promising, but its application for outcome delineation needs further refineme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc8a7a84a1c5f5096f741422a2f7d88
https://research.rug.nl/en/publications/e7d58caf-7f0d-4425-93f3-05d9adbae458