Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Hwee-Cheng Tan"'
Autor:
Darren ZL Mok, Danny JH Tng, Jia Xin Yee, Valerie SY Chew, Christine YL Tham, Justin SG Ooi, Hwee Cheng Tan, Summer L Zhang, Lowell Z Lin, Wy Ching Ng, Lavanya Lakshmi Jeeva, Ramya Murugayee, Kelvin K-K Goh, Tze-Peng Lim, Liang Cui, Yin Bun Cheung, Eugenia Z Ong, Kuan Rong Chan, Eng Eong Ooi, Jenny G Low
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1310-1323 (2024)
Abstract Vaccination has successfully controlled several infectious diseases although better vaccines remain desirable. Host response to vaccination studies have identified correlates of vaccine immunogenicity that could be useful to guide developmen
Externí odkaz:
https://doaj.org/article/90c7121c4d0546eb8018f9ef0e765fd0
Autor:
Wy Ching Ng, Lowell Lin, Tanamas Siriphanitchakorn, Margaret Ke Xin Jiang, Hwee Cheng Tan, Eng Eong Ooi
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/44379f98bd22434598f314d7b317d6e9
Autor:
Jenny G. Low, Ruklanthi de Alwis, Shiwei Chen, Shirin Kalimuddin, Yan Shan Leong, Tania Ken Lin Mah, Natalene Yuen, Hwee Cheng Tan, Summer L. Zhang, Jean X. Y. Sim, Yvonne F. Z. Chan, Ayesa Syenina, Jia Xin Yee, Eugenia Z. Ong, Rose Sekulovich, Brian B. Sullivan, Kelly Lindert, Sean M. Sullivan, Pad Chivukula, Steven G. Hughes, Eng Eong Ooi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phase
Externí odkaz:
https://doaj.org/article/8f3f3b68e6d74f248a8f293e7fa6c66a
Autor:
Wy Ching Ng, Swee Sen Kwek, Bo Sun, Meisam Yousefi, Eugenia Z. Ong, Hwee Cheng Tan, Andreas S. Puschnik, Kuan Rong Chan, Yaw Shin Ooi, Eng Eong Ooi
Publikováno v:
Open Biology, Vol 12, Iss 12 (2022)
The four dengue viruses (DENVs) have evolved multiple mechanisms to ensure its survival. Among these mechanisms is the ability to regulate its replication rate, which may contribute to avoiding premature immune activation that limit infection dissemi
Externí odkaz:
https://doaj.org/article/6458694551b142398b420ec817c446de
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101297- (2022)
Summary: Aberrant cellular bioenergetics has detrimental consequences in host cells. For instance, pathogenic Zika virus strains can suppress mitochondria respiration and glycolytic functions, disrupting cellular bioenergetics that leads to apoptosis
Externí odkaz:
https://doaj.org/article/23b60498dae54c3da1ab9f474195b662
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)
Abstract Dengue poses a significant burden of individual health, health systems and the economy in dengue endemic regions. As such, dengue vaccine development has been an active area of research. Previous studies selected attenuated vaccine candidate
Externí odkaz:
https://doaj.org/article/e74404e1387b4601ad89e5f5720fa7a9
Autor:
Clement Yau, John Z.H. Low, Esther S. Gan, Swee Sen Kwek, Liang Cui, Hwee Cheng Tan, Darren Z.L. Mok, Candice Y.Y. Chan, October M. Sessions, Satoru Watanabe, Subhash G. Vasudevan, Yie Hou Lee, Kuan Rong Chan, Eng Eong Ooi
Publikováno v:
Cell Reports, Vol 37, Iss 11, Pp 110118- (2021)
Summary: Zika virus (ZIKV) is an Aedes-mosquito-borne flavivirus that causes debilitating congenital and developmental disorders. Improved understanding of ZIKV pathogenesis could assist efforts to fill the therapeutic and vaccine gap. We use several
Externí odkaz:
https://doaj.org/article/c9c9770ca3924e2aab660c35a83c87ce
Autor:
Eugenia Z Ong, Shirin Kalimuddin, Wen Chong Chia, Sarah H Ooi, Clara WT Koh, Hwee Cheng Tan, Summer L Zhang, Jenny G Low, Eng Eong Ooi, Kuan Rong Chan
Publikováno v:
EBioMedicine, Vol 65, Iss , Pp 103262- (2021)
Background: The coronavirus disease-19 (COVID-19) pandemic has cost lives and economic hardships globally. Various studies have found a number of different factors, such as hyperinflammation and exhausted/suppressed T cell responses to the etiologica
Externí odkaz:
https://doaj.org/article/d6f6c1cac5c141919137bbb6f1d39c7c
Autor:
Clement Yau, Esther Shuyi Gan, Swee Sen Kwek, Hwee Cheng Tan, Eugenia Z. Ong, Noor Zayanah Hamis, Laura Rivino, Kuan Rong Chan, Satoru Watanabe, Subhash G. Vasudevan, Eng Eong Ooi
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103028- (2020)
Background: The emergence of Zika virus (ZIKV) as an important cause of congenital and childhood developmental disorders presents another challenge to global health. Efforts to develop a Zika vaccine have begun although vaccine development against fl
Externí odkaz:
https://doaj.org/article/1aaa19728d0f4e10a0c4451030eb9e76
Autor:
Swee Sen Kwek, Satoru Watanabe, Kuan Rong Chan, Eugenia Z. Ong, Hwee Cheng Tan, Wy Ching Ng, Mien T. X. Nguyen, Esther S. Gan, Summer L. Zhang, Kitti W. K. Chan, Jun Hao Tan, October M. Sessions, Menchie Manuel, Julien Pompon, Camillus Chua, Sharifah Hazirah, Karl Tryggvason, Subhash G. Vasudevan, Eng Eong Ooi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse an
Externí odkaz:
https://doaj.org/article/2200a4c3d0464f52b6e961470788a10a