Neurotoxic Microglial Activation via IFNγ‐Induced Nrf2 Reduction Exacerbating Alzheimer's Disease.

Autor: Kang, You Jung^1,2 (AUTHOR), Hyeon, Seung Jae³ (AUTHOR), McQuade, Amanda^4,5,6,7 (AUTHOR), Lim, Jiwoon^8,9 (AUTHOR), Baek, Seung Hyun¹⁰ (AUTHOR), Diep, Yen N.^1,2,11 (AUTHOR), Do, Khanh V.^1,11 (AUTHOR), Jeon, Yeji¹⁰ (AUTHOR), Jo, Dong‐Gyu^10,12,13 (AUTHOR), Lee, C. Justin⁹ (AUTHOR), Blurton‐Jones, Mathew^5,6,7 (AUTHOR), Ryu, Hoon³ (AUTHOR), Cho, Hansang^1,2,11 (AUTHOR) h.cho@g.skku.edu

Publikováno v: Advanced Science. 5/28/2024, Vol. 11 Issue 20, p1-13. 13p.

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EWSR1, a multifunctional protein, regulates cellular function and aging via genetic and epigenetic pathways

Autor: Lee, Junghee, Nguyen, Phuong T., Shim, Hyun Soo, Hyeon, Seung Jae, Im, Hyeonjoo, Choi, Mi-Hyun, Chung, Sooyoung, Kowall, Neil W., Lee, Sean Bong, Ryu, Hoon

Publikováno v: In BBA - Molecular Basis of Disease 1 July 2019 1865(7):1938-1945

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington's disease mouse model.

Autor: Hwang, Yu Jin¹ (AUTHOR), Hyeon, Seung Jae¹ (AUTHOR), Kim, Younghee¹ (AUTHOR), Lim, Sungsu² (AUTHOR), Lee, Min Young³ (AUTHOR), Kim, Jieun¹ (AUTHOR), Londhe, Ashwini M.^2,4 (AUTHOR), Gotina, Lizaveta^2,4 (AUTHOR), Kim, Yunha¹ (AUTHOR), Pae, Ae Nim^2,4 (AUTHOR), Cho, Yong Seo^1,4 (AUTHOR), Seong, Jihye^2,4 (AUTHOR), Seo, Hyemyung⁵ (AUTHOR), Kim, Yun Kyung^2,4 (AUTHOR), Choo, Hyunah^1,4 (AUTHOR), Ryu, Hoon^1,6 (AUTHOR), Min, Sun-Joon⁷ (AUTHOR)

Publikováno v: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2021, Vol. 36 Issue 1, p856-868. 13p.

Additional file 1 of Modulation of histone H3K4 dimethylation by spermidine ameliorates motor neuron survival and neuropathology in a mouse model of ALS

Autor: Choi, Seung-Hye, Yousefian-Jazi, Ali, Hyeon, Seung Jae, Nguyen, Phuong Thi Thanh, Chu, Jiyeon, Kim, Sojung, Kim, Suhyun, Ryu, Hannah L., Kowall, Neil W., Ryu, Hoon, Lee, Junghee

Additional file 1: Fig. S1. LSD1 is induced in a cellular model of ALS (N2a cell line). A, LSD1 immunoreactivity (red) was increased in the nucleus of mSOD1 (G85R) N2a cell line. The nucleus was counterstained with DAPI (blue). B, The densitometry an

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