Arginase-induced cell death pathways and metabolic changes in cancer cells are not altered by insulin.

Autor: Chew HY; Faculty of Medicine, Frazer Institute, The University of Queensland, 37 Kent Street, Brisbane, QLD, 4102, Australia., Cvetkovic G; Hepius Biotech AG, Zurich, Switzerland., Tepic S; Hepius Biotech AG, Zurich, Switzerland., Wells JW; Faculty of Medicine, Frazer Institute, The University of Queensland, 37 Kent Street, Brisbane, QLD, 4102, Australia. j.wells3@uq.edu.au.

Publikováno v: Scientific reports [Sci Rep] 2024 Feb 19; Vol. 14 (1), pp. 4112. Date of Electronic Publication: 2024 Feb 19.

Germline ERBB3 mutation in familial non-small-cell lung carcinoma: expanding ErbB's role in oncogenesis.

Autor: McInerney-Leo AM; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia., Chew HY; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia., Inglis PL; Cancer Care Services, Royal Brisbane and Women's Hospital, Herston QLD 4029, Australia., Leo PJ; Australian Translational Genomics Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia., Joseph SR; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia., Cooper CL; Department of Anatomical Pathology, Pathology Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.; University of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia., Okano S; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia., Hassall T; Centre for Children and Adolescent Brain Cancer, Oncology Department, Queensland Children's Hospital, South Brisbane, QLD 4101, Australia., Anderson LK; Cancer Care Services, Royal Brisbane and Women's Hospital, Herston QLD 4029, Australia., Bowman RV; University of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia.; Department of Thoracic Medicine, The Prince Charles Hospital, Rode Road, Chermside, QLD 4032, Australia., Gattas M; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia., Harris JE; Australian Translational Genomics Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia., Marshall MS; Australian Translational Genomics Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia., Shaw JG; University of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia.; Department of Thoracic Medicine, The Prince Charles Hospital, Rode Road, Chermside, QLD 4032, Australia., Wheeler L; Australian Translational Genomics Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia., Yang IA; University of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia.; Department of Thoracic Medicine, The Prince Charles Hospital, Rode Road, Chermside, QLD 4032, Australia., Brown MA; Australian Translational Genomics Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia.; Guy's and St Thomas' NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, SE1 9RT, London, UK., Fong KM; University of Queensland Thoracic Research Centre, Faculty of Medicine, The University of Queensland, 288 Herston Road, Herston, QLD 4006, Australia.; Department of Thoracic Medicine, The Prince Charles Hospital, Rode Road, Chermside, QLD 4032, Australia., Simpson F; The University of Queensland Diamantina Institute, The University of Queensland, Woolloongabba, QLD 4102, Australia., Duncan EL; Australian Translational Genomics Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia.; Department of Twin Research and Genetic Epidemiology, Faculty of Life Sciences and Medicine, King's College London, WC2R 2LS, UK.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2021 Nov 30; Vol. 30 (24), pp. 2393-2401.

Will Next-Generation Immunotherapy Overcome the Intrinsic Diversity and Low Immunogenicity of Sarcomas to Improve Clinical Benefit?

Autor: Chew HY; Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Chan V; Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Simpson F; Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia., Dolcetti R; Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia.; Sir Peter MacCallum Centre for Cancer Immunotherapy, University of Melbourne, Parkville, VIC 3000, Australia.

Publikováno v: Cancers [Cancers (Basel)] 2020 Nov 16; Vol. 12 (11). Date of Electronic Publication: 2020 Nov 16.

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies.

Autor: Chew HY; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., De Lima PO; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Gonzalez Cruz JL; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Banushi B; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Echejoh G; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Hu L; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Joseph SR; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Lum B; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Rae J; Cell Biology and Molecular Medicine Division, Institute for Molecular Bioscience, University of Queensland, St Lucia QLD 4072, Australia; Australia Centre for Microscopy and Microanalysis, University of Queensland, St Lucia QLD 4072, Australia., O'Donnell JS; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Merida de Long L; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Okano S; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., King B; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Barry R; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Moi D; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Mazzieri R; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Thomas R; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Souza-Fonseca-Guimaraes F; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Foote M; Princess Alexandra Hospital, Brisbane QLD 4102, Australia., McCluskey A; Centre for Chemistry, Biology and Clinical Pharmacology, The University of Newcastle, Callaghan NSW 2308, Australia., Robinson PJ; Cell Signaling Unit, Children's Medical Research Institute, The University of Sydney, Sydney NSW 2145, Australia., Frazer IH; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Saunders NA; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Parton RG; Cell Biology and Molecular Medicine Division, Institute for Molecular Bioscience, University of Queensland, St Lucia QLD 4072, Australia; Australia Centre for Microscopy and Microanalysis, University of Queensland, St Lucia QLD 4072, Australia., Dolcetti R; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Cuff K; Princess Alexandra Hospital, Brisbane QLD 4102, Australia; Faculty of Medicine, University of Queensland, Woolloongabba QLD 4102, Australia., Martin JH; Princess Alexandra Hospital, Brisbane QLD 4102, Australia; Centre for Chemistry, Biology and Clinical Pharmacology, The University of Newcastle, Callaghan NSW 2308, Australia., Panizza B; Princess Alexandra Hospital, Brisbane QLD 4102, Australia; Faculty of Medicine, University of Queensland, Woolloongabba QLD 4102, Australia., Walpole E; Princess Alexandra Hospital, Brisbane QLD 4102, Australia; Faculty of Medicine, University of Queensland, Woolloongabba QLD 4102, Australia., Wells JW; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia., Simpson F; The University of Queensland Diamantina Institute, University of Queensland, Woolloongabba QLD 4102, Australia. Electronic address: f.simpson@uq.edu.au.

Publikováno v: Cell [Cell] 2020 Mar 05; Vol. 180 (5), pp. 895-914.e27.

Methionine is a metabolic dependency of tumor-initiating cells.

Autor: Wang Z; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yip LY; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lee JHJ; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore., Wu Z; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore., Chew HY; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chong PKW; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Teo CC; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ang HY; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Peh KLE; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yuan J; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ma S; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Choo LSK; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Basri N; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Jiang X; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yu Q; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Hillmer AM; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim WT; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Lim TKH; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Takano A; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Tan EH; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Tan DSW; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Ho YS; Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim B; Merck Sharp and Dohme Translational Medicine Research Centre, Singapore, Singapore. bing.lim@merck.com., Tam WL; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. tamwl@gis.a-star.edu.sg.; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. tamwl@gis.a-star.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. tamwl@gis.a-star.edu.sg.; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. tamwl@gis.a-star.edu.sg.

Publikováno v: Nature medicine [Nat Med] 2019 May; Vol. 25 (5), pp. 825-837. Date of Electronic Publication: 2019 May 06.