Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hyeongil Kwak"'
Autor:
Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D Tran, Taekyu Ha, Jing‐Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-21 (2021)
Abstract The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor‐tyrosine‐kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remode
Externí odkaz:
https://doaj.org/article/18628d9234a14174a940d08372600b84
Autor:
Michael DiPrima, Dunrui Wang, Alix Tröster, Dragan Maric, Nekane Terrades‐Garcia, Taekyu Ha, Hyeongil Kwak, David Sanchez‐Martin, Denis Kudlinzki, Harald Schwalbe, Giovanna Tosato
Publikováno v:
Molecular Oncology, Vol 13, Iss 11, Pp 2441-2459 (2019)
Advanced colorectal carcinoma is currently incurable, and new therapies are urgently needed. We report that phosphotyrosine‐dependent Eph receptor signaling sustains colorectal carcinoma cell survival, thereby uncovering a survival pathway active i
Externí odkaz:
https://doaj.org/article/8f5f33f7824b4646a48a5bac962048a5
Autor:
Giovanna Tosato, Dragan Maric, David Sánchez-Martín, Hyeongil Kwak, Ombretta Salvucci, Dunrui Wang, Kan Jiang, Hidetaka Ohnuki
PDF file - 1522KB, Supplementary Figure S1: shows the kinetics of EL4, LLC1 and B16F10 tumor growth in WT and Gfi1-KO mice. Supplemental Figure S2: analysis of EL4 and LLC1 tumor vascularization (A); distribution and typical profiles of CD11b+Ly6C+Ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e28a530fef2e77ea6d0171b86221c
https://doi.org/10.1158/0008-5472.22401303
https://doi.org/10.1158/0008-5472.22401303
Autor:
Giovanna Tosato, Dragan Maric, David Sánchez-Martín, Hyeongil Kwak, Ombretta Salvucci, Dunrui Wang, Kan Jiang, Hidetaka Ohnuki
Myeloid cells that orchestrate malignant progression in the tumor microenvironment offer targets for a generalized strategy to attack solid tumors. Through an analysis of tumor microenvironments, we explored an experimental model of lung cancer that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d861aa96bd18a466617c5326df26d7c
https://doi.org/10.1158/0008-5472.c.6505812
https://doi.org/10.1158/0008-5472.c.6505812
Autor:
Jingxin Feng, Yuyi Wang, Andy D. Tran, Diprima Michael J, Taekyu Ha, Giovanna Tosato, Hidetaka Ohnuki, Hyeongil Kwak, Ombretta Salvucci, Dunrui Wang, Michael J. Kruhlak
The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor-tyrosine-kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remodeling tumor va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ee87ddb43d837b5c2f7f403c4855e4
https://doi.org/10.1101/2020.10.06.327882
https://doi.org/10.1101/2020.10.06.327882
Autor:
Roberto Weigert, Hyeongil Kwak, Michael G. Poulos, Jorge L. Martínez-Torrecuadrada, Giovanna Tosato, Jason M. Butler, Ombretta Salvucci, Mark Henkemeyer
Publikováno v:
Journal of Clinical Investigation. 126:4554-4568
Hematopoietic stem and progenitor cells (HSPCs) reside in the bone marrow. Stress signals from cancer and other conditions promote HSPC mobilization into circulation and subsequent homing to tissue microenvironments. HSPC infiltration into tissue mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009a68d1ffc94181f445e62834450a84
https://doi.org/10.1172/jci87848
https://doi.org/10.1172/jci87848
Autor:
Hidetaka Ohnuki, Karen Aleman, Robert Yarchoan, Vickie Marshall, Thomas S. Uldrick, Mark N. Polizzotto, Denise Whitby, Hyeongil Kwak, Mark Raffeld, Christina M. Annunziata, David Sánchez-Martín, Victoria Wang, Giovanna Tosato, Kathleen M. Wyvill
Publikováno v:
JNCI: Journal of the National Cancer Institute. 109
Background Primary effusion lymphoma (PEL) is a Kaposi's sarcoma herpes virus (KSHV)-induced lymphoma that typically arises in body cavities of HIV-infected patients. PEL cells are often co-infected with Epstein-Barr virus (EBV). "PEL-like" lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb5d311b14962aa4aa452448018f946
https://doi.org/10.1093/jnci/djx016
https://doi.org/10.1093/jnci/djx016
Autor:
Dunrui Wang, Ombretta Salvucci, Giovanna Tosato, Kan Jiang, Dragan Maric, Hyeongil Kwak, David Sánchez-Martín, Hidetaka Ohnuki
Publikováno v:
Cancer Research. 74:2038-2049
Myeloid cells that orchestrate malignant progression in the tumor microenvironment offer targets for a generalized strategy to attack solid tumors. Through an analysis of tumor microenvironments, we explored an experimental model of lung cancer that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206af1d7f1f971ce32b71c57b5012f12
https://doi.org/10.1158/0008-5472.can-13-3118
https://doi.org/10.1158/0008-5472.can-13-3118
Autor:
Inn-Inn Chen, Catherine Porcher, Hyeongil Kwak, Hidetaka Ohnuki, Giovanna Tosato, Arianna Caprioli
Publikováno v:
Scientific Reports
Adult-type intraembryonic hematopoiesis arises from specialized endothelial cells of the dorsal aorta (DA). Despite the critical importance of this specialized endothelium for establishment of hematopoietic stem cells and adult hematopoietic lineages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d6a6d1034e5fd1b62ad1b3e3fc77ee
https://doi.org/10.1038/srep27195
https://doi.org/10.1038/srep27195
Autor:
Giovanna Tosato, Ombretta Salvucci, Hyeongil Kwak, Georgina Espígol-Frigolé, Maria C. Cid, Sarangan Ravichandran, Hidetaka Ohnuki, Ester Planas-Rigol, Brian T. Luke
Publikováno v:
Science Signaling. 9
Interleukin-23 (IL-23), a heterodimeric cytokine composed of the unique p19 peptide (IL-23p19) and a peptide called IL-12p40, which is shared with IL-12, is implicated in Crohn's disease, rheumatoid arthritis, psoriasis, and other immune-mediated inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a59ed298affa270e16fb9fc91b5eb77
https://doi.org/10.1126/scisignal.aad2357
https://doi.org/10.1126/scisignal.aad2357