Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hwai Wen Chang"'
Autor:
Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTEpithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that plays several roles in cancer biology. EpCAM is an attractive therapeutic target because of its expression in most solid tumors. However, targeting EpCAM has been
Externí odkaz:
https://doaj.org/article/7fc31e7a3b674b338e4ac1b2672d0edf
Autor:
Haizhen Liu, Hwai Wen Chang, Jay M. Short, Lawrence Steinman, Charles Xing, Gerhard Frey, William J. Boyle
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance On-target, off-tumor toxicity of anti-CTLA4 checkpoint inhibitors leads to severe adverse events, restricting therapeutic efficacy. We engineered anti-CTLA4 antibodies and generated a new class of antibodies referred to as conditionally
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12384-12389
Y box-binding protein 1 (YB-1) is a multifunctional protein that can act as a regulator of transcription and of translation. In chicken embryo fibroblasts transformed by the oncoproteins P3k (phosphatidylinositol 3-kinase) or Akt, YB-1 is transcripti
Autor:
David J. Brayden, Wendy Tynan, Claire F. Evans, Janet Dickerson, Lisa Higgins, Melinda Scharf, Daragh Byrne, Hwai-Wen Chang, Jason Mendy, David Lo, Daniel J. O'mahony
Publikováno v:
Cellular Immunology. 224:8-16
Mammalian Peyer's Patches possess specialized epithelium, the follicle associated epithelium (FAE), and specialized cells called M cells which mediate transcytosis of antigens to underlying lymphoid tissue. To identify FAE specific genes, we used TOG
Autor:
Masahiro Aoki, Peter K. Vogt, Hwai Wen Chang, Martin Himly, Osvaldo Batista, Christian Schetter
Publikováno v:
Journal of Biological Chemistry. 275:6267-6275
The retroviral oncogene p3k (v-p3k) of avian sarcoma virus 16 (ASV16) codes for the catalytic subunit of phosphoinositide (PI) 3-kinase, p110alpha. The v-P3k protein is oncogenic in vivo and in vitro; its cellular counterpart, c-P3k, lacks oncogenici
Publikováno v:
Journal of Virology. 69:6605-6608
Vaccinia virus with the E3L gene deleted was able to replicate in RK-13 but not HeLa cells. This host range phenotype could be complemented by an E3L gene expressed transiently from a plasmid. Analysis of mutants of E3L indicates that the ability to
Autor:
Hwai-Wen Chang, Bertram L. Jacobs
Publikováno v:
Virology. 194:537-547
The E3L gene of vaccinia virus encodes the double-stranded (ds) RNA binding proteins p20 and p25 that exhibit inhibitory activity for the IFN-induced, P 1 /eIF-2α protein kinase. A region in the E3L encoded proteins (residues 156-180) shares a high
Publikováno v:
Journal of Virology. 67:1688-1692
Vaccinia virus has evolved multiple mechanisms to counteract the interferon-induced antiviral host cell response. Recently, two vaccinia virus gene products were shown to interfere with the activity of the double-stranded RNA-dependent protein kinase
Publikováno v:
Proceedings of the National Academy of Sciences. 89:4825-4829
A vaccinia virus-encoded double-stranded RNA-binding protein, p25, has been previously implicated in inhibition of the interferon-induced, double-stranded RNA-activated protein kinase. In this study, we have identified the vaccinia viral gene (WR str
Autor:
Julie A. Ellison, Ting-Kai Li, Tiebing Liang, Lawrence Lumeng, Tatiana Foroud, Hwai Wen Chang, Lixiang Liu, Lucinda G. Carr, John P. Spence, Wendy N. Strother
Total gene expression analysis (TOGA) was used to identify genes that are differentially expressed in brain regions between the alcohol-naïve, inbred alcohol-preferring (iP), and -nonpreferring (iNP) rats. α-Synuclein, expressed at >2-fold higher l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69878351748e8cb34ac1b4c7c6dd69b9
https://europepmc.org/articles/PMC153617/
https://europepmc.org/articles/PMC153617/