Výsledky vyhledávání - "Hye-Young Nam"

Data from Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis

Autor: Sunil Sudarshan, Sooryanarayana Varambally, Carolina B. Livi, Pooja Ghatalia, Gurudatta Naik, Guru Sonpavde, Eun-Young Kho, Sandeep Shelar, Anirban Kundu, Darshan S. Chandrashekar, Hye-Young Nam

The Cancer Genome Atlas (TCGA) and other large-scale genomic data pipelines have been integral to the current understanding of the molecular events underlying renal cell carcinoma (RCC). These data networks have focused mostly on primary RCC, which o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ae48cdf8a8e0c115652d3950ce3ad63
https://doi.org/10.1158/1541-7786.c.6541141

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Supplemental Figures 1-7 from Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis

1S: Principal component analysis (PCA) of the 44 experimental samples analyzed by array. S2. 2S: TCGA validation of up-regulated RCC associated genes. S3. TCGA validation of down-regulated RCC associated genes. Boxplots show expression level of each

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https://doi.org/10.1158/1541-7786.22515622

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Peri‐graft porcine‐specific CD4 + FoxP3 + regulatory T cells by CD40‐CD154 blockade prevented the rejection of porcine islet graft in diabetic mice

Autor: Hyun Je Kim, Il Hee Yoon, Yong-Hee Kim, Jun Seop Shin, Hye Young Nam, Chung Gyu Park, Hyunwoo Chung

Publikováno v: Xenotransplantation. 26

Background Anti-CD154 monoclonal antibody (mAb) treatment has been known to have potential to induce immune tolerance in organ transplantation. Several studies have suggested the involvement of CD4+ regulatory T cells (Treg s) in xeno-immune toleranc

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https://doi.org/10.1111/xen.12533

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Porcine antigen-specific IFN-γ ELISpot as a potentially valuable tool for monitoring cellular immune responses in pig-to-non-human primate islet xenotransplantation

Autor: Hye Young Nam, Yong-Hee Kim, Jun Seop Shin, Hyun Je Kim, Chung Gyu Park, Jong Min Kim, Byoung Hoon Min, Jung Sik Kim, Il Hee Yoon, Won Woo Lee

Publikováno v: Xenotransplantation. 23:310-319

Background Recent progress in xenotransplantation of porcine islets to non-human primates (NHPs) gives hope for human clinical trials in the near future. Thus, implementation of an appropriate monitoring method to detect the development of detrimenta

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https://doi.org/10.1111/xen.12248

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Mussel-inspired poly(L-DOPA)-templated mineralization for calcium phosphate-assembled intracellular nanocarriers

Autor: Hye Young Nam, Hong Jae Lee, Da Eun Kim, Jeong Ryul Choi, Sang Cheon Lee, Kyung Hyun Min

Publikováno v: Colloids and surfaces. B, Biointerfaces. 157

We developed a calcium phosphate (CaP)-assembled polymer nanocarrier for intracellular doxorubicin (DOX) delivery based on a mussel-inspired mineralization approach. A DOX-loaded core-shell polymer nanoparticle (DOX-NP) consisting of a poly(3,4-dihyd

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https://pubmed.ncbi.nlm.nih.gov/28599182

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Mitochondrial DNA copy number augments performance of A1C and oral glucose tolerance testing in the prediction of type 2 diabetes

Autor: Seong Beom Cho, Jae-Pil Jeon, Hong Kyu Lee, Hye-Young Nam, InSong Koh, Bok-Ghee Han

Publikováno v: Scientific Reports

Here, we tested the performance of the mitochondrial DNA copy number (mtDNA-CN) in predicting future type 2 diabetes (n = 1108). We used the baseline clinical data (age, sex, body mass index, waist-to-hip ratio, systolic and diastolic blood pressure)

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Network signatures of cellular immortalization in human lymphoblastoid cell lines

Autor: Sung-Mi Shim, Jun-Woo Kim, Hye Ryun Kim, Hye-Young Nam, Mee-Hee Lee, Jae-Pil Jeon, So-Young Jung, Bok-Ghee Han

Publikováno v: Biochemical and Biophysical Research Communications. 441:438-446

Highlights: •We identified network signatures of LCL immortalization from transcriptomic profiles. •More than 41% of DEGs are possibly regulated by miRNAs in LCLs. •MicroRNA target genes in LCLs are involved in apoptosis and immune-related func

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https://doi.org/10.1016/j.bbrc.2013.10.081

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Human transcriptome analysis of acute responses to glucose ingestion reveals the role of leukocytes in hyperglycemia-induced inflammation

Autor: Hyung Jin Choi, So Young Jung, Hyo Jeong Ban, Hye Sun Yun, Hye Young Nam, Yeonjung Kim, Bok Ghee Han, Jae Pil Jeon, Eun Jung Hong, Hyun Ju Kang, Seung Eun Jung

Publikováno v: Physiological Genomics. 44:1179-1187

Glucose ingestion-induced hyperglycemia has been known to induce inflammation, which is related to the pathogenesis of diabetic complications. To examine acute gene expression responses to physiological oral glucose ingestion in human circulating leu

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https://doi.org/10.1152/physiolgenomics.00179.2011

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