Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Hwei-Jen Lee"'
Autor:
Chien-Ming Lin, Yi-Xuan Ding, Shih-Ming Huang, Ying-Chuan Chen, Hwei-Jen Lee, Chih-Chien Sung, Shih-Hua Lin
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
ContextAlthough a monoallelic mutation in the calcium-sensing receptor (CASR) gene causes familial hypocalciuric hypercalcemia (FHH), the functional characterization of the identified CASR mutation linked to the clinical response to calcimimetics the
Externí odkaz:
https://doaj.org/article/d9497854737749adab87e42ed63c9c01
Autor:
Hung-Che Lin, Hao-Ai Shui, Kuo-Yang Huang, Wei-Zhi Lin, Hsin-Yi Chang, Hwei-Jen Lee, Ying-Chih Lin, Yuahn-Sieh Huang, Guan-Ru Chen, Ya-Ting Yang, Hsiu-Lin Liu, Yi-Syuan Wu, Chia-Shiang Cheng, Ching-Lung Ko, Yu-Tien Chang, Jih-Chin Lee, Chen-Shien Lin, Chih-Hung Wang, Chi-Ming Chu
Publikováno v:
Biology, Vol 11, Iss 8, p 1210 (2022)
Both the annotation and identification of genes in pathogenic parasites are still challenging. Although, as a survival factor, nitric oxide (NO) has been proven to be synthesized in Trichomonas vaginalis (TV), nitric oxide synthase (NOS) has not yet
Externí odkaz:
https://doaj.org/article/f5e24aaa0a46453a9d2aaf2b92d67795
Autor:
Min-Hua Tseng, Wen-Lang Fan, Hsuan Liu, Chia-Yu Yang, Jhao-Jhuang Ding, Hwei-Jen Lee, Shih-Ming Huang, Shih-Hua Lin, Jing-Long Huang
Publikováno v:
Frontiers in Medicine, Vol 7 (2021)
Objective: Renal thrombotic microangiopathy (TMA) is associated with complement overactivation and poor outcome in patients with lupus nephritis (LN). The role of genetic makeup of complement system in these patients remains to be elucidated.Methods:
Externí odkaz:
https://doaj.org/article/07041b3c1985432f93bfc9d9a5874361
Autor:
Ching-Ming Lin, Jay-How Yang, Hwei-Jen Lee, Yu-Pang Lin, Li-Ping Tsai, Chih-Sin Hsu, G. W. Gant Luxton, Chih-Fen Hu
Publikováno v:
Life, Vol 11, Iss 11, p 1230 (2021)
Background: Cockayne syndrome (CS) is a rare form of dwarfism that is characterized by progressive premature aging. CS is typically caused by mutations in the excision repair cross-complementing protein group 6 (ERCC6) gene that encodes the CS group
Externí odkaz:
https://doaj.org/article/2f06896b361347308d379e7f110296a8
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0145957 (2016)
δ-Crystallin is the major structural protein in avian eye lenses and is homologous to the urea cycle enzyme argininosuccinate lyase. This protein is structurally assembled as double dimers. Lys-315 is the only residue which is arranged symmetrically
Externí odkaz:
https://doaj.org/article/6f99013b4a5f47b38fed8b26b1b83e52
Autor:
Chi-Ching Hwang, Yi-Hsun Chang, Hwei-Jen Lee, Tzu-Pin Wang, Yu-Mei Su, Hsin-Wei Chen, Po-Huang Liang
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63594 (2013)
3α-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni reversibly catalyzes the oxidation of androsterone with NAD(+) to form androstanedione and NADH. Structurally the substrate-binding loop of the residues, T188-K208, is un
Externí odkaz:
https://doaj.org/article/5d21877c0bad475fb497996253eccd6d
Autor:
Jang-Foung Lin, Yung-Lin Sheih, Tsu-Chung Chang, Ni-Yuan Chang, Chiung-Wen Chang, Chia-Pei Shen, Hwei-Jen Lee
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e69733 (2013)
4-Hydroxylphenylpyruvate dioxygenase (4-HPPD) is an important enzyme for tyrosine catabolism, which catalyzes the conversion of 4-hydroxylphenylpyruvate (4-HPP) to homogentisate. In the present study, human 4-HPPD was cloned and expressed in E. coli.
Externí odkaz:
https://doaj.org/article/70e72bca49674d9d89c13fb3d4542ee2
Autor:
Tai-Lung Cha, Dah-Shyong Yu, Victor C. Lin, Sun-Yran Chang, Chung-Chih Lin, Ming-Rong Chen, Hui-Kuan Lin, Jar-Yi Ho, Cheng-Ping Yu, Hwei-Jen Lee, Shih-Ming Huang, Pei-Wen Hsiao, Guang-Huan Sun, Yu-Chi Chen, Sheng-Tang Wu, Shou-Hung Tang, Mei-Jen Chuang, Yi-Ta Tsai
Mitochondria are the powerhouses of cells. Mitochondrial C-Raf is a potential cancer therapeutic target, as it regulates mitochondrial function and is localized to the mitochondria by its N-terminal domain. However, Raf inhibitor monotherapy can indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfe30199dba74fae83e1e2de1326c4b
https://doi.org/10.1158/0008-5472.c.6506796
https://doi.org/10.1158/0008-5472.c.6506796
Autor:
Tai-Lung Cha, Dah-Shyong Yu, Victor C. Lin, Sun-Yran Chang, Chung-Chih Lin, Ming-Rong Chen, Hui-Kuan Lin, Jar-Yi Ho, Cheng-Ping Yu, Hwei-Jen Lee, Shih-Ming Huang, Pei-Wen Hsiao, Guang-Huan Sun, Yu-Chi Chen, Sheng-Tang Wu, Shou-Hung Tang, Mei-Jen Chuang, Yi-Ta Tsai
Supplementary Figures 1-10. Suppl. Fig. 1. The cell death caused by Raf inhibitors in RCC cells in vitro and in vivo. Suppl. Fig. 2.S-G combination therapy synergistically induced C-Raf-dependent cell death. Suppl. Fig. 3.S-G combination therapy indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b74add71abb009c6f8329d17903ffbd
https://doi.org/10.1158/0008-5472.22405299
https://doi.org/10.1158/0008-5472.22405299
Autor:
Hwei-Jen Lee, Yung-Lung Chang, Jen-Tzu Liu, Sheng-Peng Wu, Wei-Min Huang, Chi-Ching Hwang, Chih-Wei Huang, Kai-Ling Huang
Publikováno v:
Biochemical Journal. 478:2201-2215
4-Hydroxylphenylpyruvate dioxygenase (HPPD) catalyzes the conversion of 4-hydroxylphenylpyruvate (HPP) to homogentisate, the important step for tyrosine catabolism. Comparison of the structure of human HPPD with the substrate-bound structure of A. th