Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.

Autor: Barrie W; Department of Zoology, University of Cambridge, Cambridge, UK.; Department of Genetics, University of Cambridge, Cambridge, UK., Yang Y; Department of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK.; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Irving-Pease EK; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Attfield KE; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Scorrano G; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Jensen LT; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark., Armen AP; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK., Dimopoulos EA; Pathogen Genomics and Evolution Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK., Stern A; Departments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA, USA., Refoyo-Martinez A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Pearson A; Department of Genetics, University of Cambridge, Cambridge, UK., Ramsøe A; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Gaunitz C; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Demeter F; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Eco-anthropologie (EA), Muséum National d'Histoire Naturelle, CNRS, Université de Paris, Musée de l'Homme, Paris, France., Jørkov MLS; Laboratory of Biological Anthropology, Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark., Møller SB; Ålborg Historiske Museum, Nordjyske Museer, Vestbjerg, Denmark., Springborg B; Ålborg Historiske Museum, Nordjyske Museer, Vestbjerg, Denmark., Klassen L; Museum Østdanmark-Djursland og Randers, Randers, Denmark., Hyldgård IM; Museum Østdanmark-Djursland og Randers, Randers, Denmark., Wickmann N; Museum Vestsjælland, Holbæk, Denmark., Vinner L; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Korneliussen TS; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Allentoft ME; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Trace and Environmental DNA (TrEnD) Laboratory, School of Molecular and Life Sciences, Curtin University, Perth, Western Australia, Australia., Sikora M; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark., Kristiansen K; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Department of Historical Studies, University of Gothenburg, Gothenburg, Sweden., Rodriguez S; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK., Nielsen R; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark.; Departments of Integrative Biology and Statistics, University of California, Berkeley, Berkeley, CA, USA., Iversen AKN; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. astrid.iversen@ndcn.ox.ac.uk.; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. astrid.iversen@ndcn.ox.ac.uk., Lawson DJ; Department of Statistical Sciences, School of Mathematics, University of Bristol, Bristol, UK. dan.lawson@bristol.ac.uk.; MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK. dan.lawson@bristol.ac.uk., Fugger L; Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. lars.fugger@ndcn.ox.ac.uk.; Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. lars.fugger@ndcn.ox.ac.uk.; MRC Human Immunology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK. lars.fugger@ndcn.ox.ac.uk., Willerslev E; Department of Zoology, University of Cambridge, Cambridge, UK. ew482@cam.ac.uk.; Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. ew482@cam.ac.uk.; MARUM Center for Marine Environmental Sciences and Faculty of Geosciences, University of Bremen, Bremen, Germany. ew482@cam.ac.uk.

Publikováno v: Nature [Nature] 2024 Jan; Vol. 625 (7994), pp. 321-328. Date of Electronic Publication: 2024 Jan 10.