Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Hyebeen Hong"'
Autor:
Hyebeen Hong, Yoontae Lee
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101526- (2022)
Summary: Hematopoietic lineage cell-specific transgenic or knockout mice provide a valuable platform to identify the role of specific genes in hematopoiesis in vivo. Here, we describe protocols for preparation of retroviruses for overexpression or kn
Externí odkaz:
https://doaj.org/article/bfa0a5c793e9492e9070452c9d92747f
Publikováno v:
eLife, Vol 10 (2021)
Central tolerance is achieved through positive and negative selection of thymocytes mediated by T cell receptor (TCR) signaling strength. Thus, dysregulation of the thymic selection process often leads to autoimmunity. Here, we show that Capicua (CIC
Externí odkaz:
https://doaj.org/article/750cfe750b534b1f82aec2f59998e216
Autor:
Sungjun Park, Seungwon Lee, Choong-Gu Lee, Guk Yeol Park, Hyebeen Hong, Jeon-Soo Lee, Young Min Kim, Sung Bae Lee, Daehee Hwang, Youn Soo Choi, John D. Fryer, Sin-Hyeog Im, Seung-Woo Lee, Yoontae Lee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Follicular helper T (TFH) cells promote germinal centre (GC) response for efficient generation of protective antibodies during humoral immunity. Here the authors show that deficiency of the translational repressor, Capicua/CIC, enhances TFH different
Externí odkaz:
https://doaj.org/article/b60b97a6a56040e89b56ef95ec263afc
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Central tolerance is achieved through positive and negative selection of thymocytes mediated by T cell receptor (TCR) signaling strength. Thus, the dysregulation of the thymic selection process often leads to autoimmunity. Here, we show that capicua
Autor:
Hyebeen Hong, Jongeun Lee, Guk-Yeol Park, Soeun Kim, Jiho Park, Jong Seok Park, Youngkwon Song, Sujin Lee, Tae Jin Kim, You Jeong Lee, Tae-Young Roh, Seung-Ki Kwok, Sung Won Kim, Qiumin Tan, Yoontae Lee
Publikováno v:
Cell reports. 38(7)
B-1 cell development mainly occurs via fetal and neonatal hematopoiesis and is suppressed in adult bone marrow hematopoiesis. However, little is known about the factors inhibiting B-1 cell development at the adult stage. We report that capicua (CIC)
Publikováno v:
Immune Network
Capicua (CIC) is a transcriptional repressor that regulates several developmental processes. CIC deficiency results in lymphoproliferative autoimmunity accompanied by expansion of CD44hiCD62Llo effector/memory and follicular Th cell populations. Dele
Autor:
Guk Yeol Park, Sin-Hyeog Im, Youn Soo Choi, Yoontae Lee, Choong-Gu Lee, Daehee Hwang, Sung Bae Lee, Hyebeen Hong, Seung-Woo Lee, Young-Min Kim, John D. Fryer, Sungjun Park, Jeon Soo Lee, Seung Won Lee
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
NATURE COMMUNICATIONS(8)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
NATURE COMMUNICATIONS(8)
High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (TFH) cells can induce the GC response to self-antigens, subsequently leading to autoim