Treatment of Prion Disease with Heterologous Prion Proteins.

Autor: Pamela J Skinner, Hyeon O Kim, Damani Bryant, Nikilyn J Kinzel, Cavan Reilly, Suzette A Priola, Anne E Ward, Patricia A Goodman, Katherine Olson, Davis M Seelig

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0131993 (2015)

Prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy in cattle, and scrapie in sheep are fatal neurodegenerative diseases for which there is no effective treatment. The pathology of these diseases involves the

Externí odkaz: https://doaj.org/article/ff529682102349ca81df3b8145aeb0f7

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge.

Autor: Arun K Sasikala-Appukuttan, Hyeon O Kim, Nikilyn J Kinzel, Jung Joo Hong, Anthony J Smith, Reece Wagstaff, Cavan Reilly, Michael Piatak, Jeffrey D Lifson, R Keith Reeves, R Paul Johnson, Ashley T Haase, Pamela J Skinner

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e81623 (2013)

Live-attenuated SIV vaccines (LAVs) have been the most effective to date in preventing or partially controlling infection by wild-type SIV in non-human primate models of HIV-1 transmission to women acting by mechanisms of protection that are not well

Externí odkaz: https://doaj.org/article/dab9cf6b95514747a0684e994a02c800

Compartmentalization of simian immunodeficiency virus replication within secondary lymphoid tissues of rhesus macaques is linked to disease stage and inversely related to localization of virus-specific CTL

Autor: Brodie Miles, Eva G. Rakasz, Hadia M. Abdelaal, Kimberly Schmitt, Elizabeth Connick, Joy M. Folkvord, Mario L. Santiago, Hyeon O. Kim, Pamela J. Skinner, Katherine T. Lind, Reece K. Wagstaff, Samantha MaWhinney, Shengbin Li, Nancy A. Wilson, David I. Watkins, Edward B. Stephens, Nathan Kemp

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 193(11)

We previously demonstrated that HIV replication is concentrated in lymph node B cell follicles during chronic infection and that HIV-specific CTL fail to accumulate in large numbers at those sites. It is unknown whether these observations can be gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22abec8a1df2bed6fee85fbed1a73fec
https://pubmed.ncbi.nlm.nih.gov/25362178

Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms

Autor: Bruce Chesebro, Hyeon O. Kim, Pamela J. Skinner, Richard E. Race, Tyler M Blazey, Greg P Snyder

Publikováno v: Advances and Applications in Bioinformatics and Chemistry, Vol 2008, Iss default, Pp 29-50 (2008)
Advances and applications in bioinformatics and chemistry : AABC

Hyeon O Kim1, Greg P Snyder1, Tyler M Blazey1, Richard E Race2, Bruce Chesebro2, Pamela J Skinner11Department of Veterinary and Biomedical Sciences, University of Minnesota, USA; 2NIH Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd754fba8850ff33c8884d9fba6181a
https://www.dovepress.com/prion-disease-induced-alterations-in-gene-expression-in-spleen-and-bra-peer-reviewed-article-AABC

Comparison of Vibratome and Compresstome sectioning of fresh primate lymphoid and genital tissues for in situ MHC-tetramer and immunofluorescence staining

Autor: Pamela J. Skinner, Peter J. Southern, Hadia M. Abdelaal, Reece K. Wagstaff, Hyeon O. Kim, Ryoko Sawahata

Publikováno v: Biological Procedures

Background For decades, the Vibratome served as a standard laboratory resource for sectioning fresh and fixed tissues. In skilled hands, high quality and consistent fresh unfixed tissue sections can be produced using a Vibratome but the sectioning pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c59223c431e0edc52be9aadd1c67ec