Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Hyang Ae Lee"'
Autor:
Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 289, Iss , Pp 117489- (2025)
Echinochrome A (EchA), a marine-derived natural product, has shown promise in treating cardiovascular and inflammatory diseases due to its antioxidant and anti-inflammatory properties. However, its cardiac safety remains underexplored. In this study,
Externí odkaz:
https://doaj.org/article/1395581cc957421585441c41c182ec15
Autor:
Sungjin Min, Suran Kim, Woo-Sup Sim, Yi Sun Choi, Hyebin Joo, Jae-Hyun Park, Su-Jin Lee, Hyeok Kim, Mi Jeong Lee, Inhea Jeong, Baofang Cui, Sung-Hyun Jo, Jin-Ju Kim, Seok Beom Hong, Yeon-Jik Choi, Kiwon Ban, Yun-Gon Kim, Jang-Ung Park, Hyang-Ae Lee, Hun-Jun Park, Seung-Woo Cho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Engineered human cardiac tissues have been utilized for various biomedical applications, including drug testing, disease modeling, and regenerative medicine. However, the applications of cardiac tissues derived from human pluripotent stem ce
Externí odkaz:
https://doaj.org/article/746cf9f492104aacbfdfb8b9b17cd070
Autor:
Mi-Sun Choi, Se-Myo Park, Soojin Kim, Hyun Jegal, Hyang-Ae Lee, Hyoung-Yun Han, Seokjoo Yoon, Sang-Kyum Kim, Jung-Hwa Oh
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 280, Iss , Pp 116516- (2024)
The assessment of neurotoxicity for environmental chemicals is of utmost importance in ensuring public health and environmental safety. Multielectrode array (MEA) technology has emerged as a powerful tool for assessing disturbances in the electrophys
Externí odkaz:
https://doaj.org/article/1109831dd2084c1d9ddee85aeb091bf0
Publikováno v:
Animal Cells and Systems, Vol 27, Iss 1, Pp 83-93 (2023)
ABSTRACTCardiomyocytes derived from human pluripotent stem cells (hPSCs) can be used in various applications including disease modeling, drug safety screening, and novel cell-based cardiac therapies. Here, we report an optimized selection and maturat
Externí odkaz:
https://doaj.org/article/7f8a43b70e084a48bb598e863b7bf4d2
Autor:
Yoo Sung Kim, NaRi Seo, Ji-Hye Kim, Soyeong Kang, Ji Won Park, Ki Dae Park, Hyang-Ae Lee, Misun Park
Publikováno v:
Cells, Vol 12, Iss 24, p 2818 (2023)
The therapeutic potential of directly reprogrammed neural stem cells (iNSCs) for neurodegenerative diseases relies on reducing the innate tumorigenicity of pluripotent stem cells. However, the heterogeneity within iNSCs is a major hurdle in quality c
Externí odkaz:
https://doaj.org/article/6e899170f90848ccbb7abf045e671387
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Background: Field potential (FP) signals from human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) spheroid which are used for drug safety tests in the preclinical stage are different from action potential (AP) signals and require wor
Externí odkaz:
https://doaj.org/article/17664a0f4ad34e989b6f89c02f6d314d
Autor:
Mi-Ok Lee, Su-gi Lee, Cho-Rok Jung, Ye Seul Son, Jae-Woon Ryu, Kwang Bo Jung, Jun-Ho Ahn, Jung-Hwa Oh, Hyang-Ae Lee, Jung Hwa Lim, Janghwan Kim, Insu Jang, Jinhyuk Choi, Jaeeun Jung, Kunhyang Park, Byungwook Lee, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Quantitative methods to assess the quality of hPSC-derived organoids have not been developed. Here they present a prediction algorithm to assess the transcriptomic similarity between hPSC-derived organoids and the corresponding human target organs an
Externí odkaz:
https://doaj.org/article/27708e935ee5482783e2d1c6359a3d60
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1952 (2021)
Drug-induced cardiotoxicity reduces the success rates of drug development. Thus, the limitations of current evaluation methods must be addressed. Human cardiac organoids (hCOs) derived from induced pluripotent stem cells (hiPSCs) are useful as an adv
Externí odkaz:
https://doaj.org/article/5fd6186f3ae9407187c559dd7c0f1dde
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
The Comprehensive in vitro Proarrhythmia Assay (CiPA) project suggested the torsade metric score (TMS) which requires substantial computing resources as a useful biomarker to predict proarrhythmic risk from human ether-à-go-go–related gene (hERG)
Externí odkaz:
https://doaj.org/article/576fa38fe6a0420b8072ddc77811208b
Autor:
Seri Choi, Jiwoong Choi, Seongmin Cheon, Jihong Song, Seung-Yeon Kim, Ji-eun Kim, Dae-Hwan Nam, Gohar Manzar, Su-Man Kim, Hyung-Sik Kang, Kee K. Kim, Sang Hoon Jeong, Ju-Han Lee, Eun-Kee Park, Minseob Lee, Hyang-Ae Lee, Ki-Suk Kim, Han-Jin Park, Won Keun Oh, Chungoo Park, Chang Hyun Lee, Eun-Mi Kim
Publikováno v:
Cell Biology and Toxicology. 38:557-575
Human lung organoids (hLOs) are useful for disease modelling and drug screening. However, a lack of immune cells in hLOs limits the recapitulation of in vivo cellular physiology. Here, we generated hLOs containing alveolar macrophage (AMφ)-like cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c336529f20ee2b89f6faf97c36eef7
https://doi.org/10.1007/s10565-022-09698-1
https://doi.org/10.1007/s10565-022-09698-1