Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Hye‐Youn Kim"'
Autor:
Jinsei Jung, Sun Young Joo, Hyehyun Min, Jae Won Roh, Kyung Ah Kim, Ji-Hyun Ma, John Hoon Rim, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Young Ik Koh, Hye-Youn Kim, Ho Lee, Byoung Choul Kim, Heon Yung Gee, Jinwoong Bok, Jae Young Choi, Je Kyung Seong
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 11, Pp 2423-2435 (2024)
Abstract Myh1 is a mouse deafness gene with an unknown function in the auditory system. Hearing loss in Myh1-knockout mice is characterized by an elevated threshold for the auditory brainstem response and the absence of a threshold for distortion pro
Externí odkaz:
https://doaj.org/article/c8867c2bc8f2426cbb34d60e09e8b79f
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Distant metastasis is a significant hallmark affecting to the high death rate of patients with triple-negative breast cancer (TNBC). Thus, it is crucial to identify and develop new therapeutic strategies to hinder cancer metastasis. While em
Externí odkaz:
https://doaj.org/article/1bbd9316b7a14ce5ad6fa77093c023cb
Autor:
Young‐Mi Kim, Hye‐Youn Kim, Huyen Trang Ha Thi, Jooyoung Kim, Young Jae Lee, Seong‐Jin Kim, Suntaek Hong
Publikováno v:
Molecular Oncology, Vol 17, Iss 11, Pp 2380-2395 (2023)
The incidence of colitis‐associated colorectal cancer (CAC) has increased due to a high‐nutrient diet, increased environmental stimuli and inherited gene mutations. To adequately treat CAC, drugs should be developed by identifying novel therapeut
Externí odkaz:
https://doaj.org/article/9932189c5f784a71bc7f8686112014bc
Autor:
Dong Yun Kim, Yu Jin Sub, Hye-Youn Kim, Kyeong Jee Cho, Won Il Choi, Yo Jun Choi, Min Goo Lee, Friedhelm Hildebrandt, Heon Yung Gee
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background LRRC6 is an assembly factor for dynein arms in the cytoplasm of motile ciliated cells, and when mutated, dynein arm components remained in the cytoplasm. Here, we demonstrate the role of LRRC6 in the active nuclear translocation o
Externí odkaz:
https://doaj.org/article/12d278c2f9ae4adf8b677f55832bb75b
Autor:
Kyung Seok Oh, Jae Won Roh, Sun Young Joo, Kunhi Ryu, Jung Ah Kim, Se Jin Kim, Seung Hyun Jang, Young Ik Koh, Da Hye Kim, Hye-Youn Kim, Murim Choi, Jinsei Jung, Wan Namkung, Joo Hyun Nam, Jae Young Choi, Heon Yung Gee
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 4, Pp 844-859 (2023)
Abstract Pathogenic variants of KCNQ4 cause symmetrical, late-onset, progressive, high-frequency-affected hearing loss, which eventually involves all frequencies with age. To understand the contribution of KCNQ4 variants to hearing loss, we analyzed
Externí odkaz:
https://doaj.org/article/703f8133399a488b88c67aab5d9e1a50
Publikováno v:
Molecules, Vol 29, Iss 7, p 1489 (2024)
Irritable bowel syndrome (IBS), a common gastrointestinal disorder worldwide, is characterized by chronic abdominal pain, bloating, and disordered defecation. IBS is associated with several factors, including visceral hypersensitivity, gut motility,
Externí odkaz:
https://doaj.org/article/dbf80e108c4f4df090d085a7b7969164
Publikováno v:
Organoid, Vol 3 (2023)
Since the first publication on generating kidney-like cell aggregates from pluripotent stem cells, various modifications have been made to develop more complex and detailed kidney structures. In contrast to earlier models that featured nephron-like s
Externí odkaz:
https://doaj.org/article/049748d3ed774a69afc7215e4bb7a20d
Publikováno v:
Molecules, Vol 28, Iss 24, p 8099 (2023)
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is a complex gastrointestinal disorder with a multifactorial etiology, including environmental triggers, autoimmune mechanisms, and genetic predisposition. Despite
Externí odkaz:
https://doaj.org/article/d00db65a0f02491c9d6b90317a029947
Autor:
Seyoung Yu, Yo Jun Choi, John Hoon Rim, Hye-Youn Kim, Nasim Bekheirnia, Sarah Jane Swartz, Hongzheng Dai, Shen Linda Gu, Soyeon Lee, Ryuichi Nishinakamura, Friedhelm Hildebrandt, Mir Reza Bekheirnia, Heon Yung Gee
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionMutations in ADAMTS9 cause nephronophthisis-related ciliopathies (NPHP-RC), which are characterized by multiple developmental defects and kidney diseases. Patients with NPHP-RC usually have normal glomeruli and negligible or no proteinuri
Externí odkaz:
https://doaj.org/article/5de8dedbad1248e986b831e845332ea0
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-12 (2021)
Abstract DNAJB9, a member of the heat shock protein 40 family, acts as a multifunctional player involved in the maintenance of their client proteins and cellular homeostasis. However, the mechanistic action of DNAJB9 in human malignancies is yet to b
Externí odkaz:
https://doaj.org/article/873f5f16913d4a7ba56b7cf61aad711d