Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells

Autor: Wenxin Song, Anne P. Beigneux, Anne-Marie L. Winther, Kristian K. Kristensen, Anne L. Grønnemose, Ye Yang, Yiping Tu, Priscilla Munguia, Jazmin Morales, Hyesoo Jung, Pieter J. de Jong, Cris J. Jung, Kazuya Miyashita, Takao Kimura, Katsuyuki Nakajima, Masami Murakami, Gabriel Birrane, Haibo Jiang, Peter Tontonoz, Michael Ploug, Loren G. Fong, Stephen G. Young

Publikováno v: The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)

GPIHBP1, an endothelial cell (EC) protein, captures lipoprotein lipase (LPL) within the interstitial spaces (where it is secreted by myocytes and adipocytes) and transports it across ECs to its site of action in the capillary lumen. GPIHBP1’s 3-fin

Externí odkaz: https://doaj.org/article/4780a6e489eb4eb2947f3a57c5c18c7c

Progerin forms an abnormal meshwork and has a dominant-negative effect on the nuclear lamina.

Autor: Kim, Paul H., Kim, Joonyoung R., Yiping Tu, Hyesoo Jung, Jeong, J. Y. Brian, Tran, Anh P., Presnell, Ashley, Young, Stephen G., Fong, Loren G.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America; 7/2/2024, Vol. 121 Issue 27, p1-12, 29p

Design Improvement of AIU to Reduce Communication Noise of Rotorcraft

Autor: Wonae Son, Jung-Min Kim, Hyesoo Jung

Publikováno v: Journal of the Korea Academia-Industrial cooperation Society. 23:587-593

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::497dc43ab65002f9bcd911083bcb1947
https://doi.org/10.5762/kais.2022.23.11.587

Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures

Autor: Wenxin Song, Ye Yang, Patrick Heizer, Yiping Tu, Thomas A. Weston, Joonyoung R. Kim, Priscilla Munguia, Hyesoo Jung, Jared L.-C. Fong, Caitlyn Tran, Michael Ploug, Anne P. Beigneux, Stephen G. Young, Loren G. Fong

Publikováno v: Song, W, Yang, Y, Heizer, P, Tu, Y, Weston, T A, Kim, J R, Munguia, P, Jung, H, Fong, J L C, Tran, C, Ploug, M, Beigneux, A P, Young, S G & Fong, L G 2023, ' Intracapillary LPL levels in brown adipose tissue, visualized with an antibody-based approach, are regulated by ANGPTL4 at thermoneutral temperatures ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 8, e2219833120 . https://doi.org/10.1073/pnas.2219833120

Lipoprotein lipase (LPL) is secreted into the interstitial spaces by parenchymal cells and then transported into capillaries by GPIHBP1. LPL carries out the lipolytic processing of triglyceride (TG)-rich lipoproteins (TRLs), but the tissue-specific r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee0bd61ac352612dab52cbff6fb337f
https://doi.org/10.1073/pnas.2219833120

CSgator: an integrated web platform for compound set analysis

Autor: Yeajee Kwon, Sera Park, Haeseung Lee, Wankyu Kim, Hyesoo Jung, Sukyung Jang

Publikováno v: Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-8 (2019)
Journal of Cheminformatics

Drug discovery typically involves investigation of a set of compounds (e.g. drug screening hits) in terms of target, disease, and bioactivity. CSgator is a comprehensive analytic tool for set-wise interpretation of compounds. It has two unique analyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda5bbad755aa15237fb01c21403224b
http://link.springer.com/article/10.1186/s13321-019-0339-6