Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hyeon Joon Kong"'
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 679-696 (2021)
The acquisition of chemoresistance remains a major cause of cancer mortality due to the limited accessibility of targeted or immune therapies. However, given that severe alterations of molecular features during epithelial‐to‐mesenchymal transitio
Externí odkaz:
https://doaj.org/article/34b15c9e56bc4925bbe359f4f2330c65
Autor:
Ok-Seon Kwon, Eun-Ji Kwon, Hyeon-Joon Kong, Jeong-Yoon Choi, Yun-Jeong Kim, Eun-Woo Lee, Wankyu Kim, Haeseung Lee, Hyuk-Jin Cha
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101719- (2020)
Erastin, a synthetic lethal compound against cancer expressing an oncogenic RAS, inhibits cystine/glutamate antiporters and causes ferroptosis. However, despite recent evidence for the mechanisms underlying ferroptosis, molecular biomarkers of erasti
Externí odkaz:
https://doaj.org/article/9f43a3232f5943e0bce94ef45fafad38
Autor:
Young-Hyun Go, Hyo-Ju Lee, Hyeon-Joon Kong, Ho-Chang Jeong, Dong Young Lee, Soon-Ki Hong, Sang Hyun Sung, Ok-Seon Kwon, Hyuk-Jin Cha
Publikováno v:
Royal Society Open Science, Vol 5, Iss 12 (2018)
The Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) system can be used not only to study gene expression at a specific cell cycle stage, but also to monitor cell cycle transitions in real time. In this study, we used a single clone of F
Externí odkaz:
https://doaj.org/article/73015de21a2a450c8ff0cd08a0c04f00
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 679-696 (2021)
Molecular Oncology
Molecular Oncology
Through integration of multiple large database, two oncogenic signatures (YAP conserved and TGFβ‐up signatures) were commonly upregulated in the cancer cell lines with the mesenchymal properties. AXL, the expression of which is highly induced in E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a5f4f3bfb8b236c1ae2e38c5ec5d7a
https://doaj.org/article/34b15c9e56bc4925bbe359f4f2330c65
https://doaj.org/article/34b15c9e56bc4925bbe359f4f2330c65
Autor:
Jeong‑Yun Choi, Hyuk-Jin Cha, Ok Seon Kwon, Haeseung Lee, Wankyu Kim, Yung‑Jeong Kim, Hyeon Joon Kong, Eun Ji Kwon
Publikováno v:
International Journal of Oncology. 58:111-121
Serpin family E member 1 (SERPINE1), a serine proteinase inhibitor, serves as an important regulator of extracellular matrix remodeling. Emerging evidence suggests that SERPINE1 has diverse roles in cancer and is associated with poor prognosis. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5733e73ce7c1e0bf97c6b022468dfcc6
https://doi.org/10.3892/ijo.2020.5153
https://doi.org/10.3892/ijo.2020.5153
Autor:
Hyuk-Jin Cha, Yun Jeong Kim, Eun-Woo Lee, Jeong Yoon Choi, Haeseung Lee, Wankyu Kim, Hyeon Joon Kong, Eun Ji Kwon, Ok Seon Kwon
Publikováno v:
Redox Biology, Vol 37, Iss, Pp 101719-(2020)
Redox Biology
Redox Biology
Erastin, which has been initially identified as a synthetic lethal compound against cancer expressing an RAS oncogene, inhibits cystine/glutamate antiporters and causes ferroptic cell death in various cell types, including therapy-resistant mesenchym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea8faa6357662d44ac9d122c019be925
http://www.sciencedirect.com/science/article/pii/S2213231720309241
http://www.sciencedirect.com/science/article/pii/S2213231720309241
Autor:
Ok-Seon, Kwon, Haeseung, Lee, Hyeon-Joon, Kong, Eun-Ji, Kwon, Ji Eun, Park, Wooin, Lee, Seungmin, Kang, Mirang, Kim, Wankyu, Kim, Hyuk-Jin, Cha
Publikováno v:
Oncogene. 39(23)
Despite the continual discovery of promising new cancer targets, drug discovery is often hampered by the poor druggability of these targets. As such, repurposing FDA-approved drugs based on cancer signatures is a useful alternative to cancer precisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::feb33fb64b65bc8751ff0a80156b2c20
https://pubmed.ncbi.nlm.nih.gov/33574481
https://pubmed.ncbi.nlm.nih.gov/33574481
Autor:
Ji Eun Park, Seungmin Kang, Haeseung Lee, Wankyu Kim, Eun Ji Kwon, Ok Seon Kwon, Mirang Kim, Wooin Lee, Hyeon Joon Kong, Hyuk-Jin Cha
Publikováno v:
Oncogene. 40:1921-1921
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c025568bf59886cf55345911e9440d8
https://doi.org/10.1038/s41388-021-01642-7
https://doi.org/10.1038/s41388-021-01642-7
Autor:
Won-Ki Kim, Hyung Joon Cha, Heeyeon Lee, Mun-Ock Kim, Ok-Seon Kwon, Wang Jae Lee, Shin Wook Kang, Ji Eun Park, Hyeon-Joon Kong
Although many molecular targets for cancer therapy have been discovered, they often show poor druggability, which is a major obstacle to develop targeted drugs. As an alternative route to drug discovery, we adopted anin silicodrug repositioning (in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4ed532df9cdfb2b78d31fff3301e53
Autor:
Go, Young-Hyun, Hyo-Ju Lee, Hyeon-Joon Kong, Ho-Chang Jeong, Lee, Dong Young, Soon-Ki Hong, Sung, Sang Hyun, Ok-Seon Kwon, Hyuk-Jin Cha
The fluorescence-ubiquitin cell cycle indicator (FUCCI) system can be used not only to study gene expression at a specific cell cycle stage, but also to monitor cell cycle transitions in real time. In this study, we used a single clone of FUCCI-expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c3858ef797b8d51a13c73da5238241