Ursodeoxycholate Restores Biliary Excretion of Methotrexate in Rats with Ethinyl Estradiol Induced-Cholestasis by Restoring Canalicular Mrp2 Expression

Autor: Yun Ju Kang, Hye-Young Chi, Im-Sook Song, Min-Koo Choi, Hye Hyun Yoo, Min Ju Kim, Mihwa Kwon, Chang-Koo Shim, Young A. Choi

Publikováno v: International Journal of Molecular Sciences; Volume 19; Issue 4; Pages: 1120
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 4, p 1120 (2018)

The in vivo relevance of ursodeoxycholate (UDCA) treatment (100 mg/kg/day, per oral tid for 5 days before cholestasis induction followed by the same dosing for 5 days) on hepatic function was investigated in rats with 17α-ethinylestradiol (EE, 10 mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b591c83730a14fb2aa887e3dbc8fed53
https://doi.org/10.3390/ijms19041120