Výsledky vyhledávání - "HyeJin Julia Kong"

Akademický článek

Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor.

Autor: Elena Topchiy, Mihai Cirstea, HyeJin Julia Kong, John H Boyd, Yingjin Wang, James A Russell, Keith R Walley

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155030 (2016)

Sepsis is the leading cause of death in critically ill patients. While decreased Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) function improves clinical outcomes in murine and human sepsis, the mechanisms involved have not been fully elucida

Externí odkaz: https://doaj.org/article/c20c00e208864f0b8ab4f31cb6e6ea23

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Modulation of vascular endothelial inflammatory response by proprotein convertase subtilisin-kexin type 9

Autor: Alex K.K. Leung, Yuan Chao Xue, Antyrah de Guzman, Guilherme Grzelkovski, HyeJin Julia Kong, Kelly R. Genga, James A. Russell, John H. Boyd, Gordon A. Francis, Keith R. Walley

Publikováno v: Atherosclerosis. 362:29-37

Endotoxins carried within LDL are cleared from the circulation via hepatic LDL receptor (LDLR)-mediated endocytosis. Proprotein convertase subtilisin-kexin type 9 (PCSK9) reduces this clearance by down-regulating LDLR density on hepatocytes. In addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc0b1d1b045cb44980cb2465dc25129
https://doi.org/10.1016/j.atherosclerosis.2022.09.008

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Cholesteryl Ester Transfer Protein Influences High-Density Lipoprotein Levels and Survival in Sepsis

Autor: Lisanne L. Blauw, Liam R. Brunham, HyeJin Julia Kong, Yanan Wang, John H. Boyd, James A. Russell, Mihai Cirstea, Cody Lo, Kelly R. Genga, Patrick C.N. Rensen, Keith R. Walley, Xuan Li, Mark Trinder

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 199(7), 854-862. AMER THORACIC SOC

Rationale: High-density lipoprotein (HDL) cholesterol (HDL-C) levels decline during sepsis, and lower levels are associated with worse survival. However, the genetic mechanisms underlying changes in HDL-C during sepsis, and whether the relationship w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee66358a3246e18bd48449f9e47f627
https://doi.org/10.1164/rccm.201806-1157oc

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Inhibition of Cholesteryl Ester Transfer Protein Preserves High-Density Lipoprotein Cholesterol and Improves Survival in Sepsis

Autor: Lubos Bohunek, Keith R. Walley, Liam R. Brunham, John H. Boyd, Brendan A. Daisely, Mark Trinder, Mark M. Wurfel, Christian M. Madsen, James A. Russell, Lisanne L. Blauw, Anne Tybjærg-Hansen, Patrick C.N. Rensen, Yanan Wang, Børge G. Nordestgaard, Tatjana Ponomarev, HyeJin Julia Kong

Publikováno v: Circulation, 143(9), 921-934. LIPPINCOTT WILLIAMS & WILKINS

Background: The high-density lipoprotein hypothesis of atherosclerosis has been challenged by clinical trials of cholesteryl ester transfer protein (CETP) inhibitors, which failed to show significant reductions in cardiovascular events. Plasma levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8403e40d2972efb108c216751e6a1b9
https://hdl.handle.net/1887/3563475

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Is Heparin-Binding Protein Inhibition a Mechanism of Albumin’s Efficacy in Human Septic Shock?

Autor: Jane Fisher, James A. Russell, Keith R. Walley, HyeJin Julia Kong, Adam Linder, John H. Boyd, Terry Lee, Peter Bentzer

Publikováno v: Critical Care Medicine. 46:e364-e374

Objectives: Our objectives were to determine first whether albumin prevents heparin-binding protein-induced increased endothelial cell permeability and renal cell inflammation and second, whether a plasma heparin-binding protein-to-albumin ratio pred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46dab450d48043a0f113f9c147bada63
https://doi.org/10.1097/ccm.0000000000002996

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Very Low Density Lipoprotein Receptor Sequesters Lipopolysaccharide Into Adipose Tissue During Sepsis

Autor: Elena Topchiy, Hiroyuki Hirasawa, Tadanaga Shimada, Alex K. K. Leung, James A. Russell, Keith R. Walley, Shigeto Oda, Taka-aki Nakada, Kelly R. Genga, HyeJin Julia Kong, John H. Boyd

Publikováno v: Critical care medicine. 48(1)

Obese patients have lower sepsis mortality termed the "obesity paradox." We hypothesized that lipopolysaccharide, known to be carried within lipoproteins such as very low density lipoprotein, could be sequestered in adipose tissue during sepsis; pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e9151cf5b432b163a0a7990d2df085f
https://pubmed.ncbi.nlm.nih.gov/31651422

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Low Low-Density Lipoprotein Levels Are Associated With, But Do Not Causally Contribute to, Increased Mortality in Sepsis

Autor: Keith R. Walley, John H. Boyd, James A. Russell, HyeJin Julia Kong

Publikováno v: Critical care medicine. 47(3)

OBJECTIVES Low low-density lipoprotein levels are associated with increased mortality in sepsis. Whether low low-density lipoprotein levels contribute causally to adverse sepsis outcome is unknown. DESIGN Retrospective analysis of two sepsis patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0518df1f98ee91ac431ee6ce8c502859
https://pubmed.ncbi.nlm.nih.gov/30768512

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