Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hwa C, Lee"'
Publikováno v:
Pfl�gers Archiv - European Journal of Physiology. 449:403-412
Cardiac sodium channels (Nav1.5) comprise a pore-forming α-subunit and auxiliary β-subunits that modulate channel function. In the heart, β1 is expressed throughout the atria and ventricles, whilst β3 is present only in the ventricles and Purkinj
Publikováno v:
Neuron. 40:527-536
In voltage-activated potassium (Kv) channels, basic residues in S4 enable the voltage-sensing domain to move in response to membrane depolarization and thereby trigger the activation gate to open. In the X-ray structure of the KvAP channel, the S4 he
Publikováno v:
The Journal of General Physiology
Voltage-activated ion channels open and close in response to changes in membrane voltage, a property that is fundamental to the roles of these channels in electrical signaling. Protein toxins from venomous organisms commonly target the S1–S4 voltag
Publikováno v:
Pflugers Archiv : European journal of physiology. 449(4)
Cardiac sodium channels (Na(v)1.5) comprise a pore-forming alpha-subunit and auxiliary beta-subunits that modulate channel function. In the heart, beta1 is expressed throughout the atria and ventricles, whilst beta3 is present only in the ventricles
Abnormal Na channel gating in murine cardiac myocytes deficient in myotonic dystrophy protein kinase
Autor:
Qingcai Wang, Dilawaar J. Mistry, J. Paul Mounsey, J. Randall Moorman, Sita Reddy, Manoj K. Patel, Hwa C. Lee
Publikováno v:
Physiological genomics. 12(2)
DMPK is a serine/threonine kinase implicated in the human disease myotonic muscular dystrophy (DM). Skeletal muscle Na channels exhibit late reopenings in Dmpk-deficient mice and peak current density is reduced, implicating DMPK in regulation of memb