Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers

Autor: Yaqing Chen, Erik Misselwitz, Asger Holm Agergaard, Amanda Andersen, Carsten Pedersen, Henrik Birkedal

Publikováno v: Chen, Y, Misselwitz, E, Agergaard, A H, Andersen, A, Pedersen, C & Birkedal, H 2022, ' Self-forming double-crosslinked hydrogels by the marriage of catechols and enzyme mimetic polymers ', Chemical communications (Cambridge, England), vol. 58, no. 45, pp. 6526-6529 . https://doi.org/10.1039/d2cc01290a

Self-forming double-crosslinked (DC) hydrogels were designed by incorporating enzyme-mimicking metal coordination polymer crosslinks and catechol chemistry. A macromolecular tris-histidine copper complex acted both as part of the hydrogel network and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bd35155db68c25078f5e6b256eb1ee
https://doi.org/10.1039/d2cc01290a

Viscoelastic Chondroitin Sulfate and Hyaluronic Acid Double-Network Hydrogels with Reversible Cross-Links

Autor: Mihajlovic, Marko, Rikkers, Margot, Mihajlovic, Milos, Viola, Martina, Schuiringa, Gerke, Ilochonwu, Blessing C., Masereeuw, Rosalinde, Vonk, Lucienne, Malda, Jos, Ito, Keita, Vermonden, Tina, Pharmaceutics, Pharmacology, Afd Pharmaceutics, Afd Pharmacology, Equine Musculoskeletal Biology, dES RMSC

Publikováno v: Biomacromolecules, 23(3), 1350. American Chemical Society : Division of Carbohydrate Chemistry
Biomacromolecules, 23(3), 1350-1365. American Chemical Society

Viscoelastic hydrogels are gaining interest as they possess necessary requirements for bioprinting and injectability. By means of reversible, dynamic covalent bonds, it is possible to achieve features that recapitulate the dynamic character of the ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c7729c0ecf894c8bf45137f12bbbb4b
https://dspace.library.uu.nl/handle/1874/424724

Oxygen-distribution within 3-D collagen I hydrogels for bone tissue engineering

Autor: Elizabeth R. Balmayor, Laura Heimann, Martin S. Gutbrod, Martijn van Griensven, Robert J. Meier, Gregor Liebsch, Paul Wolff

Publikováno v: Materials Science & Engineering C-Materials for Biological Applications, 95, 422-427. Elsevier Science

Tissue engineering (TE) approaches typically envisage the structural and functional reconstitution of previously damaged tissue in situ. An adequate three-dimensional environment is therefore of fundamental importance for the designated cells associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fafb8adb400f2fbedc36528b010d39
https://doi.org/10.1016/j.msec.2018.02.015

Conjugated protein domains as engineered scaffold proteins

Autor: Lenne J M Lemmens, Luc Brunsveld, Christian Ottmann

Publikováno v: Bioconjugate Chemistry, 31(6), 1596-1603. American Chemical Society
Bioconjugate Chemistry

Assembly of proteins into higher-order complexes generates specificity and selectivity in cellular signaling. Signaling complex formation is facilitated by scaffold proteins that use modular scaffolding domains, which recruit specific pathway enzymes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d037a8768e0e02dfdd069886503f88
https://research.tue.nl/nl/publications/25d6b3c7-a88f-4ad1-8e37-ecd1bfdc42a7

Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications

Autor: Ebbesen, Morten Frendø, Kaspersen, Liselotte, Hansen, Irene M, Thomsen, Troels Kragsig, Bienk, Konrad, Cai, Yunpeng, Malle, Birgitte Mølholm, Howard, Kenneth Alan

Publikováno v: Ebbesen, M F, Ebbesen, M F, Kaspersen, L, Hansen, I M, Thomsen, T K, Bienk, K, Cai, Y, Malle, B M & Howard, K A 2017, ' Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications. ', Molecular Pharmaceutics, vol. 14, no. 7, pp. 2359-2367 . https://doi.org/10.1021/acs.molpharmaceut.7b00236
Hansen, I, Ebbesen, M F, Kaspersen, L, Thomsen, T B, Bienk, K, Cai, Y, Malle, B M & Howard, K 2017, ' Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications ', Molecular Pharmaceutics, vol. 14, no. 7, pp. 2359–2367 . https://doi.org/10.1021/acs.molpharmaceut.7b00236

This study investigates the effects of different molecular weight hyaluronic acids (HAs) on the mucosal nanostructure using a pig stomach mucin hydrogel as a mucosal barrier model. Microparticles (1.0 μm) and nanoparticles (200 nm) were used as prob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331021d356aa2be8cd9a3637ee9555bd
https://doi.org/10.1021/acs.molpharmaceut.7b00236