Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Hydroxyglutarate"'
Autor:
Leomar Y. Ballester, Guangrong Lu, Soheil Zorofchian, Venkatrao Vantaku, Vasanta Putluri, Yuanqing Yan, Octavio Arevalo, Ping Zhu, Roy F. Riascos, Arun Sreekumar, Yoshua Esquenazi, Nagireddy Putluri, Jay-Jiguang Zhu
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-10 (2018)
Abstract Cancer cells have altered cellular metabolism. Mutations in genes associated with key metabolic pathways (e.g., isocitrate dehydrogenase 1 and 2, IDH1/IDH2) are important drivers of cancer, including central nervous system (CNS) tumors. Ther
Externí odkaz:
https://doaj.org/article/a7f65a52f3034732b1f065a3ab16d1ce
Akademický článek
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Altered metabolism is a common feature of many cancers and in some cases is a consequence of mutation in metabolic genes, such as the ones involved in Krebs cycle. Isocitrate dehydrogenase (IDH) gene is mutated in many gliomas and other cancers. Phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766f5733afbd0a8338ace685968809d1
https://doi.org/10.20944/preprints202304.0478.v1
https://doi.org/10.20944/preprints202304.0478.v1
Autor:
Nadine Fabienne Voelxen, Stefan eWalenta, Martin eProescholdt, Katja eDettmer, Stefan ePusch, Wolfgang eMueller-Klieser
Publikováno v:
Frontiers in Oncology, Vol 6 (2016)
AbstractPatients with malignant gliomas have a poor prognosis with average survival of less than one year. Whereas in other tumor entities the characteristics of tumor metabolism are successfully used for therapeutic approaches, such developments are
Externí odkaz:
https://doaj.org/article/107c48ca0bf44017976f30c828ce61fd
Autor:
Jeffrey R. Idle, Diren Beyoğlu
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2900, p 2900 (2021)
Cancers, Vol 13, Iss 2900, p 2900 (2021)
Simple Summary Oncometabolites are produced by cancer cells and assist the cancer to proliferate and progress. Oncometabolites occur as a result of mutated enzymes in the tumor tissue or due to hypoxia. These processes result in either the abnormal b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb81db04a5700dcffe1b576785fb1407
https://pubmed.ncbi.nlm.nih.gov/34200553
https://pubmed.ncbi.nlm.nih.gov/34200553
Publikováno v:
The Febs Journal
Electron‐transferring flavoproteins (ETFs) have been found in all kingdoms of life, mostly assisting in shuttling electrons to the respiratory chain for ATP production. While the human (h) ETF has been studied in great detail, very little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a00becb0613298f8aadeffc3b6e90e9
http://europepmc.org/articles/PMC6771786
http://europepmc.org/articles/PMC6771786
Autor:
Hannah Marie Brown, Rong Chen, R Cooks, Mark E. Jentoft, Erik H. Middlebrooks, Kaisorn L. Chaichana, Diogo P. Garcia, Alfredo Quiñones-Hinojosa
Publikováno v:
American Journal of Clinical Pathology. 156:S141-S142
Introduction/Objective Maximizing surgical resection in gliomas, while avoiding compromising non-infiltrated tissue, is associated with survival benefit. Current methodologies are suboptimal in providing rapid, intraoperative molecular characterizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5b18d8db02a9a04db6f50f839c2637e
https://doi.org/10.1093/ajcp/aqab191.302
https://doi.org/10.1093/ajcp/aqab191.302
Akademický článek
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Akademický článek
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Autor:
Ugele, Ines, Cardenas-Conejo, Zugey Elizabeth, Hammon, Kathrin, Wehrstein, Monika, Bruss, Christina, Peter, Katrin, Singer, Katrin, Gottfried, Eva, Boesch, Jakob, Oefner, Peter J., Dettmer, Katja, Renner, Kathrin, Kreutz, Marina
Publikováno v:
International Journal of Molecular Sciences
Volume 20
Issue 3
International Journal of Molecular Sciences, Vol 20, Iss 3, p 742 (2019)
Volume 20
Issue 3
International Journal of Molecular Sciences, Vol 20, Iss 3, p 742 (2019)
Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb7149a7702551350426377f1a4ebe0e