A Larger Membrane Area Increases Cytokine Removal in Polymethyl Methacrylate Hemofilters

Autor: Tomoyuki Nakamura, Kazuhiro Moriyama, Naohide Kuriyama, Yoshitaka Hara, Satoshi Komatsu, Takahiro Kawaji, Yu Kato, Takuma Ishihara, Ayumi Shintani, Osamu Nishida

Publikováno v: Membranes, Vol 12, Iss 8, p 811 (2022)

Blood purification is performed to control cytokines in critically ill patients. The relationship between the clearance (CL) and the membrane area during adsorption is not clear. We hypothesized that the CL increases with the hydrophobic area when hy

Externí odkaz: https://doaj.org/article/2bfc9db9246a42dc9a7f213453761fea

Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels

Autor: Kenny M. Van Theemsche, Dieter V. Van de Sande, Dirk J. Snyders, Alain J. Labro

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

In the Nav channel family the lipophilic drugs/toxins binding sites and the presence of fenestrations in the channel pore wall are well defined and categorized. No such classification exists in the much larger Kv channel family, although certain lipo

Externí odkaz: https://doaj.org/article/a94ce2e0b6234c8fa8f2c91c3dcb1cc6

Hydrophobic binding peptide-conjugated hybrid lipid-mesoporous silica nanoparticles for effective chemo-photothermal therapy of pancreatic cancer

Autor: Raj Kumar Thapa, Hanh Thuy Nguyen, Milan Gautam, Aarajana Shrestha, Eung Seok Lee, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim

Publikováno v: Drug Delivery, Vol 24, Iss 1, Pp 1690-1702 (2017)

Nanoparticle-based drug delivery systems are designed to reach tumor sites based on their enhanced permeation and retention effects. However, a lack of interaction of these nanoparticles with cancer cells might lead to reduced uptake in the tumors, w

Externí odkaz: https://doaj.org/article/46c0b7291cfd4f9c942b7bafdff42fca

Utilization Phase Transition Component Method to Prepare Specially Functionalized Nanoemulsion by Adding Resveratrol/Phenethyl Resorcinol Mixed Active Components and Application in Free Radicals Removal

Autor: Cui Songzhu, Jianhua Ji, Tao Wu, Wenwen Liu, Dejun Sun

Publikováno v: Journal of Nanoscience and Nanotechnology. 20:7769-7774

To explore the possibility of using a specially functionalized nanoemulsion for the removal of free radical, resveratrol and phenethyl resorcinol were employed to form resveratrol/phenethyl resorcinol mixed active components, and the removal efficien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::486d2ed021e21065a1cf88beb6437ccd
https://doi.org/10.1166/jnn.2020.18607

Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes

Autor: Charoutioun S. Bodourian, Nirmal Poudel, Anastassios C. Papageorgiou, Mariana Antoniadi, Nikolaos D. Georgakis, Hiroshi Abe, Nikolaos E. Labrou

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3606
International journal of molecular sciences 23(7), 3606 (2022). doi:10.3390/ijms23073606

Glutathione transferases (GSTs; EC 2.5.1.18) form a group of multifunctional enzymes that are involved in phase II of the cellular detoxification mechanism and are associated with increased susceptibility to cancer development and resistance to antic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0057ae0bafbb7f689e7db30ff2efc7c6
https://pubmed.ncbi.nlm.nih.gov/35408962