Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Hyeyoung Nam"'
Autor:
Hyeyoung Nam, Anirban Kundu, Suman Karki, Garrett J. Brinkley, Darshan S. Chandrashekar, Richard L. Kirkman, Juan Liu, Maria V. Liberti, Jason W. Locasale, Tanecia Mitchell, Sooryanarayana Varambally, Sunil Sudarshan
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is ret
Externí odkaz:
https://doaj.org/article/eb7183e5d0134cfe9561270e096c17b2
Autor:
Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M. Tennessen, Juan Liu, Jason W. Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L. Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K. Challa, Sunil Sudarshan
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 11 (2020)
L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Dro
Externí odkaz:
https://doaj.org/article/6dd4f46ccd38444ea52f902f75ef43e0
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86019 (2014)
It is well known that iron overload can result in pancreatic iron deposition, beta-cell destruction, and diabetes in humans. Recent studies in animals have extended the link between iron status and pancreatic function by showing that iron depletion c
Externí odkaz:
https://doaj.org/article/a3f77a35e95c466b85bb6593b8a6f955
Autor:
Hyeyoung Nam, Chia-Yu Wang, Lin Zhang, Wei Zhang, Shintaro Hojyo, Toshiyuki Fukada, Mitchell D. Knutson
Publikováno v:
Haematologica, Vol 98, Iss 7 (2013)
The liver, pancreas, and heart are particularly susceptible to iron-related disorders. These tissues take up plasma iron from transferrin or non-transferrin-bound iron, which appears during iron overload. Here, we assessed the effect of iron status o
Externí odkaz:
https://doaj.org/article/a3b57ec3435241d49bca0f935b3f5e3e
Autor:
Garrett Brinkley, Anirban Kundu, Hyeyoung Nam, Suman Karki, Richard Kirkman, Hayley Widden, Michelle Johnson, Juan Liu, Yasaman Heidarian, Nader Mahmoudzadeh, Devin Absher, Han-Fei Ding, David Crosman, William Placzek, Jason Locasale, Dinesh Rakheja, Victor Darley-Usmar, Jason Tennessen, Sunil Sudarshan
Publikováno v:
Journal of Urology. 209
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::984fc635216adb158ea9f24e591090b6
https://doi.org/10.1097/ju.0000000000003272.08
https://doi.org/10.1097/ju.0000000000003272.08
Autor:
Suman Karki, Anirban Kundu, Garret Brinkley, Hyeyoung Nam, Kayla Goliwas, Jessy Deshane, Sunil Sudarshan
Publikováno v:
Cancer Research. 83:3702-3702
Tumor cells are known to have increased demand for nutrients to support proliferation. Among the most highly utilized nutrients by tumor cells are nonessential amino acids (NEAAs). While the role of NEAAs in supporting tumor growth is well-establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19be4c1d16c4f9e7478b4e9cc192d88e
https://doi.org/10.1158/1538-7445.am2023-3702
https://doi.org/10.1158/1538-7445.am2023-3702
Autor:
Anirban Kundu, Garrett J. Brinkley, Hyeyoung Nam, Suman Karki, Richard Kirkman, Hayley Widden, Michelle Johnson, Juan Liu, Yasaman Heidarian, Nader Mahmoudzadeh, Devin Absher, Han-Fei Ding, David Crosman, William J. Placzek, Jason Locasale, Dinesh Rakheja, Victor Darley-Usmar, Jason Tennessen, Sunil Sudarshan
Publikováno v:
Cancer Research. 83:3705-3705
The oncometabolite, L-2-hydroxyglutarate (L-2HG) is elevated in the most common form of renal cell carcinoma-RCC (clear cell histology) and promotes tumor progression. L-2HG is structurally similar to α-ketoglutarate (α-KG). Therefore, L-2HG can co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b6526d5cd6f5e82483bd7747677c28
https://doi.org/10.1158/1538-7445.am2023-3705
https://doi.org/10.1158/1538-7445.am2023-3705
Autor:
Mary E. Ballestas, Sooryanarayana Varambally, Suman Karki, Richard Kirkman, Anirban Kundu, Sejong Bae, Arindam P. Ghosh, Sunil Sudarshan, Sandeep B. Shelar, Hyeyoung Nam, Garrett J. Brinkley, James A. Mobley
Publikováno v:
J Biol Chem
Ten-eleven translocation-2 (TET2) is a member of the methylcytosine dioxygenase family of enzymes and has been implicated in cancer and aging because of its role as a global epigenetic modifier. TET2 has a large N-terminal domain and a catalytic C-te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57d44986a95b83689e98d14e46450491
https://doi.org/10.1074/jbc.ra119.011089
https://doi.org/10.1074/jbc.ra119.011089
Autor:
Anirban Kundu, Sunil Sudarshan, Richard Kirkman, Sooryanarayana Varambally, Suman Karki, Juan Liu, Darshan S. Chandrashekar, Tanecia Mitchell, Maria V. Liberti, Garrett J. Brinkley, Jason W. Locasale, Hyeyoung Nam
Publikováno v:
JCI Insight
Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272536e3a0af30a29d698d1947d24960
http://europepmc.org/articles/PMC8663777
http://europepmc.org/articles/PMC8663777
Autor:
Darshan S. Chandrashekar, Hyeyoung Nam, Maria V. Liberti, Tanecia Mitchell, Juan Liu, Sooryanarayana Varambally, Suman Karki, Anirban Kundu, Jason W. Locasale, Garrett J. Brinkley, Richard Kirkman, Sunil Sudarshan
The Warburg effect is one of most-well studied metabolic phenomenon in cancer cells. For the most part, these studies have focused on enhanced rates of glycolysis observed in various models. The presumption has been that mitochondrial metabolism is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f1295bdc946aa41e922159b1e9a945f
https://doi.org/10.1101/2021.02.19.429599
https://doi.org/10.1101/2021.02.19.429599
