Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hyeseok Shim"'
Autor:
Theresa D. Manz, Tinghu Zhang, Anton Simeonov, Chandrasekhar V. Miduturu, Lewis C. Cantley, Adam Yasgar, Hyeseok Shim, Nathanael S. Gray, Sirano Dhe-Paganon, Sindhu Carmen Sivakumaren, Joseph D. Card, Scott B. Ficarro, Min Shen, Hyuk-Soo Seo, Jarrod A. Marto, Matthew D. Hall, Fleur M. Ferguson
Publikováno v:
Journal of Medicinal Chemistry. 63:4880-4895
Due to their role in many important signaling pathways, phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are attractive targets for the development of experimental therapeutics for cancer, metabolic, and immunological disorders. Recent efforts to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43a16faa83e838e7b651e0a9e516b30d
https://doi.org/10.1021/acs.jmedchem.0c00227
https://doi.org/10.1021/acs.jmedchem.0c00227
Autor:
Fleur M. Ferguson, Hyeseok Shim, Adam Yasgar, Min Shen, Matthew D. Hall, Sirano Dhe-Paganon, Nathanael S. Gray, Scott B. Ficarro, Jarrod A. Marto, Sindhu Carmen Sivakumaren, Joseph D. Card, Matthew B. Boxer, Theresa D. Manz, Anton Simeonov, Atsuo T. Sasaki, Hyuk-Soo Seo, Mindy I. Davis, Tinghu Zhang, Lewis C. Cantley
Publikováno v:
ACS Med Chem Lett
[Image: see text] Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are important molecular players in a variety of diseases, such as cancer. Currently available PI5P4K inhibitors are reversible small molecules, which may lack selectivity and suff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6566158355189dbcd449bd5dc1306768
https://doi.org/10.1021/acsmedchemlett.9b00402
https://doi.org/10.1021/acsmedchemlett.9b00402
Autor:
Sirano Dhe-Paganon, Theresa D. Manz, Lewis C. Cantley, Scott B. Ficarro, Hyuk-Soo Seo, Marcia N. Paddock, Mingfeng Hao, Nathanael S. Gray, Tinghu Zhang, Baishan Jiang, Hyeseok Shim, Jarrod A. Marto, Nicholas Kwiatkowski, Diana G. Wang, Christopher M. Browne, James M. Cunningham, T. Jonathan Yang, Sindhu Carmen Sivakumaren, Mark R. Lundquist, Fleur M. Ferguson, Pranav Krishnan
SummaryThe PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these kinases is understudied due to a lack of potent, specific small molecules available. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc1b0cef434a17aa0f69572842f5ff5
Autor:
Nathanael S. Gray, Lewis C. Cantley, Christopher M. Browne, Theresa D. Manz, Jarrod A. Marto, Hyeseok Shim, Pranav Krishnan, Diana G. Wang, Scott B. Ficarro, Nicholas Kwiatkowski, James M. Cunningham, Mark R. Lundquist, Fleur M. Ferguson, Hyuk-Soo Seo, Mingfeng Hao, Marcia N. Paddock, T. Jonathan Yang, Sindhu Carmen Sivakumaren, Baishan Jiang, Sirano Dhe-Paganon, Tinghu Zhang
Publikováno v:
Cell Chem Biol
The PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these kinases is understudied due to a lack of potent, specific small molecules available. Here, we p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c61db14f9907d78cc5960d931fcf67
https://doi.org/10.1016/j.chembiol.2020.02.003
https://doi.org/10.1016/j.chembiol.2020.02.003
Autor:
Lewis C. Cantley, Zhiwei Yang, Gerburg M. Wulf, Brooke M. Emerling, Hui Liu, Chuan Wu, Vijay K. Kuchroo, Kaitlyn Bosch, Jihye Yun, Hyeseok Shim, Rayman Choo-Wing, Zuojia Chen, Shivan Ramsamooj
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(27)
Type 2 phosphatidylinositol-5-phosphate 4-kinase (PI5P4K) converts phosphatidylinositol-5-phosphate to phosphatidylinositol-4,5-bisphosphate. Mammals have three enzymes PI5P4Kα, PI5P4Kβ, and PI5P4Kγ, and these enzymes have been implicated in metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae92d17b110ecddb401060f647dc70ae
https://pubmed.ncbi.nlm.nih.gov/27313209
https://pubmed.ncbi.nlm.nih.gov/27313209
Autor:
Lewis C. Cantley, Albert S. Yu, Kannan Karukarichi, Fredrik Karlsson, Ellen Santangelo, Rui Wang, F. Rahm, Ulrika Ericsson, Johan Linstrom, Mariell Pettersson, Jessica Martinsson, Tiago Braga, Madeleine Livendahl, Aine Brigette Henley, Horst Wähling, Lars Boukharta Persson, Martin Andersson, Tobias Ginman, Andreas Hoglund, Parisa Zolfaghari, Rickard Forsblom, Jenny Viklund, Lionel Trésaugues, David L. McElligott, Hyeseok Shim, Antoine Talagas, Tommy Johansson, Kesicki Edward A
Publikováno v:
Blood. 132:213-213
Phosphoinositide signaling is central to many cellular processes including the cell survival pathway known as autophagy. While there is evidence that autophagy can suppress tumorigenesis under certain circumstances, there is increasingly abundant evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::867bf56f13fc1acc910e2fea63856a46
https://doi.org/10.1182/blood-2018-99-118355
https://doi.org/10.1182/blood-2018-99-118355
Autor:
John M. Asara, Rayman Choo-Wing, Lewis C. Cantley, Gerburg M. Wulf, Kazumi S. Tsukazawa, Eric L. Bell, Jiaxi Song, Victoria Brown, Hyeseok Shim, Sabina Signoretti, Xin Yuan, Lucia E. Rameh, Andrea J. Bullock, George Poulogiannis, Jonathan Hurov, Atsuo T. Sasaki, Brooke M. Emerling, Katja A. Lamia, Gary Bellinger, Gina M. DeNicola
Publikováno v:
Cell. 155(4)
Summary Here, we show that a subset of breast cancers express high levels of the type 2 phosphatidylinositol-5-phosphate 4-kinases α and/or β (PI5P4Kα and β) and provide evidence that these kinases are essential for growth in the absence of p53.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b52857e0ebed57d419fa7627c3cd2a9
https://pubmed.ncbi.nlm.nih.gov/24304875
https://pubmed.ncbi.nlm.nih.gov/24304875
Autor:
Lewis C. Cantley, Gina M. DeNicola, Katja A. Lamia, Sabina Signoretti, Brooke M. Emerling, Jiaxi Song, George Poulogiannis, Rayman Choo-Wing, Xin Yuan, Gerburg M. Wulf, Hyeseok Shim, Lucia E. Rameh, Andrea J. Bullock, Jonathan Hurov
Publikováno v:
Cancer Research. 74:NG05-NG05
The phosphoinositide family of lipids includes seven derivatives of phosphatidylinositol (PI) that are formed through the phosphorylation of the 3-, 4-, and 5-positions on the inositol ring. Phosphoinositides have distinct biological roles and regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee7951e9ea2a69de5e61d54f955c8061
https://doi.org/10.1158/1538-7445.am2014-ng05
https://doi.org/10.1158/1538-7445.am2014-ng05
Autor:
Hyeseok Shim, Chuan Wu, Ramsamooj, Shivan, Bosch, Kaitlyn N., Zuojia Chen, Emerling, Brooke M., Jihye Yun, Hui Liu, Rayman Choo-Wing, Zhiwei Yang, Wulf, Gerburg M., Kuchroo, Vijay Kumar, Cantley, Lewis C.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/5/2016, Vol. 113 Issue 27, p7596-7601, 6p