Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hye Sik Kong"'
Design, Synthesis and Discovery of Picomolar Selective α4β2 Nicotinic Acetylcholine Receptor Ligands
Autor:
York Tomita, Amir H. Rezvani, Corinne Wells, Milton L. Brown, Yong Liu, Venkata Mahidhar Yenugonda, Nour Al-Muhtasib, Yingxian Xiao, Susan Slade, Edward D. Levin, Kenneth J. Kellar, Thao Tran, Niaz Sahibzada, Joshua E. Johnson, Teresa Xie, Sivanesan Dakshanamurthy, Hye-Sik Kong, Mikell Paige
Publikováno v:
Journal of Medicinal Chemistry. 56:8404-8421
Developing novel and selective compounds that desensitize α4β2 nicotinic acetylcholine receptors (nAChRs) could provide new effective treatments for nicotine addiction, as well as other disorders. Here we report a new class of nAChR ligands that di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68e197192efd75b2c697b610a3c526a
https://doi.org/10.1021/jm4008455
https://doi.org/10.1021/jm4008455
Autor:
Mira Jung, Shuo Tian, Yali Kong, Milton L. Brown, Anatoly Dritschilo, Guanhua Du, Li Zhang, Hye-Sik Kong
Publikováno v:
Pharmaceutical Research. 29:3373-3383
The HDAC shuttling inhibitor, YK-4-272 functions by restricting nuclear shuttling of Class II HDACs. Pre-clinical investigations of YK-4-272 bioavailability, pharmacokinetics, in vivo toxicity and tumor growth inhibition were performed to determine i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c40cf6d76c83cefeb920a7f4ab187c1
https://doi.org/10.1007/s11095-012-0832-3
https://doi.org/10.1007/s11095-012-0832-3
Publikováno v:
Journal of Pharmacy and Pharmacology. 55:1075-1082
Prednisolone 21-sulfate sodium (PDS) was synthesized as a colon-specific pro-drug of prednisolone with the expectation that it would be stable and non-absorbable in the upper intestine and release prednisolone by the action of sulfatase once it was d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e830d4404ce8002b6fe82bdf620ae274
https://doi.org/10.1211/0022357021413
https://doi.org/10.1211/0022357021413
Autor:
Li Zhang, Junke Song, Venkata Mahidhar Yenugonda, Hye-Sik Kong, Milton L. Brown, Tian Shuo, Yali Kong, Guanhua Du, Amrita K. Cheema
Publikováno v:
Molecular Pharmaceutics
The discovery and development of small molecules that antagonize neuronal nicotinic acetylcholine receptors may provide new ligands for evaluation in models of depression or addiction. We discovered a small molecule, VMY-2-95, a nAChR ligand with pic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04dd557efd32acd9906173269fda1a0f
https://pubmed.ncbi.nlm.nih.gov/25533629
https://pubmed.ncbi.nlm.nih.gov/25533629
Autor:
Hye-Sik Kong, Hyo Jin Kang, Yong Liu, Scott Grindrod, Insoo Bae, Shujie Hou, Kan Wang, Milton L. Brown, Yali Kong, Li Zhang, Hee Jeong Kim, Yong Weon Yi
Publikováno v:
Journal of medicinal chemistry. 57(15)
The aberrant activation of STAT3 occurs in many human cancers and promotes tumor progression. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of STAT3. Synthesized carbazole derived with fluorophore compound 12 was disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db1ddae008662f06b938a097c2db569
https://pubmed.ncbi.nlm.nih.gov/24978112
https://pubmed.ncbi.nlm.nih.gov/24978112
Autor:
Hye-Sik Kong, Matthew Miessau, Mikell Paige, Kan Wang, Robert J. Snelgrove, Y. Michael Shim, Eliseu O. De Oliveira, Suhyon Kim
The leukotriene A 4 hydrolase enzyme is a dual functioning enzyme with the following two catalytic activities: an epoxide hydrolase function that transforms the lipid metabolite leukotriene A 4 to leukotriene B 4 and an aminopeptidase function that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d387b9b38ab7716bfdb4ec3a02572ab0
https://europepmc.org/articles/PMC3209762/
https://europepmc.org/articles/PMC3209762/
Autor:
Manoj K. Patel, Eliseu O. De Oliveira, Aparna Baheti, K. Graf, Linda MacArthur, Sivanesan Dakshanamurthy, Milton L. Brown, Kan Wang, Hye-Sik Kong, Mikell Paige
Publikováno v:
Bioorganicmedicinal chemistry. 19(14)
Hermitamides A and B are lipopeptides isolated from a Papau New Guinea collection of the marine cyanobacterium Lyngbya majuscula. We hypothesized that the hermitamides are ligands for the human voltage-gated sodium channel (hNa(V)) based on their str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7668f5555938d64550bbb9b795c5d22
https://pubmed.ncbi.nlm.nih.gov/21683602
https://pubmed.ncbi.nlm.nih.gov/21683602
Autor:
Hye Sik Kong, Vladimir Valera Romero, Karen Block, Len Neckers, Min-Jung Lee, Norman Goode, Cynthia Galindo, Mehdi Mollapour, Bradley Scroggins, Jane B. Trepel, Sunil Sudarshan, Campbell W. Gourlay, W. Marston Linehan, Carole Sourbier, Youfeng Yang
Publikováno v:
Molecular and cellular biology. 29(15)
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an inherited cancer syndrome linked to biallelic inactivation of the gene encoding the tricarboxylic acid cycle enzyme fumarate hydratase (FH). Individuals with HLRCC are at risk to develop c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538547899e46390ddaf62fbfc60da1bf
https://pubmed.ncbi.nlm.nih.gov/19470762
https://pubmed.ncbi.nlm.nih.gov/19470762
Autor:
In Ho Kim, Hye Sik Kong, Heejung Kim, Bo Im Choi, Young Mi Kim, Young-Soo Kim, Young Wook Yang, Yun Jin Jung
Publikováno v:
Drug development and industrial pharmacy. 32(3)
We synthesized dexamethasone 21-sulfate sodium (DS) as a colon-specific prodrug of dexamethasone and investigated its properties. Introduction of a sulfate group to dexamethasone lowered the apparent partition coefficient from 52.5 to 0.27 in 1-octan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9443444f011258a149173c9d6f95590
https://pubmed.ncbi.nlm.nih.gov/16556543
https://pubmed.ncbi.nlm.nih.gov/16556543
Autor:
Eun Joo, Chung, Sunmin, Lee, Edward A, Sausville, Qin, Ryan, Judith E, Karp, Ivana, Gojo, William G, Telford, Min-Jung, Lee, Hye Sik, Kong, Jane B, Trepel
Publikováno v:
Annals of clinical and laboratory science. 35(4)
Histone deacetylase (HDAC) inhibitors are a promising new class of anticancer drug. The aim of this study was to develop a versatile and sensitive technique for the pharmacodynamic (PD) assessment of HDAC inhibitor activity as monotherapy and in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::898f21bfcb9611aed524c4b6a10c90ef
https://pubmed.ncbi.nlm.nih.gov/16254255
https://pubmed.ncbi.nlm.nih.gov/16254255