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Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α

Autor: Maimon E. Hubbi, Gregg L. Semenza, Jacob B. Wesley, Karin R. McDonald, Jin Hyen Baek, Hweejo Byun, Ye V. Liu

Publikováno v: Journal of Biological Chemistry. 282:23572-23580

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that functions as a master regulator of oxygen homeostasis. The HIF-1alpha subunit is subjected to O(2)-dependent prolyl hydroxylation leading to ubiquitination by the von Hip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b86ea120bcc7cfc60fd1b706cde1a00b
https://doi.org/10.1074/jbc.m703504200

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Akademický článek

Spermidine/Spermine-N¹-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α.

Autor: Jin Hyen Baek¹, Liu, Ye V.¹, McDonald, Karin R.¹, Wesley, Jacob B.¹, Hubbi, Maimon E.¹, Hweejo Byun¹, Semenza, Gregg L.¹ gsemenza@jhmi.edu

Publikováno v: Journal of Biological Chemistry. 8/10/2007, Vol. 282 Issue 32, p23572-23580. 9p. 9 Graphs.

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