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Chemical Evaluation of the Effects of Storage Conditions on the Botanical Goldenseal using Marker-based and Metabolomics Approaches

Autor: Khin, Manead, Cech, Nadja B., Kellogg, Joshua J., Caesar, Lindsay K.

Publikováno v: The Yale Journal of Biology and Medicine

Hydrastis canadensis, commonly known as goldenseal, is a botanical native to the southeastern United States that has been used for the treatment of infection. The activity of goldenseal is often attributed to the presence of alkaloids (cyclic, nitrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3b912d2270b645af2aefebf18c8ba21
http://europepmc.org/articles/PMC7309669

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Studies on asymmetric total synthesis of (−)-β-hydrastine via a chiral epoxide ring-opening cascade cyclization strategy

Autor: Yongxiang Liu, Tianxiao Wu, Xinjing Song, Jiaxin Meng, Qiaohua Qin, Maosheng Cheng, Yang Zheng, Dongmei Zhao, Jihui Li

Publikováno v: RSC Advances. 10:18953-18958

Herein, facile and enantioselective approaches to synthesize the core phthalide tetrahydroisoquinoline scaffold of (−)-β-hydrastine via both a CF3COOH-catalyzed (86% ee) and KHMDS-catalyzed (78% ee) epoxide ring-opening/transesterification cascade

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9605e0f74b7cbbecba72529c087d77a3
https://doi.org/10.1039/d0ra03038d

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Total Synthesis of (±)-Setigerumine I: Biosynthetic Origins of the Elusive Racemic Papaveracaea Isoxazolidine Alkaloids

Autor: László Kürti, Juha H. Siitonen, Ana Victoria Serna

Publikováno v: Angew Chem Int Ed Engl

The biosynthetic origins of the structurally related racemic isoxazolidine Papaveraceae alkaloids Setigerumine I, Dactylicapnosinine and Dactylicapnosine have remained elusive since their original isolation over two decades ago. Herein we report the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767c0e0958700deb24264df43b086142
https://doi.org/10.33774/chemrxiv-2021-m9ltg

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Wild Goldenseal (Hydrastis canadensis) Rhizome/Root Alkaloid Content in Relation to Colony and Harvest Stage

Autor: Grady H. Zuiderveen, Eric P. Burkhart

Publikováno v: Journal of Herbs, Spices & Medicinal Plants. 25:128-140

This study examined the three major alkaloids (berberine, hydrastine, and canadine) in wild goldenseal (Hydrastis canadensis) roots and rhizomes in relation to plant colony and harvest stage. Golde...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0be3941f436cb9edf9043638b1117e1f
https://doi.org/10.1080/10496475.2019.1577322

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An Acid-Catalyzed Epoxide Ring-Opening/Transesterification Cascade Cyclization to Diastereoselective Syntheses of (±)-β-Noscapine and (±)-β-Hydrastine

Autor: Xinjing Song, Jihui Li, Dongmei Zhao, Jiaxin Meng, Maosheng Cheng, Yang Zheng, Yongxiang Liu, Tianxiao Wu, Qiaohua Qin

Publikováno v: Organic letters. 21(17)

An acid-catalyzed stereoselective epoxide ring-opening/intramolecular transesterification cascade cyclization reaction and N-Boc deprotection was found to be a successful strategy to construct the phthalide tetrahydroisoquinoline skeleton in one pot.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a1af2fe9be3adec4b5c8c21cbbb7d4
https://pubmed.ncbi.nlm.nih.gov/31449423

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Quantification of natural products in herbal supplements: a combined NMR approach applied on goldenseal

Autor: Clément Milande, Jonathan Farjon, Estelle Martineau, Phuong Mai Le, Patrick Giraudeau

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2019, 165, pp.155-161. ⟨10.1016/j.jpba.2018.11.062⟩

International audience; Authentication of natural products is of major relevance in the context of manufactured drugs or herbal supplements since such active products generate a lucrative market. The analytical method to identify and quantify valuabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3baf61df178be05f92ad4387f3b5c19
https://hal.archives-ouvertes.fr/hal-03130979/file/Manuscript-JPBA-JF-reviewed.pdf

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