Zobrazeno 1 - 10
of 1 195
pro vyhledávání: '"Hybrid molecules"'
Autor:
Ibrahim M.Z. Fares, Nesma E. Mahmoud, Ismail A. Abdelhamid, Ahmed H.M. Elwahy, Arwa sultan Alqahtani, Nada S. Ibrahim, Mostafa E. Salem, Hadeer M. Diab
Publikováno v:
Results in Chemistry, Vol 10, Iss , Pp 101684- (2024)
Bacterial infections are a global issue, causing sickness and death, mainly in developing nations. Resistance to current medicines is a significant issue in healthcare. Overcoming the resistance problem will necessitate the development of molecules w
Externí odkaz:
https://doaj.org/article/65513ad2854c4a2dbaf41c50836d433c
Autor:
Yulia R. Aleksandrova, Natalia S. Nikolaeva, Inna A. Shagina, Karina D. Smirnova, Alla A. Zubishina, Alexander I. Khlopotinin, Artem N. Fakhrutdinov, Alexander L. Khokhlov, Roman S. Begunov, Margarita E. Neganova
Publikováno v:
Molecules, Vol 29, Iss 22, p 5360 (2024)
The era of chemotherapy began in the 1940s, which is the basis of traditional antitumor approaches and, being one of the most high-tech treatment methods, is still widely used to treat various types of cancer. A promising direction in modern medicina
Externí odkaz:
https://doaj.org/article/4e19b94b8d9540198e0285d42a8652d3
Autor:
Anna Rapacz, Marcin Jakubiec, Michał Abram, Jakub Jasiński, Karolina Chrzan, Małgorzata Góra, Anna Dziubina, Katarzyna Wójcik-Pszczoła, Paulina Koczurkiewicz-Adamczyk, Katarzyna Ciepiela, Elżbieta Pękala, Jolanta Obniska, Krzysztof Kamiński
Publikováno v:
Pharmaceuticals, Vol 17, Iss 11, p 1532 (2024)
Background/Objectives: To address the unmet clinical needs in the treatment of epilepsy and pain, the continued development of more effective and safer anticonvulsants and analgesics is still necessary. Therefore, herein we report synthesis and antis
Externí odkaz:
https://doaj.org/article/a251ba8d7a9a4016a31cb678d9a9dcad
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103119- (2024)
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the build-up of extracellular amyloid β (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). Ferroptosis, an iron (Fe)-dependent form of cell death plays a signific
Externí odkaz:
https://doaj.org/article/e2dca8e9fc66419da6c4decc71883f25
Publikováno v:
Molbank, Vol 2024, Iss 1, p M1758 (2024)
For the first time, a synthetic analogue of natural (5Z,9Z)-dienoic acid has been synthesized in the form of a hybrid molecule containing a fragment of oleanolic acid and (5Z,9Z)-tetradeca-5.9-dienedicarboxylic acid, synthesized using a new reaction
Externí odkaz:
https://doaj.org/article/88c03a5a318f456288363608d7c9d57c
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101451- (2024)
A new series of indazole-indolizine-triazine hybrid molecules was obtained by [3 + 2] cycloaddition reaction between newly synthesized nitrogen ylides with indazole skeleton and previously reported dipolarophile 2‐ethynyl‐4,6‐dimethoxy‐1,3,5
Externí odkaz:
https://doaj.org/article/d300f57c56c54066bbddb97d40ad34c2
Autor:
Venkateswarlu Banoji, Kishore Kumar Angajala, Sunitha Vianala, Subhash Manne, Koteshwar rao Ravulapelly, Jagadeshwar Vannada
Publikováno v:
Results in Chemistry, Vol 7, Iss , Pp 101294- (2024)
Hybrid molecules of pharmacophores could enhance the desired pharmacological activity while minimizing the side effects and drug resistance associated with individual pharmacophores. In this study, we synthesized twelve bis-1,2,3-triazole-based chalc
Externí odkaz:
https://doaj.org/article/1e94d21ed4524f27984a7cf02c3b6ebe
Autor:
Feike Zhao, Xueyan Sun, Jian Li, Junyuan Du, Zhiyi Wu, Shujuan Liu, Liangzhu Chen, Binghu Fang
Publikováno v:
Molecules, Vol 29, Iss 10, p 2169 (2024)
Amoxicillin and sulbactam are widely used in animal food compounding. Amoxicillin–sulbactam hybrid molecules are bicester compounds made by linking amoxicillin and sulbactam with methylene groups and have good application prospects. However, the re
Externí odkaz:
https://doaj.org/article/94cec71449c54785a5a4dc4a04afce30
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Eleven two-carbon tethered artemisinin–isatin hybrids (4a–k) were designed, synthesized, and evaluated for their antiproliferative activity against MCF-7, MDA-MB-231, and MDA-MB-231/ADR breast cancer cell lines, as well as cytotoxicity toward MCF
Externí odkaz:
https://doaj.org/article/2e9e8f18a26f48c2a1565a3f680ca1d0
Autor:
Nabil A. Alhakamy, Mohammad Saquib, Sanobar, Mohammad Faheem Khan, Waseem Ahmad Ansari, Deema O. Arif, Mohammad Irfan, Mohammad Imran Khan, Mohd Kamil Hussain
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Twelve novel neo-tanshinlactone–chalcone hybrid molecules were constructed through a versatile methodology involving the Horner–Wadsworth–Emmons (HWE) olefination of 4-formyl-2H-benzo [h]chromen-2-ones and phosphonic acid diethyl esters, as the
Externí odkaz:
https://doaj.org/article/a2ff4c9a7eca445ab5b7caec47502acd