New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) - The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations

Autor: Isabelle Fourel, Julie Andru, Etienne Benoit, Stéphane Besse, Benjamin Matagrin, Adrien Montagut-Romans, Virginie Lattard, Ahmed Hodroge

Publikováno v: FEBS Open Bio
FEBS Open Bio, Wiley Open Access/Elsevier, 2013, 3 (1), pp.144-150. ⟨10.1016/j.fob.2013.02.001⟩
FEBS Open Bio (3), 144-150. (2013)

The systematic use of antivitamin K anticoagulants (AVK) as rodenticides caused the selection of rats resistant to AVKs. The resistance is mainly associated to genetic polymorphisms in the Vkorc1 gene encoding the VKORC1 enzyme responsible for the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92d6c2be10262da3aa791e87eaba621
https://hal.archives-ouvertes.fr/hal-02481627

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