Sex-Dependent Impairment of Endothelium-Dependent Relaxation in Aorta of Mice with Overexpression of Hyaluronan in Tunica Media

Autor: Karen Axelgaard Lorentzen, Raquel Hernanz, Estéfano Pinilla, Jens Randel Nyengaard, Lise Wogensen, Ulf Simonsen

Publikováno v: Lorentzen, K A, Hernanz, R, Pinilla, E, Nyengaard, J R, Wogensen, L & Simonsen, U 2023, ' Sex-Dependent Impairment of Endothelium-Dependent Relaxation in Aorta of Mice with Overexpression of Hyaluronan in Tunica Media ', International Journal of Molecular Sciences, vol. 24, no. 9 . https://doi.org/10.3390/ijms24098436
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8436

Diabetic macroangiopathy is characterized by increased extracellular matrix deposition, including excessive hyaluronan accumulation, vessel thickening and stiffness, and endothelial dysfunction in large arteries. We hypothesized that the overexpressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a3393c638058f4dd90d0ac009ea442
https://pure.au.dk/portal/da/publications/sexdependent-impairment-of-endotheliumdependent-relaxation-in-aorta-of-mice-with-overexpression-of-hyaluronan-in-tunica-media(7c2129cc-df94-4736-bcfc-173fee213736).html

In Silico Design and Selection of New Tetrahydroisoquinoline-Based CD44 Antagonist Candidates

Autor: Atilio Reyes-Romero, Angel J Ruiz-Moreno, Marco A. Velasco-Velázquez, Alexander Dömling

Publikováno v: Molecules
Molecules, 26(7):1877. MDPI AG
Molecules, Vol 26, Iss 1877, p 1877 (2021)
Volume 26
Issue 7

CD44 promotes metastasis, chemoresistance, and stemness in different types of cancer and is a target for the development of new anti-cancer therapies. All CD44 isoforms share a common N-terminal domain that binds to hyaluronic acid (HA). Herein, we u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295badc99cedf61988dddbcfdcb66311
https://pubmed.ncbi.nlm.nih.gov/33810348

Endothelial Glycocalyx as a Shield Against Diabetic Vascular Complications

Autor: Sophie Dogné, Bruno Flamion, Nathalie Caron

The endothelial glycocalyx (EG), which covers the apical surface of the endothelial cells and floats into the lumen of the vessels, is a key player in vascular integrity and cardiovascular homeostasis. The EG is composed of PGs (proteoglycans), glyco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858d9d08a242784ac40aef28fcfc4bd6
https://researchportal.unamur.be/en/publications/3a21fa11-9cb9-496c-9e73-7e0c7699b3e5

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Autor: Dominique P. Pioletti, Rares Salomir, David Tchernin, Philippe Abdel-Sayed, Mohamadreza Nassajian Moghadam

Publikováno v: Journal of the Mechanical Behavior of Biomedical Materials
Journal of the Mechanical Behavior of Biomedical Materials, Vol. 30 (2014) pp. 123-30

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc1dbcee9caec4063b531fb2e29ba80
https://doi.org/10.1016/j.jmbbm.2013.10.025

The glycocalyx is present as soon as blood flow is initiated and is required for normal vascular development

Autor: Roya Jamarani, Sarah Al-Roubaie, Espen D. Jahnsen, Elizabeth A. V. Jones, Caitlin E Henderson-Toth

Publikováno v: Developmental Biology, 369(2), 330-9. Academic Press Inc.

The glycocalyx, and the thicker endothelial surface layer (ESL), are necessary both for endothelial barrier function and for sensing mechanical forces in the adult. The goal of this study is to use a combination of imaging techniques to establish whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7ea3cb95bbecef707b32eadad71df9
https://doi.org/10.1016/j.ydbio.2012.07.009