Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hyeon Gyeom Choi"'
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2195 (2023)
Tofacitinib, an inhibitor of Janus kinases (JAKs) 1 and 3, has been shown to be effective in the treatment of rheumatoid arthritis. The incidence of hyperlipidemia has been found to be higher in patients with rheumatoid arthritis. The present study t
Externí odkaz:
https://doaj.org/article/03aed39c290e4ebe982f308e3e502034
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2684 (2022)
Tofacitinib, a Janus kinase 1 and 3 inhibitor, is used to treat rheumatoid arthritis. It is mainly metabolized by the cytochromes p450 (CYP) 3A1/2 and CYP2C11 in the liver. Chronic inflammation eventually leads to cirrhosis in patients with rheumatoi
Externí odkaz:
https://doaj.org/article/fe33308a8e25453a8c041e668fe8419d
Publikováno v:
Pharmaceutics, Vol 13, Iss 5, p 740 (2021)
Fungal infections are prevalent in patients with immune diseases. Voriconazole, a triazole antifungal drug, inhibits the cytochromes CYP3A4 and CYP2C, and tofacitinib, a Janus kinase inhibitor for the treatment of rheumatoid arthritis, is metabolized
Externí odkaz:
https://doaj.org/article/cd6c894ead1f4a1f87ebca8a55d0e6a3
Autor:
Julia Matzenbacher dos Santos, Alan Dombkowski, David Putt, Guoan Chen, Hyeon-Gyeom Choi, Sohee Kim, David G Beer, Hyesook Kim
Background: The majority of lung cancer patients are diagnosed at an advanced or metastatic stage and their 5-year survival rate is < 5%. However, when patients are diagnosed at an early stage, Stage I, they have ~70% 5-year survival rate. The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30dabcb6ebfa5438a523fc1994663e87
https://doi.org/10.21203/rs.3.rs-2035334/v1
https://doi.org/10.21203/rs.3.rs-2035334/v1
Publikováno v:
Biomoleculestherapeutics. 30(6)
Tofacitinib, a Janus kinase 1 and 3 inhibitor, is mainly metabolized by CYP3A1/2 and CYP2C11 in the liver. The drug has been approved for the chronic treatment of severe ulcerative colitis, a chronic inflammatory bowel disease. This study investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9c3daf6a5ae7ac54b38576bc086500
https://pubmed.ncbi.nlm.nih.gov/35811297
https://pubmed.ncbi.nlm.nih.gov/35811297
Publikováno v:
Pharmaceutics, Vol 13, Iss 740, p 740 (2021)
Pharmaceutics
Volume 13
Issue 5
Pharmaceutics
Volume 13
Issue 5
Fungal infections are prevalent in patients with immune diseases. Voriconazole, a triazole antifungal drug, inhibits the cytochromes CYP3A4 and CYP2C, and tofacitinib, a Janus kinase inhibitor for the treatment of rheumatoid arthritis, is metabolized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca50ccda4da145c162c8626d7893adb5
https://www.mdpi.com/1999-4923/13/5/740
https://www.mdpi.com/1999-4923/13/5/740
Publikováno v:
Biomolecules & Therapeutics
Breast cancer is currently the most prevalent cancer in women, and its incidence increases every year. Azole antifungal drugs were recently found to have antitumor efficacy in several cancer types. They contain an imidazole (clotrimazole and ketocona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a55a96ba57e140404886012086ef1f2
https://doi.org/10.4062/biomolther.2018.042
https://doi.org/10.4062/biomolther.2018.042
Publikováno v:
Oncology Reports. 36:1119-1126
Butyrate is a short-chain fatty acid produced by the intestinal microflora and it not only induces apoptosis but also inhibits the proliferation of cancer cells. Recently, it has been reported that butyrate may cause resistance in colon cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae5041a302a48bb1a369bd8f08dce24
https://doi.org/10.3892/or.2016.4838
https://doi.org/10.3892/or.2016.4838
Publikováno v:
Oncology reports. 33(4)
The MCF10AT cell series of human breast epithelial cancer cells includes normal MCF10A (10A), premalignant MCF10AT (10AT) and MCF10ATG3B (10ATG3B), and fully malignant MCF10CA1a (10CA1a) cells. The series is a unique model system showing progressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187292b64e8a8a439b35c2c00ce3fae3
https://pubmed.ncbi.nlm.nih.gov/25647149
https://pubmed.ncbi.nlm.nih.gov/25647149
Publikováno v:
Oncology reports. 29(3)
Etoposide, used for the treatment of breast cancer, is mainly metabolized via hepatic cytochrome P450 (CYP) 3A4 in humans and is also a substrate for p-glycoprotein (P-gp). Morin is known to be able to modulate the activities of metabolic enzymes inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1affcdb9088f250136c4a0ab16278e13
https://pubmed.ncbi.nlm.nih.gov/23254912
https://pubmed.ncbi.nlm.nih.gov/23254912