Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Hwi-yeol Yun"'
Autor:
Khanh Linh Duong, Heeyoon Jung, Hyun-kyoung Lee, Young Jin Moon, Sang Ki Lee, Bo Ram Yang, Hwi-yeol Yun, Jung-woo Chae
Publikováno v:
BMC Geriatrics, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Choline alfoscerate, a cholinergic precursor with limited evidence of efficacy in dementia management, has been used for various cognitive impairments in Korea. Partly due to its insurance coverage, this agent appears to incur sig
Externí odkaz:
https://doaj.org/article/818e2d502e984089a91797ccb9fc116e
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract Niclosamide, a potent anthelmintic agent, has emerged as a candidate against COVID‐19 in recent studies. Its formulation has been investigated extensively to address challenges related to systemic exposure. In this study, niclosamide was f
Externí odkaz:
https://doaj.org/article/8d490a5b2b1041f6905779031fdb9cae
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 4, p e1012066 (2024)
Target-mediated drug disposition (TMDD) is a phenomenon characterized by a drug's high-affinity binding to a target molecule, which significantly influences its pharmacokinetic profile within an organism. The comprehensive TMDD model delineates this
Externí odkaz:
https://doaj.org/article/1de7f4eb70b643da97351ebde5c34844
Autor:
Woojin Jung, Sungwoo Goo, Taewook Hwang, Hyunjung Lee, Young-Kuk Kim, Jung-woo Chae, Hwi-yeol Yun, Sangkeun Jung
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 382 (2024)
Machine learning techniques are extensively employed in drug discovery, with a significant focus on developing QSAR models that interpret the structural information of potential drugs. In this study, the pre-trained natural language processing (NLP)
Externí odkaz:
https://doaj.org/article/23edaa2169b34c7f985a92d265051e90
Autor:
Lien Thi Ngo, Sung‐yoon Yang, Sooyoung Shin, Duc Tuan Cao, Hung Van Nguyen, Sangkeun Jung, Jae‐Young Lee, Jong‐Hwa Lee, Hwi‐yeol Yun, Jung‐woo Chae
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 11, Pp 1430-1442 (2022)
Abstract Rivaroxaban (RIV; Xarelto; Janssen Pharmaceuticals, Beerse, Belgium) is one of the direct oral anticoagulants. The drug is a strong substrate of cytochrome P450 (CYP) enzymes and efflux transporters. This study aimed to develop a physiologic
Externí odkaz:
https://doaj.org/article/e7e968ad840048c495a151c69f08bf78
Autor:
Sung-Yoon Yang, Jin-Mu Yi, Jaemoo Chun, Seongwon Park, Tham Thi Bui, Hwi-Yeol Yun, Jung-Woo Chae, Mi-Kyung Jeong
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Atezolizumab (a PD-L1 inhibitor) has shown remarkable efficacy and tolerability in various cancer types. Despite its efficacy and safety, atezolizumab monotherapy has limitations, such as acquired resistance and adverse events. Bojungikki-tang (BJIKT
Externí odkaz:
https://doaj.org/article/0bf0127b0ada43e0b01a99b360221691
Autor:
Gwanyoung Kim, Hyun-ki Moon, Taeheon Kim, So-hye Yun, Hwi-yeol Yun, Jang Hee Hong, Dae-Duk Kim
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2357 (2023)
Camostat mesylate is expected to be promising as a treatment option for COVID-19, in addition to other indications for which it is currently used. Furthermore, in vitro experiments have confirmed the potential of camostat and its metabolites to be ef
Externí odkaz:
https://doaj.org/article/3c4b1268c7834b388b8fa2752ee80e1c
Autor:
Hyo-jeong Ryu, Won-ho Kang, Taeheon Kim, Jae Kyoung Kim, Kwang-Hee Shin, Jung-woo Chae, Hwi-yeol Yun
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Pharmacokinetic (PK) modeling is a useful method for investigating drug absorption, distribution, metabolism, and excretion. The most commonly used mathematical models in PK modeling are the compartment model and physiologically based pharmacokinetic
Externí odkaz:
https://doaj.org/article/eaabab5e83e243ef87d3f43888e1383f
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 684 (2023)
Rivaroxaban (RIV) is one of the direct oral anticoagulants used to prevent and treat venous and arterial thromboembolic events. Considering the therapeutic indications, RIV is likely to be concomitantly administered with various other drugs. Among th
Externí odkaz:
https://doaj.org/article/7e9e51f5757948dd87916482918ebdc0
Autor:
Lien Ngo, Jaeseong Oh, Anhye Kim, Hyun‐moon Back, Won‐ho Kang, Jung‐woo Chae, Hwi‐yeol Yun, Howard Lee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 10, Pp 584-595 (2020)
HL2351 (hIL‐1Ra‐hyFc) is a novel recombinant protein formed by the fusion of two human interleukin‐1 receptor antagonist components into one antibody‐derived fragment crystallizable portion. Although HL2351 has a pharmacological mechanism of
Externí odkaz:
https://doaj.org/article/42fafae2b10f4a889c0303af517dd643