Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Hyemyung Seo"'
Autor:
Xiaona Chen, Jing Sun, Tian Wang, Qingyuan Tang, Lu Su, Yimin Sun, Liang Chen, Hyemyung Seo, Tianlin Cheng, Jian Wang, Bin Song
Publikováno v:
Stem Cell Research, Vol 77, Iss , Pp 103419- (2024)
Mutations in CHCHD2 have been reported to be associated with familial Parkinson’s disease (PD). We generated a human induced pluripotent stem cell (hiPSC) line by reprogramming dermal fibroblasts from a PD patient harboring a novel CHCHD2 mutation
Externí odkaz:
https://doaj.org/article/6fadaa70fe4f467d85de72a521c85c34
Autor:
Yu Jin Hwang, Seung Jae Hyeon, Younghee Kim, Sungsu Lim, Min Young Lee, Jieun Kim, Ashwini M. Londhe, Lizaveta Gotina, Yunha Kim, Ae Nim Pae, Yong Seo Cho, Jihye Seong, Hyemyung Seo, Yun Kyung Kim, Hyunah Choo, Hoon Ryu, Sun-Joon Min
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 856-868 (2021)
The present study describes evaluation of epigenetic regulation by a small molecule as the therapeutic potential for treatment of Huntington’s disease (HD). We identified 5-allyloxy-2-(pyrrolidin-1-yl)quinoline (APQ) as a novel SETDB1/ESET inhibito
Externí odkaz:
https://doaj.org/article/53eb5263e2d44245a87e4c6d821bd071
Autor:
Jihoon Jang, Hakjin Oh, Daleum Nam, Wongi Seol, Mi Kyoung Seo, Sung Woo Park, Hyung Gun Kim, Hyemyung Seo, Ilhong Son, Dong Hwan Ho
Publikováno v:
Animal Cells and Systems, Vol 22, Iss 5, Pp 273-280 (2018)
Leucine-rich repeat kinase 2 (LRRK2) is involved in Parkinson’s disease (PD) pathology. A previous study showed that rotenone treatment induced apoptosis, mitochondrial damage, and nucleolar disruption via up-regulated LRRK2 kinase activity, and th
Externí odkaz:
https://doaj.org/article/9feb4789e01948629aca6824ea330f2e
Publikováno v:
Parkinson's Disease, Vol 2018 (2018)
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Oxidative stress is the most critical risk factor for neurodegenerative diseases, including Alzheimer’s disease (AD) and Huntington’s disease (HD). Numerous reports h
Externí odkaz:
https://doaj.org/article/2b3a508ec0684c02ab3a8793c26a46e9
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136950 (2015)
The activity of beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is elevated during aging and in sporadic Alzheimer's disease (AD), but the underlying mechanisms of this change are not well understood. p25/Cyclin-dependent kinase 5
Externí odkaz:
https://doaj.org/article/8fb3d412664947a0aa68b6ce14a1ba23
Autor:
Dong Hwan Ho, Hyejung Kim, Jisun Kim, Hyuna Sim, Hyunjun Ahn, Janghwan Kim, Hyemyung Seo, Kwang Chul Chung, Bum-Joon Park, Ilhong Son, Wongi Seol
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-1 (2017)
Externí odkaz:
https://doaj.org/article/11135be40c3444fc99edc5f7f1ed6e77
Publikováno v:
PLoS ONE, Vol 2, Iss 2, p e238 (2007)
In patients with Huntington's disease (HD), the proteolytic activity of the ubiquitin proteasome system (UPS) is reduced in the brain and other tissues. The pathological hallmark of HD is the intraneuronal nuclear protein aggregates of mutant hunting
Externí odkaz:
https://doaj.org/article/f1d34262fd66492384871d787e241826
Publikováno v:
Journal of Colloid and Interface Science. 645:663-675
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f791e39dc17829f6bd0f56bf3d8c83c
https://doi.org/10.1016/j.jcis.2023.04.161
https://doi.org/10.1016/j.jcis.2023.04.161
Autor:
Jisun Kim, Jeha Jeon, Bin Song, Nayeon Lee, Sanghyeok Ko, Young Cha, Pierre Leblanc, Hyemyung Seo, Kwang-Soo Kim
Publikováno v:
Nat Protoc
To fully realize the potential of human pluripotent stem cells (hPSCs) for both therapeutic and research purposes it is critical to follow an efficient and reliable in vitro differentiation method that is based on optimal physical, chemical, and deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7888122b2205dc979e8ff05a02a3bb
https://doi.org/10.1038/s41596-021-00673-4
https://doi.org/10.1038/s41596-021-00673-4
Autor:
So Yeon Yu, Eun Jung Koh, Seung Hwan Kim, Byeongwook Song, Ji Su Lee, Sang Wook Son, Hyemyung Seo, Seung Yong Hwang
Publikováno v:
Environmental Toxicology. 37:802-813
Environmentally hazardous substances and exposure to these can cause various diseases. Volatile organic compounds can easily evaporate into the atmosphere, thereby exerting toxic effects through either the skin or respiratory tract exposures. Toluene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3495a0e29e2b8e935c86e4f66dfd1073
https://doi.org/10.1002/tox.23444
https://doi.org/10.1002/tox.23444