Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Hyesook Yoon"'
Autor:
Erin M. Triplet, Ha Neui Kim, Hyesook Yoon, Maja Radulovic, Laurel Kleppe, Whitney L. Simon, Chan-il Choi, Patrick J. Walsh, James R. Dutton, Isobel A. Scarisbrick
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105294- (2021)
Despite concerted efforts to identify CNS regeneration strategies, an incomplete understanding of how the needed molecular machinery is regulated limits progress. Here we use models of lateral compression and FEJOTA clip contusion-compression spinal
Externí odkaz:
https://doaj.org/article/a29ff409f6b7437b94b16c1317730dcb
Autor:
Ha Neui Kim, Monica R. Langley, Whitney L. Simon, Hyesook Yoon, Laurel Kleppe, Ian R. Lanza, Nathan K. LeBrasseur, Aleksey Matveyenko, Isobel A. Scarisbrick
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104934- (2020)
A diet high in fat and sucrose (HFHS), the so-called Western diet promotes metabolic syndrome, a significant co-morbidity for individuals with spinal cord injury (SCI). Here we demonstrate that the spinal cord of mice consuming HFHS expresses reduced
Externí odkaz:
https://doaj.org/article/881bfc9a8a2f4d62ab095bd6e962bda3
Publikováno v:
Neurobiology of Disease, Vol 93, Iss , Pp 226-242 (2016)
The deregulation of serine protease activity is a common feature of neurological injury, but little is known regarding their mechanisms of action or whether they can be targeted to facilitate repair. In this study we demonstrate that the thrombin rec
Externí odkaz:
https://doaj.org/article/5ee76fa0dcfa4001816a8cf643ce169f
Autor:
Maja Radulovic, Hyesook Yoon, Jianmin Wu, Karim Mustafa, Michael G. Fehlings, Isobel A. Scarisbrick
Publikováno v:
Neurobiology of Disease, Vol 83, Iss , Pp 75-89 (2015)
Inflammatory-astrogliosis exacerbates damage in the injured spinal cord and limits repair. Here we identify Protease Activated Receptor 2 (PAR2) as an essential regulator of these events with mice lacking the PAR2 gene showing greater improvements in
Externí odkaz:
https://doaj.org/article/d47a062d20944b5b81bbc841abda47c0
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180697 (2017)
Astrocytes have emerged as essential regulators of function and response to injury in the brain and spinal cord, yet very little is known about regional differences that exist. Here we compare the expression of key astroglial markers (glial fibrillar
Externí odkaz:
https://doaj.org/article/f56f941daa3141ba8dec952d30016e17
Autor:
Isobel A Scarisbrick, Benjamin Epstein, Beth A Cloud, Hyesook Yoon, Jianmin Wu, Danielle N Renner, Sachiko I Blaber, Michael Blaber, Alexander G Vandell, Alexandra L Bryson
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18376 (2011)
Kallikrein 6 (KLK6) is a newly identified member of the kallikrein family of secreted serine proteases that prior studies indicate is elevated at sites of central nervous system (CNS) inflammation and which shows regulated expression with T cell acti
Externí odkaz:
https://doaj.org/article/cb202fbf74964e07b536e229ae68bf9d
Autor:
Claudia F. Lucchinetti, Chan Il Choi, Hyesook Yoon, Monica R. Langley, Isobel A. Scarisbrick, Laurel S. Kleppe, Whitney L. Simon, Claudia C.S. Chini, Eduardo N. Chini, Yong Guo, Thais Peclat
Publikováno v:
The Journal of Neuroscience. 41:8644-8667
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinam
Autor:
Whitney L. Simon, Elena De Vita, Aubry K. Miller, Erin M. Triplet, Isobel A. Scarisbrick, Chan Il Choi, Hyesook Yoon, Laurel S. Kleppe
Publikováno v:
Glia
Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To gain insights into the significance of Klk6 to oligodendrocyte biology, we investigated the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6358ef97af4b3fea36da9e948704ab
https://europepmc.org/articles/PMC8732303/
https://europepmc.org/articles/PMC8732303/
Autor:
Monica R, Langley, Chan-Il, Choi, Thais R, Peclat, Yong, Guo, Whitney L, Simon, Hyesook, Yoon, Laurel, Kleppe, Claudia F, Lucchinetti, Claudia C S, Chini, Eduardo N, Chini, Isobel A, Scarisbrick
Publikováno v:
J Neurosci
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinam
Autor:
Chan-Il Choi, Thais Peclat, Monica R. Langley, Whitney L. Simon, Laurel S. Kleppe, Hyesook Yoon, Claudia C.S. Chini, Eduardo N. Chini, Yong Guo, Claudia F. Lucchinetti, Isobel A. Scarisbrick
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. CD38 has increased expression in the cuprizone and EAE demyelination models and is the main NAD+ depleting enzyme in CNS tissue. Altered NAD+ metabolism h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb7156efd1556bc2f167c7e993bdf33
https://doi.org/10.1101/2020.06.10.143941
https://doi.org/10.1101/2020.06.10.143941