Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hylar L Friedman"'
Autor:
Lisa C. Dogolo, Stuart I. Harris, John Vincent, Susan A. Willavize, George H Foulds, Hylar L Friedman
Publikováno v:
British Journal of Clinical Pharmacology. 50:455-463
Aims To determine whether repeated once daily administration of grapefruit juice altered the pharmacokinetics or pharmacodynamics of the calcium antagonist amlodipine. Methods The effects of grapefruit juice on the pharmacokinetics and pharmacodynami
Publikováno v:
The American Journal of Surgery. 176:8S-13S
Trovafloxacin, a new fluoronaphthyridone derivative related to fluoroquinolone antimicrobial drugs, has demonstrated the following characteristics: significant gram-positive and gram-negative activity; significant activity against anaerobes and atypi
Publikováno v:
The American Journal of Surgery. 176:23S-26S
Background Patients in the hospital, as well as those in home care settings, often require nutritional supplementation with enteral feeding solutions. In addition, patients with serious infections who are clinically unstable often cannot maintain ade
Publikováno v:
The American Journal of Surgery. 176:32S-38S
Background: Morphine and antibiotics are frequently coadministered in the surgical setting. These agents may interact, reducing the efficacy of the antibiotic or increasing the toxicity of morphine. It is therefore important to determine whether anti
Publikováno v:
Journal of Antimicrobial Chemotherapy. 39:87-92
Two studies determined the oral bioavailability of trovafloxacin (CP-99,219) in healthy volunteers under fasted and fed conditions. In a randomized, two-way crossover study, 12 fasting subjects received two 100 mg tablets of trovafloxacin and an equi
Autor:
R J Polzer, Renli Teng, Susan A. Willavize, Hylar L Friedman, B. A. Baris, J Venitz, John Vincent
Publikováno v:
Journal of Antimicrobial Chemotherapy. 39:75-80
Fifteen healthy male volunteers (in four groups) received single 1 h i.v. infusions of alatrofloxacin (CP-116,517) equivalent to 30, 100, 200 or 300 mg of its active metabolite, trovafloxacin (CP-99,219). Blood and urine were sampled over 73 and 72 h
Autor:
Richard I. Shader, Kathleen E. Corbett, Joseph M. Scavone, David J. Greenblatt, Hylar L Friedman, Kerry E. Culm, Bruce L. Ehrenberg, Jerold S. Harmatz
Publikováno v:
Journal of clinical pharmacology. 44(6)
The objective of this study was to evaluate the kinetics and dynamics of midazolam when administered by three different infusion schemes, using electroencephalography to measure pharmacodynamic effects. In a three-way crossover study, 8 volunteers re
Autor:
David J. Greenblatt, Bruce L. Ehrenberg, Kerry E. Culm, Joseph M. Scavone, Kathleen E. Corbett, Hylar L. Friedman, Jerold S. Harmatz, Richard I. Shader
Publikováno v:
Journal of Clinical Pharmacology; Jun2004, Vol. 44 Issue 6, p605-611, 7p
Publikováno v:
The Journal of antimicrobial chemotherapy. 39
To determine the effect of the concurrent administration of Maalox and omeprazole in the bioavailability of trovafloxacin (CP-99,219), an open, placebo-controlled, randomized, four-way crossover study was conducted in 12 healthy male volunteers. Each
Publikováno v:
The Journal of antimicrobial chemotherapy. 39
Some fluoroquinolone antibiotics interfere with theophylline clearance, thereby raising concentrations of circulating theophylline and increasing the potential for toxicity. The effect of steady-state serum concentrations of the new fluoroquinolone t