Výsledky vyhledávání - "Hwee-Seon Park"

Akademický článek

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin

Autor: Abu Jubayer Hossain, Rokibul Islam, Jong-Bok Seo, Hwee-Seon Park, Jong-Il Kim, Vikas Kumar, Keun Woo Lee, Jae-Bong Park

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 18, p 13697 (2023)

Insulin is a crucial signalling molecule that primarily functions to reduce blood glucose levels through cellular uptake of glucose. In addition to its role in glucose homeostasis, insulin has been shown to regulate cell proliferation. Specifically,

Externí odkaz: https://doaj.org/article/681bb96ec5154b2e8415242eba897c09

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Akademický článek

RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A

Autor: Jae-Gyu Kim, Shohel Mahmud, Jung Ki Min, Yoon-Beom Lee, Hyunbin Kim, Dong-Chul Kang, Hwee-Seon Park, Jihye Seong, Jae-Bong Park

Publikováno v: Redox Biology, Vol 40, Iss , Pp 101842- (2021)

In the Wnt canonical pathway, Wnt3A has been known to stabilize β-catenin. In the non-canonical Wnt signaling pathway, Wnt is known to activate Rho GTPases. The correlation between canonical and non-canonical pathways by Wnt signaling, however, has

Externí odkaz: https://doaj.org/article/c5072cfca2804dc194eb41024555b432

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Akademický článek

Cross-Talk between Wnt Signaling and Src Tyrosine Kinase

Autor: Jung Ki Min, Hwee-Seon Park, Yoon-Beom Lee, Jae-Gyu Kim, Jong-Il Kim, Jae-Bong Park

Publikováno v: Biomedicines, Vol 10, Iss 5, p 1112 (2022)

Src, a non-receptor tyrosine kinase, was first discovered as a prototype oncogene and has been shown to critical for cancer progression for a variety of tissues. Src activity is regulated by a number of post-translational modifications in response to

Externí odkaz: https://doaj.org/article/045ed86afbb24d82a2e37b0c54e045c3

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Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-κB

Autor: Kyoung-Chan Choi, Yong-Sun Kim, Hwee-Seon Park, Chang-Won Hong, Eun-Kyoung Choi, Jae-Gyu Kim, Jae-Bong Park

Publikováno v: Free radical biologymedicine. 112

Dysregulation of reactive oxygen species (ROS) levels is implicated in the pathogenesis of several diseases, including cancer. However, the molecular mechanisms for ROS in tumorigenesis have not been well established. In this study, hydrogen peroxide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ab7d1a65200f9fc603dd348da070a3
https://pubmed.ncbi.nlm.nih.gov/28712859

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