Zobrazeno 1 - 10
of 1 256
pro vyhledávání: '"Hybrid compounds"'
Autor:
Ana Stepanović, Nataša Terzić Jovanović, Aleksandra Korać, Mario Zlatović, Igor Nikolić, Igor Opsenica, Milica Pešić
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116496- (2024)
Two novel hybrid compounds, CON1 and CON2, have been developed by combining sclareol (SC) and doxorubicin (DOX) into a single molecular entity. These hybrid compounds have a 1:1 molar ratio of covalently linked SC and DOX. They have demonstrated prom
Externí odkaz:
https://doaj.org/article/a86ffc41cb2e4d2e91515a3f00cacb5f
Autor:
Michał Abram, Marcin Jakubiec, Paulina Koczurkiewicz-Adamczyk, Agata Doroz-Płonka, Anna Rapacz, Krzysztof Kamiński
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 9861 (2024)
In our current study, we developed a focused series of original ((benzyloxy)benzyl)propanamide derivatives that demonstrated potent activity across in vivo mouse seizure models, specifically, maximal electroshock (MES) and 6 Hz (32 mA) seizures. Amon
Externí odkaz:
https://doaj.org/article/267ad09041614b4a9618339345e9330d
Autor:
Kwanele Ngece, Thabisa L. Ntondini, Vuyolwethu Khwaza, Athandwe M. Paca, Blessing A. Aderibigbe
Publikováno v:
Pharmaceutics, Vol 16, Iss 8, p 1065 (2024)
Polyenes are a class of organic compounds well known for their potent antifungal properties. They are effective due to their ability to target and disrupt fungal cell membranes by binding to ergosterol and forming pores. Despite their effectiveness a
Externí odkaz:
https://doaj.org/article/c0d23a700b894e178760a7a84e693efe
Publikováno v:
Molbank, Vol 2024, Iss 1, p M1779 (2024)
A series of 5-fluorouracil/coumarin and 5-fluorouracil/chromone hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds and all intermediates were elucidated by spectroscopic analysis. Furthe
Externí odkaz:
https://doaj.org/article/6d0dd1d67d1d4d57a89bd452ececdb54
Autor:
Marlène Huguette Tsaffo Mbognou, Stéphanie D. Lambert, Ernestine Mimba Mumbfu, Joachim Caucheteux, Antoine Farcy, Nathalie Fagel, Emmanuel Djoufac Woumfo, Julien G. Mahy
Publikováno v:
Results in Surfaces and Interfaces, Vol 14, Iss , Pp 100183- (2024)
A natural clay from Bakotcha in Cameroon was modified with two silanes, tetramethoxysilane (TMOS) and [3-(2-aminoethyl)aminopropyl]trimethoxysilane (EDAS) to increase its adsorption properties. The modified clay is intended to be used as an efficient
Externí odkaz:
https://doaj.org/article/bfbf2262994f4c919a0cf41e543fdd4e
Publikováno v:
Molecules, Vol 29, Iss 10, p 2277 (2024)
Cancer is ranked among lethal diseases globally, and the increasing number of cancer cases and deaths results from limited access to effective therapeutics. The use of plant-based medicine has been gaining interest from several researchers. Carvacrol
Externí odkaz:
https://doaj.org/article/1516f5c42ef44aeca3d4ac6ea2095fbe
Publikováno v:
Acta Poloniae Pharmaceutica, Vol 80, Iss 2, Pp 289-304 (2023)
Synthesis and biological evaluation of hybrid molecules combining naturally occurring antioxidant active structures with anti-inflammatory agents has been a strong trend in medicinal chemistry. This study focuses on modulating the structure of curcum
Externí odkaz:
https://doaj.org/article/0cd05eb874de4eaeb8e4a92051092bce
Autor:
Bayu Ardiansah, Muhammad Ridho Hardhani, Decky Duem Syaban Ridho Putera, Tuti Wukirsari, Antonius Herry Cahyana, JingWen Jia, Md. Musawwer Khan
Publikováno v:
Case Studies in Chemical and Environmental Engineering, Vol 8, Iss , Pp 100425- (2023)
Half- and full-skeletal of curcumin analogues containing mono- and bis-triazole scaffold have been successfully synthesized from simple aromatic aldehydes. The route is including aldol condensation, propargylation, and then continued with azide-alkyn
Externí odkaz:
https://doaj.org/article/4e789f7b83e54cd2a64fb2f05a041e09
Publikováno v:
Molbank, Vol 2023, Iss 4, p M1745 (2023)
A series of 5-FU-ASA hybrids were synthesized with good yields using click chemistry as the key step. The structures of these compounds were elucidated by spectroscopic analysis. Finally, an optimal pharmacokinetic profile was also estimated for each
Externí odkaz:
https://doaj.org/article/e6b922e985364b4a845dbf1a841405f6
Autor:
Alice P. Borges, Malu M. S. Obata, Silvia H. Libardi, Rafael O. Trevisan, Victor M. Deflon, Ulrich Abram, Francis B. Ferreira, Luiz Antônio S. Costa, Antonio O. T. Patrocínio, Marcos V. da Silva, Júlio C. Borges, Pedro I. S. Maia
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 452 (2024)
Leishmaniasis is a group of parasitic diseases with the potential to infect more than 1 billion people; however, its treatment is still old and inadequate. In order to contribute to changing this view, this work consisted of the development of comple
Externí odkaz:
https://doaj.org/article/ea751c10cb2546d0868d017ad900d1b8