Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hwa Young Yun"'
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102128- (2023)
Summary: We present a protocol to generate high-quality fluorescently labeled DNA substrates that can be used for biochemical assays, including DNA-binding and nuclease activity assays. We describe polyacrylamide-gel-electrophoresis-based purificatio
Externí odkaz:
https://doaj.org/article/99b049ee760c4e17be12e15f95282c2b
Autor:
Stanley Zhou, James R. Hawley, Fraser Soares, Giacomo Grillo, Mona Teng, Seyed Ali Madani Tonekaboni, Junjie Tony Hua, Ken J. Kron, Parisa Mazrooei, Musaddeque Ahmed, Christopher Arlidge, Hwa Young Yun, Julie Livingstone, Vincent Huang, Takafumi N. Yamaguchi, Shadrielle M. G. Espiritu, Yanyun Zhu, Tesa M. Severson, Alex Murison, Sarina Cameron, Wilbert Zwart, Theodorus van der Kwast, Trevor J. Pugh, Michael Fraser, Paul C. Boutros, Robert G. Bristow, Housheng Hansen He, Mathieu Lupien
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
FOXA1 pioneer transcription factor is recurrently mutated in primary and metastatic prostate tumors. Here, authors identify a set of six cis-regulatory elements in the FOXA1 regulatory plexus harboring somatic SNVs in primary prostate tumors and char
Externí odkaz:
https://doaj.org/article/ced842dd69954226b920c3219e59c1a5
Autor:
Robert Siddaway, Laura Canty, Sanja Pajovic, Scott Milos, Etienne Coyaud, Stefanie-Grace Sbergio, Arun Kumaran Vadivel Anguraj, Evan Lubanszky, Hwa Young Yun, Alessia Portante, Sheyenne Carette, Cunjie Zhang, Michael F. Moran, Brian Raught, Eric I. Campos, Cynthia Hawkins
Publikováno v:
Acta Neuropathologica. 144:1027-1048
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative PRC2 inhibition, while H3G34R mutations
Publikováno v:
Innovation studies. 16:1-32
Autor:
Brandon J. Payliss, Ying Wah E. Tse, Sean E. Reichheld, Alexander Lemak, Hwa Young Yun, Scott Houliston, Ayushi Patel, Cheryl H. Arrowsmith, Simon Sharpe, Haley D.M. Wyatt
Publikováno v:
Cell reports. 41(4)
The DNA repair scaffold SLX4 has multifaceted roles in genome stability, many of which depend on structure-selective endonucleases. SLX4 coordinates the cell cycle-regulated assembly of SLX1, MUS81-EME1, and XPF-ERCC1 into a tri-nuclease complex call
Autor:
Robert Siddaway, Scott Milos, Étienne Coyaud, Hwa Young Yun, Shahir M. Morcos, Sanja Pajovic, Eric I. Campos, Brian Raught, Cynthia Hawkins
Publikováno v:
Molecular & Cellular Proteomics. 21:100411
Chromatin structure, transcription, DNA replication, and repair are regulated via locus-specific incorporation of histone variants and posttranslational modifications that guide effector chromatin-binding proteins. Here we report unbiased, quantitati
Autor:
Tesa M. Severson, Shadrielle Melijah G. Espiritu, Stanley Zhou, James R. Hawley, Alex Murison, Sarina Cameron, Fraser Soares, Giacomo Grillo, Paul C. Boutros, Housheng Hansen He, Hwa Young Yun, Mathieu Lupien, Wilbert Zwart, Mona Teng, Takafumi N. Yamaguchi, Christopher Arlidge, Trevor J. Pugh, Julie Livingstone, Yanyun Zhu, Junjie Tony Hua, Parisa Mazrooei, Seyed Ali Madani Tonekaboni, Musaddeque Ahmed, Theodorus van der Kwast, Ken Kron, Robert G. Bristow, Vincent Huang, Michael Fraser
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, 11(1):441. Nature Publishing Group
Zhou, S, Hawley, J R, Soares, F, Grillo, G, Teng, M, Madani Tonekaboni, S A, Hua, J T, Kron, K J, Mazrooei, P, Ahmed, M, Arlidge, C, Yun, H Y, Livingstone, J, Huang, V, Yamaguchi, T N, Espiritu, S M G, Zhu, Y, Severson, T M, Murison, A, Cameron, S, Zwart, W, van der Kwast, T, Pugh, T J, Fraser, M, Boutros, P C, Bristow, R G, He, H H & Lupien, M 2020, ' Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer ', Nature Communications, vol. 11, no. 1, pp. 441 . https://doi.org/10.1038/s41467-020-14318-9
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, 11(1):441. Nature Publishing Group
Zhou, S, Hawley, J R, Soares, F, Grillo, G, Teng, M, Madani Tonekaboni, S A, Hua, J T, Kron, K J, Mazrooei, P, Ahmed, M, Arlidge, C, Yun, H Y, Livingstone, J, Huang, V, Yamaguchi, T N, Espiritu, S M G, Zhu, Y, Severson, T M, Murison, A, Cameron, S, Zwart, W, van der Kwast, T, Pugh, T J, Fraser, M, Boutros, P C, Bristow, R G, He, H H & Lupien, M 2020, ' Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer ', Nature Communications, vol. 11, no. 1, pp. 441 . https://doi.org/10.1038/s41467-020-14318-9
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Prostate cancer is the second most commonly diagnosed malignancy among men worldwide. Recurrently mutated in primary and metastatic prostate tumors, FOXA1 encodes a pioneer transcription factor involved in disease onset and progression through both a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b626c7d898073e745f03d5f6019068
https://escholarship.org/uc/item/13k437wt
https://escholarship.org/uc/item/13k437wt
Autor:
Yu Cao, David T. Rodgers, Juanjuan Du, Insha Ahmad, Eric N. Hampton, Jennifer S. Y. Ma, Magdalena Mazagova, Sei-hyun Choi, Hwa Young Yun, Han Xiao, Pengyu Yang, Xiaozhou Luo, Reyna K. V. Lim, Holly M. Pugh, Feng Wang, Stephanie A. Kazane, Timothy M. Wright, Chan Hyuk Kim, Peter G. Schultz, Travis S. Young
Publikováno v:
Angewandte Chemie. 128:7646-7650
Autor:
Ma, Jennifer S. Y., Ji Young Kim, Kazane, Stephanie A., Sei-hyun Choi, Hwa Young Yun, Min Soo Kim, Rodgers, David T., Pugh, Holly M., Singer, Oded, Sun, Sophie B., Fonslow, Bryan R., Kochenderfer, James N., Wright, Timothy M., Schultz, Peter G., Young, Travis S., Chan Hyuk Kim, Yu Cao
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 1/26/2016, Vol. 113 Issue 4, pE450-E458, 9p