p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

Autor: Syed Zahid Ali Shah, Deming Zhao, Tariq Hussain, Naveed Sabir, Mazhar Hussain Mangi, Lifeng Yang

Publikováno v: Frontiers in Molecular Neuroscience, Vol 11 (2018)

Prion diseases are a group of fatal and debilitating neurodegenerative diseases affecting humans and animal species. The conversion of a non-pathogenic normal cellular protein (PrPc) into an abnormal infectious, protease-resistant, pathogenic form pr

Externí odkaz: https://doaj.org/article/0828be784f89453783ffb58a3ffd0e38

p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases

Autor: Deming Zhao, Tariq Hussain, Syed Zahid Ali Shah, Lifeng Yang, Mazhar Hussain Mangi, Naveed Sabir

Publikováno v: Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 11 (2018)

Prion diseases are a group of fatal and debilitating neurodegenerative diseases affecting humans and animal species. The conversion of a non-pathogenic normal cellular protein (PrPc) into an abnormal infectious, protease-resistant, pathogenic form pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c721f090da263c7f43a3fd0798dae4a
http://europepmc.org/articles/PMC6180192

Efeito da ativação enzimática de um gel clareador sobre a cinética de degradação do peróxido de hidrogênio, eficácia clareadora, difusão e citotoxicidade trans-amelodentinária

Autor: Ortecho Zuta, Uxua

Orientador: Diana Gabriela de Sousa Soares
No presente estudo, a enzima horseradish peroxidase (HRP) foi empregada como agente catalizador de um gel contendo 35% de peróxido de hidrogênio (H2O2), objetivando a aceleração da sua taxa de decom

Externí odkaz: http://hdl.handle.net/11449/151486

Increased Oxidative Stress Response in Granulocytes from Older Patients with a Hip Fracture May Account for Slow Regeneration

Autor: Christoph Ihle, Zhiyong Wang, Guobin Wang, Andreas K. Nussler, Rainer Burgkart, Natascha C. Nüssler, Karl F. Braun, Lilianna Schyschka, Florian Gebhard, Martijn van Griensven, Ulrich Stöckle, Stefan Pscherer, Helen Vester, Sabrina Ehnert

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2014 (2014)
Oxidative Medicine and Cellular Longevity, 2014. Hindawi Publishing Corporation

Proximal femur fracture, a typical fracture of the elderly, is often associated with morbidity, reduced quality of life, impaired physical function and increased mortality. There exists evidence that responses of the hematopoietic microenvironment to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cff8470c339015ea769329d72ab50b

Susceptibility of lung epithelial cells to alkylating genotoxic insult

Autor: Róza Ádány, Károly Nagy, Sándor Szucs, Balázs Ádám

Publikováno v: Nagy, K, Ádány, R, Szűcs, S & Ádám, B 2013, ' Susceptibility of lung epithelial cells to alkylating genotoxic insult ', Environmental and Molecular Mutagenesis, vol. 54, no. 8, pp. 682-689 . https://doi.org/10.1002/em.21800

Alkylation is one of the most common types of DNA damage that can lead to mutations and cancer. Lung is the primary target organ of airborne alkylators such as ethylene oxide (EO). However, the ability of EO to cause lung cancer has not been clearly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcc441955bc3c24386844257b7b89f1
https://doi.org/10.1016/j.toxlet.2014.06.290