Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Hyejung Park"'
Autor:
Gabriel C. Baccam, Jian Xie, Xin Jin, Hyejung Park, Bing Wang, Hervé Husson, Oxana Ibraghimov-Beskrovnaya, Chou-Long Huang
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract A significant population of patients with chronic kidney disease (CKD) develops cardiac hypertrophy, which can lead to heart failure and sudden cardiac death. Soluble klotho (sKL), the shed ectodomain of the transmembrane protein klotho, pro
Externí odkaz:
https://doaj.org/article/dc4c66cb84784ecfa69801c093ee0755
Publikováno v:
Journal of Intensive Care, Vol 10, Iss 1, Pp 1-10 (2022)
Abstract Objective Delirium in the intensive care unit (ICU) may be a preventable risk factor for cognitive impairment or psychiatric problems. We aimed to evaluate the association between the presence of delirium during hospitalization involving ICU
Externí odkaz:
https://doaj.org/article/7181f50c15e242b8a51689d2bdeeda33
Autor:
Young Eun Huh, Hyejung Park, Ming Sum Ruby Chiang, Idil Tuncali, Ganqiang Liu, Joseph J. Locascio, Julia Shirvan, Samantha J. Hutten, Melissa S. Rotunno, Catherine Viel, Lamya S. Shihabuddin, Bing Wang, Sergio Pablo Sardi, Clemens R. Scherzer
Publikováno v:
npj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract Protein-coding variants in the GBA gene modulate susceptibility and progression in ~10% of patients with Parkinson’s disease (PD). GBA encodes the β-glucocerebrosidase enzyme that hydrolyzes glucosylceramide. We hypothesized that GBA muta
Externí odkaz:
https://doaj.org/article/55051a3035eb4ec194cc1bc0ad51cd1d
Autor:
Catherine Viel, Jennifer Clarke, Can Kayatekin, Amy M. Richards, Ming Sum R. Chiang, Hyejung Park, Bing Wang, Lamya S. Shihabuddin, S. Pablo Sardi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Mutations in GBA, the gene encoding the lysosomal enzyme glucocerebrosidase (GCase), represent the greatest genetic risk factor for developing synucleinopathies including Parkinson’s disease (PD). Additionally, PD patients harboring a muta
Externí odkaz:
https://doaj.org/article/c4a35b81ff05400cb0b27881077b5aa3
Autor:
Eva Zaccariotto, María Begoña Cachón-González, Bing Wang, Sungtaek Lim, Bradford Hirth, Hyejung Park, Malika Fezoui, S.Pablo Sardi, Paul Mason, Robert H. Barker, Jr, Timothy M. Cox
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 149, Iss , Pp 112808- (2022)
Krabbe disease is a rare, inherited neurodegenerative disease due to impaired lysosomal β-galactosylceramidase (GALC) activity and formation of neurotoxic β-galactosylsphingosine (‘psychosine’). We investigated substrate reduction therapy with
Externí odkaz:
https://doaj.org/article/77cf7efe886d460196850a21fcc8a250
Autor:
Richard Lieberman, Leslie K. Cortes, Grace Gao, Hyejung Park, Bing Wang, Patrick L. Jones, R. Bridge Hunter, John P. Leonard, Robert H. Barker
Publikováno v:
PLoS ONE, Vol 17, Iss 8 (2022)
Globoid cell leukodystrophy (Krabbe disease) is a fatal neurodegenerative, demyelinating disease caused by dysfunctional activity of galactosylceramidase (GALC), leading to the accumulation of glycosphingolipids including psychosine. While oligodendr
Externí odkaz:
https://doaj.org/article/00ddfe55df1b4645bbda90c529f4c8ba
Autor:
Kanghyeon Seo, Bokjin Chung, Hamsa Priya Panchaseelan, Taewoo Kim, Hyejung Park, Byungmo Oh, Minho Chun, Sunjae Won, Donkyu Kim, Jaewon Beom, Doyoung Jeon, Jihoon Yang
Publikováno v:
Diagnostics, Vol 11, Iss 6, p 1096 (2021)
Cerebrovascular accidents (CVA) cause a range of impairments in coordination, such as a spectrum of walking impairments ranging from mild gait imbalance to complete loss of mobility. Patients with CVA need personalized approaches tailored to their de
Externí odkaz:
https://doaj.org/article/da6c9a0dca604cfcabf691f1c051a82e
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 4, Pp 773-781 (2014)
Gangliosides and sulfatides (STs) are acidic glycosphingolipids (GSLs) that have one or more sialic acids or sulfate substituents, in addition to neutral sugars, attached to the C-1 hydroxyl group of the ceramide long chain base. TLC is a widely empl
Externí odkaz:
https://doaj.org/article/e01dd0125d484abdb5472d71762a3575
Autor:
Amin A. Momin, Hyejung Park, Brent J. Portz, Christopher A. Haynes, Rebecca L. Shaner, Samuel L. Kelly, I. King Jordan, Jr Alfred H. Merrill
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 6, Pp 1073-1083 (2011)
Sphingolipids are structurally diverse and their metabolic pathways highly complex, which makes it difficult to follow all of the subspecies in a biological system, even using “lipidomic” approaches. This report describes a method to use transcri
Externí odkaz:
https://doaj.org/article/382e91e162e54709ae2abcf45f16cf1a
Autor:
Alexander Y. Andreyev, Eoin Fahy, Ziqiang Guan, Samuel Kelly, Xiang Li, Jeffrey G. McDonald, Stephen Milne, David Myers, Hyejung Park, Andrea Ryan, Bonne M. Thompson, Elaine Wang, Yihua Zhao, H. Alex Brown, Alfred H. Merrill, Christian R.H. Raetz, David W. Russell, Shankar Subramaniam, Edward A. Dennis
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2785-2797 (2010)
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual
Externí odkaz:
https://doaj.org/article/adbe8420d4aa463597dc770bc8c69ae5