Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hwang Hsing Chen"'
Autor:
Abdelmoula Namil, Mark R. Hellberg, Andrew Rusinko, Bryon S. Severns, Jennifer Ward, Colene Drace, Iok-Hou Pang, Shenouda Yacoub, Keith D. Combrink, Curtis R. Kelly, Byron Li, Marsha A. McLaughlin, Raj Patil, N.A. Sharif, Hwang Hsing Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:1875-1879
A series of 2,3,6-pyrazine Rho Kinase inhibitors were optimized for in vivo activity for topical ocular dosing. Modifications of the 2-(piperazin-1-yl)pyrazine derivatives produced compounds with improved solubility and physicochemical properties. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d182bc1267668fdba6283e228caac75f
https://doi.org/10.1016/j.bmcl.2014.03.017
https://doi.org/10.1016/j.bmcl.2014.03.017
Autor:
Jesse A. May, Najam A. Sharif, Hwang-Hsing Chen, John C. Liao, Curtis R. Kelly, Richard A. Glennon, Richard Young, Jun-Xu Li, Kenner C. Rice, Charles P. France
Publikováno v:
Pharmacology Biochemistry and Behavior. 91:307-314
AL-38022A is a novel synthetic serotonergic (5-HT) ligand that exhibited high affinity for each of the 5-HT2 receptor subtypes (Ki ≤ 2.2 nM), but a significantly lower (>100-fold less) affinity for other 5-HT receptors. In addition, AL-38022A displ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6141a94380080c4f073dc5f24b951f7
https://doi.org/10.1016/j.pbb.2008.07.015
https://doi.org/10.1016/j.pbb.2008.07.015
Autor:
Mark R. Hellberg, Bryon S. Severns, William F. Holt, Richard Young, Richard A. Glennon, Thomas R. Dean, Najam A. Sharif, Hwang-Hsing Chen, Curtis R. Kelly, Marsha A. McLaughlin, Jesse A. May
Publikováno v:
Journal of medicinal chemistry. 58(22)
Recently, it has been reported that 5-HT2 receptor agonists effectively reduce intraocular pressure (IOP) in a nonhuman primate model of glaucoma. Although 1-[(2S)-2-aminopropyl]indazol-6-ol (AL-34662) was shown to have good efficacy in this nonhuman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efded27acf90f8c38ea878165340de3
https://pubmed.ncbi.nlm.nih.gov/26551970
https://pubmed.ncbi.nlm.nih.gov/26551970
Autor:
Marsha A. McLaughlin, Andrew Rusinko, Vincent M. Lynch, Hwang-Hsing Chen, Jesse A. May, Najam A. Sharif
Publikováno v:
Journal of Medicinal Chemistry. 46:4188-4195
Serotonin 5-HT2 receptor agonists have recently been shown to be effective in lowering intraocular pressure in nonhuman primates and represent a potential new class of antiglaucoma agents. As part of an effort to identify new selective agonists at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9285e939bc004b5842090164c93655
https://doi.org/10.1021/jm030205t
https://doi.org/10.1021/jm030205t
Autor:
Sharon Gross, William S. Sly, Hwang-Hsing Chen, Marsha A. McLaughlin, Jesse A. May, Thomas R. Dean, John B. Liao
Publikováno v:
Bioorganic & Medicinal Chemistry. 8:957-975
Novel non-chiral 2H-thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides were synthesized for evaluation as potential candidates for the treatment of glaucoma. All of the compounds prepared were potent high affinity inhibitors of human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177b596e158b58341704f907315d92f3
https://doi.org/10.1016/s0968-0896(00)00026-2
https://doi.org/10.1016/s0968-0896(00)00026-2
Publikováno v:
Journal of Heterocyclic Chemistry. 36:249-256
A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides provided the first examples of thiophene[2,3-b]thiophene-2-sulfonarnide 6,6-dioxides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26f9a645fb74b069fd06dbfe07319e4c
https://doi.org/10.1002/jhet.5570360138
https://doi.org/10.1002/jhet.5570360138
Publikováno v:
ChemInform. 30
A series of the title compounds were prepared for evaluation as inhibitors of carbonic anhydrase II. Oxidation of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides provided the first examples of thiophene[2,3-b]thiophene-2-sulfonarnide 6,6-dioxides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1567985c7b5450559c3781ba94a998e2
https://doi.org/10.1002/chin.199931135
https://doi.org/10.1002/chin.199931135
Autor:
Samantha G. Zeitlin, L. Crenshaw, Jesse A. May, Thomas R. Dean, P. A. Boriack-Sjodin, P. Delgado, Hwang-Hsing Chen, A. Dantanarayana, David W. Christianson, S. Gross
Publikováno v:
Protein science : a publication of the Protein Society. 7(12)
X-ray crystal structures of carbonic anhydrase II (CAII) complexed with sulfonamide inhibitors illuminate the structural determinants of high affinity binding in the nanomolar regime. The primary binding interaction is the coordination of a primary s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4ae36434512a935653cb3789053bb7
https://pubmed.ncbi.nlm.nih.gov/9865942
https://pubmed.ncbi.nlm.nih.gov/9865942
Autor:
Jesse A. May, NajamA. Sharif, MarshaA. McLaughlin, Hwang-Hsing Chen, Bryon S. Severns, Curtis R. Kelly, William F. Holt, Richard Young, Richard A. Glennon, Mark R. Hellberg, Thomas R. Dean
Publikováno v:
Journal of Medicinal Chemistry; Nov2015, Vol. 58 Issue 22, p8818-8833, 16p
Autor:
Hwang-Hsing Chen
Publikováno v:
The Journal of the Acoustical Society of America. 119:3509
An improved fish finding device and method for detecting and distinguishing marine life from a sonar reflected marker that generates artificial echoes comprises steps of 1. transmitting of sonar waves 2. receiving of sonar echoes 3. distinguishing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a142bd52bd27ccec4f83af20a0af41ea
https://doi.org/10.1121/1.2212549
https://doi.org/10.1121/1.2212549