Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hyatt Balke-Want"'
Autor:
Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G. Mancini, Gavin L. Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J. Fisher, Annie K. Brown, Ramya H. Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L. Mackall, Steven A. Feldman
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-16 (2023)
Abstract Background Chimeric Antigen Receptor (CAR) T cells are now standard of care (SOC) for some patients with B cell and plasma cell malignancies and could disrupt the therapeutic landscape of solid tumors. However, access to CAR-T cells is not a
Externí odkaz:
https://doaj.org/article/30c152e41bad4daaa1a6be153fb3bf6c
Autor:
Jan-Michel Heger, Julia Mattlener, Philipp Gödel, Hyatt Balke-Want, Noëlle Sieg, Nadine Kutsch, Richard Lewis, Fabian Ullrich, Roland F. Schwarz, Kerstin Becker, Jonathan Weiss, H. Christian Reinhardt, Michael Hallek, Peter Borchmann, Bastian von Tresckow, Sven Borchmann
Publikováno v:
HemaSphere, Vol 7, p e45690bd (2023)
Externí odkaz:
https://doaj.org/article/4da024e7441c4c5c9cdc01e980255a86
Autor:
Johannes Brägelmann, Marcel A. Dammert, Felix Dietlein, Johannes M. Heuckmann, Axel Choidas, Stefanie Böhm, André Richters, Debjit Basu, Verena Tischler, Carina Lorenz, Peter Habenberger, Zhizhou Fang, Sandra Ortiz-Cuaran, Frauke Leenders, Jan Eickhoff, Uwe Koch, Matthäus Getlik, Martin Termathe, Muhammad Sallouh, Zoltán Greff, Zoltán Varga, Hyatt Balke-Want, Christopher A. French, Martin Peifer, H. Christian Reinhardt, László Örfi, György Kéri, Sascha Ansén, Lukas C. Heukamp, Reinhard Büttner, Daniel Rauh, Bert M. Klebl, Roman K. Thomas, Martin L. Sos
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2833-2845 (2017)
Kinase inhibitors represent the backbone of targeted cancer therapy, yet only a limited number of oncogenic drivers are directly druggable. By interrogating the activity of 1,505 kinase inhibitors, we found that BRD4-NUT-rearranged NUT midline carcin
Externí odkaz:
https://doaj.org/article/65260813004b4d5e8d198b9f59d2baa6
Autor:
Roman K. Thomas, William Pao, Daniel Rauh, Christian Grütter, Christine M. Lovly, Jonathan Weiss, Martin Peifer, Mirjam Koker, Hyatt Balke-Want, Stefanie Heynck, Martin L. Sos, Michael Hölzel, Johannes M. Heuckmann
PDF file - 82K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2e6c8b154a248944e535dac62cc353
https://doi.org/10.1158/1078-0432.22443720
https://doi.org/10.1158/1078-0432.22443720
Autor:
Roman K. Thomas, William Pao, Daniel Rauh, Christian Grütter, Christine M. Lovly, Jonathan Weiss, Martin Peifer, Mirjam Koker, Hyatt Balke-Want, Stefanie Heynck, Martin L. Sos, Michael Hölzel, Johannes M. Heuckmann
PDF file - 2MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50874a5d582a03cee1c90d32a4e04274
https://doi.org/10.1158/1078-0432.22443717
https://doi.org/10.1158/1078-0432.22443717
Autor:
Roman K. Thomas, Ralf Küppers, William Pao, Lukas C. Heukamp, Christine M. Lovly, Lydia Meder, Mirjam Koker, Martin L. Sos, Martin Peifer, Florian Malchers, Hyatt Balke-Want, Johannes M. Heuckmann
PDF file - 96K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b92d24e253e6467ff91ed570a5744c
https://doi.org/10.1158/1078-0432.22451759
https://doi.org/10.1158/1078-0432.22451759
Autor:
Roman K. Thomas, Ralf Küppers, William Pao, Lukas C. Heukamp, Christine M. Lovly, Lydia Meder, Mirjam Koker, Martin L. Sos, Martin Peifer, Florian Malchers, Hyatt Balke-Want, Johannes M. Heuckmann
CCR Translation for This Article from Differential Protein Stability and ALK Inhibitor Sensitivity of EML4-ALK Fusion Variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1022e6a74cefacb39d04946dba5470
https://doi.org/10.1158/1078-0432.22451762.v1
https://doi.org/10.1158/1078-0432.22451762.v1
Autor:
Roman K. Thomas, William Pao, Daniel Rauh, Christian Grütter, Christine M. Lovly, Jonathan Weiss, Martin Peifer, Mirjam Koker, Hyatt Balke-Want, Stefanie Heynck, Martin L. Sos, Michael Hölzel, Johannes M. Heuckmann
Purpose:EML4–ALK fusions define a subset of lung cancers that can be effectively treated with anaplastic lymphoma kinase (ALK) inhibitors. Unfortunately, the duration of response is heterogeneous and acquired resistance limits their ultimate effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1882bbf1dfc8ba00f8bba2ce513880
https://doi.org/10.1158/1078-0432.c.6519930.v1
https://doi.org/10.1158/1078-0432.c.6519930.v1
Autor:
Roman K. Thomas, Ralf Küppers, William Pao, Lukas C. Heukamp, Christine M. Lovly, Lydia Meder, Mirjam Koker, Martin L. Sos, Martin Peifer, Florian Malchers, Hyatt Balke-Want, Johannes M. Heuckmann
PDF file - 151K, Supplementary Figure 1 Different EML4-ALK variants elicit similar proliferation rates Supplementary Figure 2 ALK phosphorylation levels after inhibitor treatment Supplementary Figure 3 Schematic representation of EML4-ALK variants 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a5b2f9be2d0914258f8144771071ff
https://doi.org/10.1158/1078-0432.22451756.v1
https://doi.org/10.1158/1078-0432.22451756.v1
Autor:
Roman K. Thomas, Ralf Küppers, William Pao, Lukas C. Heukamp, Christine M. Lovly, Lydia Meder, Mirjam Koker, Martin L. Sos, Martin Peifer, Florian Malchers, Hyatt Balke-Want, Johannes M. Heuckmann
Purpose:ALK rearrangement–positive lung cancers can be effectively treated with ALK inhibitors. However, the magnitude and duration of response is heterogeneous. In addition, acquired resistance limits the efficacy of ALK inhibitors, with most upfr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b437f7137035ad1ac45c6185a7b5f86e
https://doi.org/10.1158/1078-0432.c.6522281
https://doi.org/10.1158/1078-0432.c.6522281