Zobrazeno 1 - 10
of 42
pro vyhledávání: '"HyeonJoo Cheon"'
Autor:
Sebastian Wienerroither, Priyank Shukla, Matthias Farlik, Andrea Majoros, Bernadette Stych, Claus Vogl, HyeonJoo Cheon, George R. Stark, Birgit Strobl, Mathias Müller, Thomas Decker
Publikováno v:
Cell Reports, Vol 12, Iss 2, Pp 300-312 (2015)
The transcriptional response to infection with the bacterium Listeria monocytogenes (Lm) requires cooperative signals of the type I interferon (IFN-I)-stimulated JAK-STAT and proinflammatory NF-κB pathways. Using ChIP-seq analysis, we define genes i
Externí odkaz:
https://doaj.org/article/3ee79a746fcc4926a1c0b0f3308ef0b4
Publikováno v:
Trends Cancer
Acute exposure of cancer cells to high concentrations of type I interferon (IFN-I) drives growth arrest and apoptosis, whereas chronic exposure to low concentrations provides important prosurvival advantages. Tyrosine-phosphorylated IFN-stimulated ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c449259e718a7fa344f3c3dfc45df1c
https://europepmc.org/articles/PMC9797472/
https://europepmc.org/articles/PMC9797472/
Autor:
Rachael L. Philips, Yuxin Wang, HyeonJoo Cheon, Yuka Kanno, Massimo Gadina, Vittorio Sartorelli, Curt M. Horvath, James E. Darnell, George R. Stark, John J. O’Shea
Publikováno v:
Cell
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals
Publikováno v:
Proc Natl Acad Sci U S A
Programmed death ligand 1 (PD-L1), an immune-checkpoint protein expressed on cancer cells, also functions independently of the immune system. We found that PD-L1 inhibits the killing of cancer cells in response to DNA damage in an immune-independent
Autor:
Anna Kondratova, HyeonJoo Cheon, Beihua Dong, Elise G Holvey‐Bates, Metis Hasipek, Irina Taran, Christina Gaughan, Babal K Jha, Robert H Silverman, George R Stark
Publikováno v:
The EMBO Journal. 39
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 11/23/2021, Vol. 118 Issue 47, p1-10, 10p
Autor:
Do Youn Park, Hyung Il Seo, Seung Kew Yoon, Su-Hyung Park, George R. Stark, Chung Hwan Cho, Pil Soo Sung, Eui-Cheol Shin, HyeonJoo Cheon, Seon Hui Hong
Publikováno v:
Proceedings of the National Academy of Sciences. 112:10443-10448
Up-regulation of IFN-stimulated genes (ISGs) is sustained in hepatitis C virus (HCV)-infected livers. Here, we investigated the mechanism of prolonged ISG expression and its role in IFN responsiveness during HCV infection in relation to unphosphoryla
Autor:
Paola Pellegrini, Stig Linder, Slavica Brnjic, Katja Pokrovskaja Tamm, Hanif Rassoolzadeh, Dan Grandér, Sofi Forsberg, Rolf Larsson, Elin Edsbäcker, Elise G. Holvey-Bates, Angelo De Milito, George Stark Stark, Iryna Kolosenko, HyeonJoo Cheon, Per Johnsson, Mårten Fryknäs
Publikováno v:
International Journal of Cancer. 136:E51-E61
The mechanism of multicellular drug resistance, defined as the reduced efficacy of chemotherapeutic drugs in solid tumors is incompletely understood. Here we report that colon carcinoma cells cultured as 3D microtissues (spheroids) display dramatic i
Publikováno v:
Proceedings of the National Academy of Sciences. 110:16975-16980
The activation of STAT3 by tyrosine phosphorylation, essential for normal development and for a normal inflammatory response to invading pathogens, is kept in check by negative regulators. Abnormal constitutive activation of STAT3, which contributes
Autor:
John W. Schoggins, Naoko Imanaka, Charles M. Rice, Samuel C. Forster, Mark W. Jackson, George R. Stark, Damian J. Junk, Paul J. Hertzog, HyeonJoo Cheon, Elise G. Holvey-Bates
Publikováno v:
The EMBO Journal
A single high dose of interferon-β (IFNβ) activates powerful cellular responses, in which many anti-viral, pro-apoptotic, and anti-proliferative proteins are highly expressed. Since some of these proteins are deleterious, cells downregulate this in