Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Hwa-Chain Robert Wang"'
Autor:
Rupesh Agarwal, Pawat Pattarawat, Michael R. Duff, Hwa-Chain Robert Wang, Jerome Baudry, Jeremy C. Smith
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 867 (2024)
Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goal. Herein,
Externí odkaz:
https://doaj.org/article/8c72edc793fc47ea81c5a0326e30330a
Autor:
Yan-Hong Yong, Ping Wang, Ru-Min Jia, Ravi Gooneratne, Hwa-Chain Robert Wang, Ming Liao, Xiang-Hong Ju
Publikováno v:
International Journal of Hyperthermia, Vol 36, Iss 1, Pp 150-158 (2019)
Hyperthermia in pigs induces suppressor of cytokine signaling (SOCS) 3 and SOCS4 expression in intestinal gut and causes disruption of inflammation cytokine production. These changes may affect the development of inflammatory bowel disease in heat-st
Externí odkaz:
https://doaj.org/article/36834aa2fdc54127a33a30305c58e506
Autor:
Wen Meng, Shi-Chong Han, Cui-Cui Li, Hui-Jun Dong, Jian-Yu Chang, Hwa-Chain Robert Wang, Xiao-Jia Wang
Publikováno v:
Viruses, Vol 10, Iss 4, p 208 (2018)
NOP53 is a tumor suppressor protein located in the nucleolus and is translocated to the cytoplasm during infection by vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1), as shown in our previous study. Cytoplasmic NOP53 interact
Externí odkaz:
https://doaj.org/article/c7608297848948748ee46804fad82c13
Publikováno v:
Frontiers in Microbiology, Vol 6 (2015)
Development of highly effective, broad-spectrum antiviral agents is the major objective shared by the fields of virology and pharmaceutics. Antiviral drug development has focused on targeting viral entry and replication, as well as modulating cellula
Externí odkaz:
https://doaj.org/article/54bed2fe333842f3b2d9a5a8760bb2e9
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e108698 (2014)
Breast cancer is the most common type of cancer affecting women in North America and Europe. More than 85% of breast cancers are sporadic and attributable to long-term exposure to small quantities of multiple carcinogens. To understand how multiple c
Externí odkaz:
https://doaj.org/article/738af430f695459282b7ac3d7bb787a1
Publikováno v:
Cancer Chemother Pharmacol
PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive, lethal, heterogeneous type of breast cancer (BC). TNBC tends to have a lower response rate to chemotherapy and a lower fiveyear survival rate than other types of BC due to recurrence and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05edcc7ac3a3d0156ba88a16e1011e4a
https://doi.org/10.1007/s00280-021-04298-y
https://doi.org/10.1007/s00280-021-04298-y
Autor:
Rupesh Agarwal, Pawat Pattarawat, Michael R. Duff, Hwa-Chain Robert Wang, Jerome Baudry, Jeremy C. Smith
Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. Here, we use molecular modeling approaches to identify and targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b00127d9b4c7cd16108081d50a770ce
https://doi.org/10.1101/2022.05.31.494169
https://doi.org/10.1101/2022.05.31.494169
Autor:
Chia-Lung Tsai, Pawat Pattarawat, Shelby Wallace, Tzu-Hao Wang, Robert L. Donnell, Jinquan Wang, Yanchun Hu, Tian Hong, Hwa-Chain Robert Wang
Publikováno v:
British Journal of Cancer
Background Human urothelial carcinoma (UC) has a high tendency to recur and progress to life-threatening advanced diseases. Advanced therapeutic regimens are needed to control UC development and recurrence. Methods We pursued in vitro and in vivo stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1fc12407136b125179d81253d31750f
https://doi.org/10.1038/s41416-020-0877-8
https://doi.org/10.1038/s41416-020-0877-8
Publikováno v:
Drug Discovery Today
Highlights • Drug repositioning is a cost- and time-efficient approach for new indications. • Targeting host machineries, used by viruses, could develop broad-spectrum antivirals. • Repurposing existing drugs could efficiently identify antivira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33593b3f47acf1a0b85a2b3e8ed475d0
https://doi.org/10.1016/j.drudis.2019.01.018
https://doi.org/10.1016/j.drudis.2019.01.018
Autor:
Yun-Ru Liu, Chi-Cheng Huang, Li-Ching Chen, Tzu-chun Cheng, Hui Wen Chang, Wendy W. Hwang-Verslues, Hang‐Lung Chang, Chih-Hsiung Wu, Abdul-Fattah Salah Fararjeh, Yuan Soon Ho, Shih Hsin Tu, Hwa-Chain Robert Wang
Publikováno v:
Environmental Toxicology. 34:73-82
Breast cancer (BC) is the most common cancer affecting women worldwide and has been associated with active tobacco smoking. Low levels of nicotine (Nic) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), have been detected in cases of second-h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a528d85be3da268b841970f5368ec77
https://doi.org/10.1002/tox.22659
https://doi.org/10.1002/tox.22659