Dual and Opposing Functions of the Central Amygdala in the Modulation of Pain

Autor: Torri D. Wilson, Spring Valdivia, Aleisha Khan, Hye-Sook Ahn, Anisha P. Adke, Santiago Martinez Gonzalez, Yae K. Sugimura, Yarimar Carrasquillo

Publikováno v: Cell Reports, Vol 29, Iss 2, Pp 332-346.e5 (2019)

Summary: Pain perception is essential for survival and can be amplified or suppressed by expectations, experiences, and context. The neural mechanisms underlying bidirectional modulation of pain remain largely unknown. Here, we demonstrate that the c

Externí odkaz: https://doaj.org/article/65f15556a31d4c9385196a619c56963a

Cell-type specificity of neuronal excitability and morphology in the central amygdala

Autor: Jordan J. Becker, Spring Valdivia, Torri D. Wilson, Santiago Martinez Gonzalez, Hye-Sook Ahn, Yarimar Carrasquillo, Aleisha Khan, Anisha P. Adke, Yae K. Sugimura

Publikováno v: eNeuro

Central amygdala (CeA) neurons expressing protein kinase Cδ (PKCδ+) or somatostatin (Som+) differentially modulate diverse behaviors. The underlying features supporting cell-type-specific function in the CeA, however, remain unknown. Using whole-ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a1c23e34d83ea884007ce76f39db4a
https://doi.org/10.1101/832295

Differential effect of D623N variant and wild-type Nav1.7 sodium channels on resting potential and interspike membrane potential of dorsal root ganglion neurons

Autor: Catharina G. Faber, Hye-Sook Ahn, Stephen G. Waxman, Dmytro V. Vasylyev, Sulayman D. Dib-Hajj, Palak Shah, Mark Estacion, Ingemar S. J. Merkies, Lawrence J. Macala

Publikováno v: Brain Research, 1529, 165-177. Elsevier

Sodium channel Na(v)1.7 is preferentially expressed in dorsal root ganglion (DRG) and sympathetic ganglion neurons. Gain-of-function Na(v)1.7 mutations/variants have been identified in the painful disorders inherited erythromelalgia and small-fiber n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24759af636f5f6d5e2eb22c3b92531c0
https://doi.org/10.1016/j.brainres.2013.07.005

Gain of function NaV1.7 mutations in idiopathic small fiber neuropathy

Autor: Catharina G. Faber, Monique M. Gerrits, Els K. Vanhoutte, Xiaoyang Cheng, Mark Estacion, Ingemar S. J. Merkies, Stephen G. Waxman, Janneke G. J. Hoeijmakers, Joost P.H. Drenth, Chongyang Han, Hye Sook Ahn, Giuseppe Lauria, Jin-Sung Choi, Sulayman D. Dib-Hajj

Publikováno v: Annals of Neurology, 71, 26-39
Annals of Neurology, 71, 1, pp. 26-39
Annals of Neurology, 71(1), 26-39. John Wiley & Sons Inc.
Annals of Neurology, 71(1), 26-39. Wiley

Item does not contain fulltext OBJECTIVE: Small nerve fiber neuropathy (SFN) often occurs without apparent cause, but no systematic genetic studies have been performed in patients with idiopathic SFN (I-SFN). We sought to identify a genetic basis for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ceddb5f736d9f3c2b5790f2b39e6d4
https://doi.org/10.1002/ana.22485

A new Nav1.7 sodium channel mutation I234T in a child with severe pain

Autor: Frances V. Elmslie, Lynda Tyrrell, Hye-Sook Ahn, C. Geoffrey Woods, Antonia Clarke, James J. Cox, Stephen G. Waxman, Joost P.H. Drenth, Sulayman D. Dib-Hajj

Publikováno v: European Journal of Pain, 14, 9, pp. 944-50
European Journal of Pain, 14, 944-50

Item does not contain fulltext Dominant gain-of-function mutations that hyperpolarize activation of the Na(v)1.7 sodium channel have been linked to inherited erythromelalgia (IEM), a disorder characterized by severe pain and redness in the feet and h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107014076c1d56bf7b935fcaf600b38a
https://doi.org/10.1016/j.ejpain.2010.03.007