Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hyking Haley"'
Autor:
Michal R. Tomaszewski, Alexander L. Sukstanskii, Hyking Haley, Xiangjun Meng, Corin O. Miller, Dmitriy A. Yablonskiy
Publikováno v:
NeuroImage, Vol 298, Iss , Pp 120794- (2024)
Robust methods are needed for preclinical evaluation of novel Alzheimer Disease (AD) therapies to accelerate drug discovery. Quantitative Gradient Recalled Echo (qGRE) MRI has shown promise to provide insight into neurodegeneration in AD prior to atr
Externí odkaz:
https://doaj.org/article/aef6c483f9084e05bdd928adfab0bc1f
Autor:
Mary Wolf, Idriss Bennacef, Hyking Haley, Terence G. Hamill, G Wesolowski, Shawn J. Stachel, Le T. Duong, Mangay Williams, Diane J. Posavec, Mona Purcell, Eric D. Hostetler, Jeffrey L. Evelhoch, Marie A. Holahan, Daniel Rubins, Laura S. Lubbers, Kerry Riffel
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 64:159-167
The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery and clinical evaluations of a CatK inhibitor, we sought to discover a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d62580f174113b1cfb6b8736aeffe3e
https://doi.org/10.1002/jlcr.3896
https://doi.org/10.1002/jlcr.3896
Autor:
Brett Connolly, Stacey O'Malley, Michael Klimas, Jeffrey L. Evelhoch, Daniel Rubins, Caroline Ekblad, Marie A. Holahan, Mona Purcell, Paul McQuade, Eric D. Hostetler, Dinko Gonzalez Trotter, Fredrik Y. Frejd, Shu-An Lin, Xiangjun Meng, Pär Eklund, Joel Lindgren, Liza Gantert, Hyking Haley, Krista L. Getty
Publikováno v:
Molecular Imaging and Biology. 23:241-249
In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron emiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbd09e0daa50d49b59cd6e61006e6f2
https://doi.org/10.1007/s11307-020-01544-2
https://doi.org/10.1007/s11307-020-01544-2
Autor:
John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley
Publikováno v:
Journal of Medicinal Chemistry. 63:2411-2425
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949c4dbede58ed2de44d27f608635d36
https://doi.org/10.1021/acs.jmedchem.9b01406
https://doi.org/10.1021/acs.jmedchem.9b01406
Autor:
Wenping, Li, Yuchuan, Wang, Talakad G, Lohith, Zhizhen, Zeng, Ling, Tong, Robert, Mazzola, Kerry, Riffel, Patricia, Miller, Mona, Purcell, Marie, Holahan, Hyking, Haley, Liza, Gantert, David, Hesk, Sumei, Ren, John, Morrow, Jason, Uslaner, Arie, Struyk, Jenny Miu-Chun, Wai, Michael T, Rudd, David M, Tellers, Thomas, McAvoy, Guy, Bormans, Michel, Koole, Koen, Van Laere, Kim, Serdons, Jan, de Hoon, Ruben, Declercq, Inge, De Lepeleire, Maria B, Pascual, Paolo, Zanotti-Fregonara, Meixiang, Yu, Victoria, Arbones, Joseph C, Masdeu, Amy, Cheng, Azher, Hussain, Tjerk, Bueters, Matt S, Anderson, Eric D, Hostetler, Anthony S, Basile
Publikováno v:
Science translational medicine. 14(627)
Positron emission tomography (PET) ligands play an important role in the development of therapeutics by serving as target engagement or pharmacodynamic biomarkers. Here, we describe the discovery and translation of the PET tracer [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4a48387c373777e91d8509feb8c9c29
https://pubmed.ncbi.nlm.nih.gov/35020407
https://pubmed.ncbi.nlm.nih.gov/35020407
Autor:
Wenping Li, Yuchuan Wang, Talakad G. Lohith, Zhizhen Zeng, Ling Tong, Robert Mazzola, Kerry Riffel, Patricia Miller, Mona Purcell, Marie Holahan, Hyking Haley, Liza Gantert, David Hesk, Sumei Ren, John Morrow, Jason Uslaner, Arie Struyk, Jenny Miu-Chun Wai, Michael T. Rudd, David M. Tellers, Thomas McAvoy, Guy Bormans, Michel Koole, Koen Van Laere, Kim Serdons, Jan de Hoon, Ruben Declercq, Inge De Lepeleire, Maria B. Pascual, Paolo Zanotti-Fregonara, Meixiang Yu, Victoria Arbones, Joseph C. Masdeu, Amy Cheng, Azher Hussain, Tjerk Bueters, Matt S. Anderson, Eric D. Hostetler, Anthony S. Basile
Positron emission tomography (PET) ligands play an important role in the development of therapeutics by serving as target engagement or pharmacodynamic biomarkers. Here, we describe the discovery and translation of the PET tracer [11C]MK-6884 from rh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e44197a5317a5a2a9f28fb0766d601b
https://lirias.kuleuven.be/handle/20.500.12942/688229
https://lirias.kuleuven.be/handle/20.500.12942/688229
Autor:
Daniel J, Rubins, Xiangjun, Meng, Paul, McQuade, Michael, Klimas, Krista, Getty, Shu-An, Lin, Brett M, Connolly, Stacey S, O'Malley, Hyking, Haley, Mona, Purcell, Liza, Gantert, Marie, Holahan, Joel, Lindgren, Pär, Eklund, Caroline, Ekblad, Fredrik Y, Frejd, Eric D, Hostetler, Dinko E, González Trotter, Jeffrey L, Evelhoch
Publikováno v:
Molecular imaging and biology. 23(2)
In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron emiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92e9c29eb62cb12b8b8bb175e9390d4f
https://pubmed.ncbi.nlm.nih.gov/33098025
https://pubmed.ncbi.nlm.nih.gov/33098025
Autor:
Wenping, Li, Yuchuan, Wang, Daniel, Rubins, Idriss, Bennacef, Marie, Holahan, Hyking, Haley, Mona, Purcell, Liza, Gantert, SuChun, Hseih, Michael, Judo, Wolfgang, Seghezzi, Shuli, Zhang, Elly L, van der Veen, Marjolijn N, Lub-de Hooge, Elisabeth G E, de Vries, Jeffrey L, Evelhoch, Michael, Klimas, Eric D, Hostetler
Publikováno v:
Molecular Imaging and Biology
Purpose Programmed cell death-1 receptor (PD-1) and its ligand (PD-L1) are the targets for immunotherapy in many cancer types. Although PD-1 blockade has therapeutic effects, the efficacy differs between patients. Factors contributing to this variabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8db8b78a03a9404b4b89044a2035502
https://pubmed.ncbi.nlm.nih.gov/33104972
https://pubmed.ncbi.nlm.nih.gov/33104972
Autor:
Ling, Tong, Wenping, Li, Michael Man-Chu, Lo, Xiaolei, Gao, Jenny Miu-Chen, Wai, Michael, Rudd, David, Tellers, Aniket, Joshi, Zhizhen, Zeng, Patricia, Miller, Cristian, Salinas, Kerry, Riffel, Hyking, Haley, Mona, Purcell, Marie, Holahan, Liza, Gantert, Jeffrey W, Schubert, Kristen, Jones, James, Mulhearn, Melissa, Egbertson, Zhaoyang, Meng, Barbara, Hanney, Robert, Gomez, Scott T, Harrison, Paul, McQuade, Tjerk, Bueters, Jason, Uslaner, John, Morrow, Fiona, Thomson, Jongrock, Kong, Jing, Liao, Oleg, Selyutin, Jianming, Bao, Nicholas B, Hastings, Sony, Agrawal, Brian C, Magliaro, Frederick J, Monsma, Michelle D, Smith, Stefania, Risso, David, Hesk, Eric, Hostetler, Robert, Mazzola
Publikováno v:
Journal of medicinal chemistry. 63(5)
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd3ef3c047c980065bd64efde0a0b7e9
https://pubmed.ncbi.nlm.nih.gov/32101422
https://pubmed.ncbi.nlm.nih.gov/32101422
Autor:
Qingshou Chen, Daniel Rubins, Shu-An Lin, Xiangjun Meng, Hyking Haley, Philip S. Low, Dinko Gonzalez Trotter, Paul McQuade, Patricia Miller, Zhizhen Zeng
Publikováno v:
Molecular Pharmaceutics. 14:4353-4361
The folate receptor (FR) has been established as a promising target for imaging and therapy of cancer (FR-α), inflammation, and autoimmune diseases (FR-β). Several folate-based PET radiotracers have been reported in the literature, but an 18F- labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71a929949dc874ec56666ea8d7775c08
https://doi.org/10.1021/acs.molpharmaceut.7b00415
https://doi.org/10.1021/acs.molpharmaceut.7b00415