Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.

Autor: Watson Levings RS; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Broome TA; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Smith AD; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Rice BL; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Gibbs EP; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Myara DA; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Hyddmark EV; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Nasri E; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Zarezadeh A; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Levings PP; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Lu Y; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., White ME; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Dacanay EA; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Foremny GB; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida., Evans CH; 3 Rehabilitation Medicine Research Center, Mayo Clinic , Rochester, Minnesota., Morton AJ; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Winter M; 4 Department of Small Animal Clinical Sciences, University of Florida , Gainesville, Florida., Dark MJ; 5 Department of Infectious Diseases and Pathology, University of Florida , Gainesville, Florida., Nickerson DM; 6 Department of Statistics and Actuarial Science, University of Central Florida , Orlando, Florida., Colahan PT; 2 Department of Large Animal Clinical Sciences, University of Florida , Gainesville, Florida., Ghivizzani SC; 1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida.

Publikováno v: Human gene therapy. Clinical development [Hum Gene Ther Clin Dev] 2018 Jun; Vol. 29 (2), pp. 90-100.